Drugs for risk factors

Drugs for common risk factors of diseases

Outcome trait

 

P-value threshold: 1e-5
   

 

 

Summary

This view attempts to find potential drugs for a disease outcome via SNPs that influence causal risk factors for that outcome. For a given disease we find potential causal risk factors. For each of those risk factors we take robustly associated genetic variants and map those to gene (this is currently just a physical distance mapping). Drugs that target the products of those genes are then identified using data from Open Targets.

Data sources

  • Gene to drug mappings are taken from Open Targets using their API
  • Causal estimates are from MR-EvE (Hemani et al, Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome, bioRxiv 10.1101/173682)
  • SNP-trait assocaitions are from the IEU GWAS database

How to use

Enter your disease outcome in the Disease trait text box, use the slider to select a p-value threshold for the strength of MR causal evidence, then click Search.

Top results are presented in the Network plot tab, with full results searchable in the Table tab. The Query tab provides information to enable you to download full results using the API.

Examples

 Displays 150 / 641 paths

 

assoc_trait.id assoc_trait.trait drug.label gene.name mr.estimate mr.method mr.moescore mr.p mr.se mr.selection snp.name trait.id trait.trait
UKB-a:491 Medication for cholesterol blood pressure or diabetes: Insulin SULFONAMIDES TCF7L2 -11.933316 FE IVW 1.00 0.000000e+00 0.048230 DF rs7903146 12 Crohn's disease
UKB-a:491 Medication for cholesterol blood pressure or diabetes: Insulin METYROSINE TH -11.933316 FE IVW 1.00 0.000000e+00 0.048230 DF rs3842729 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks TEZAMPANEL GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks PF-04958242 GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks SELURAMPANEL GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks MIBAMPATOR GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks FARAMPATOR GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks ZONAMPANEL GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks MK-8777 GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks PERAMPANEL GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks TOPIRAMATE GRIA1 2.350225 FE IVW 1.00 0.000000e+00 0.051466 DF rs6896622 12 Crohn's disease
761 Corrected insulin response TASIMELTEON MTNR1B -0.986368 FE IVW 1.00 0.000000e+00 0.010035 DF rs10830963 13 Crohn's disease
761 Corrected insulin response AGOMELATINE MTNR1B -0.986368 FE IVW 1.00 0.000000e+00 0.010035 DF rs10830963 13 Crohn's disease
761 Corrected insulin response RAMELTEON MTNR1B -0.986368 FE IVW 1.00 0.000000e+00 0.010035 DF rs10830963 13 Crohn's disease
73 Waist-to-hip ratio AFLIBERCEPT VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
73 Waist-to-hip ratio BEVACIZUMAB VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
73 Waist-to-hip ratio RANIBIZUMAB VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
73 Waist-to-hip ratio PEGAPTANIB SODIUM VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
73 Waist-to-hip ratio CONBERCEPT VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
73 Waist-to-hip ratio MUPARFOSTAT VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
73 Waist-to-hip ratio BROLUCIZUMAB VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
73 Waist-to-hip ratio VANUCIZUMAB VEGFA 1.246439 FE IVW 1.00 0.000000e+00 0.007221 DF rs998584 14 Crohn's disease
449 N-acetylglycine METFORMIN NDUFV1 -0.352648 FE IVW 1.00 3.820660e-249 0.010461 DF rs7948073 30 Crohn's disease
449 N-acetylglycine ME-344 NDUFV1 -0.352648 FE IVW 1.00 3.820660e-249 0.010461 DF rs7948073 30 Crohn's disease
449 N-acetylglycine CARGLUMIC ACID CPS1 -0.352648 FE IVW 1.00 3.820660e-249 0.010461 DF rs715 30 Crohn's disease
449 N-acetylglycine VALPROIC ACID CPS1 -0.352648 FE IVW 1.00 3.820660e-249 0.010461 DF rs715 30 Crohn's disease
294 Inflammatory bowel disease TOSEDOSTAT ERAP2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs1363907 30 Crohn's disease
294 Inflammatory bowel disease SCH-708980 IL10 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs3024493 30 Crohn's disease
294 Inflammatory bowel disease ALDESLEUKIN IL2RA 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs12722515 30 Crohn's disease
294 Inflammatory bowel disease BASILIXIMAB IL2RA 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs12722515 30 Crohn's disease
294 Inflammatory bowel disease DACLIZUMAB IL2RA 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs12722515 30 Crohn's disease
294 Inflammatory bowel disease DENILEUKIN DIFTITOX IL2RA 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs12722515 30 Crohn's disease
294 Inflammatory bowel disease LMB-2 IL2RA 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs12722515 30 Crohn's disease
294 Inflammatory bowel disease RUXOLITINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease TOFACITINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease BARICITINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease PEFICITINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease MOMELOTINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease FEDRATINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease LESTAURTINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease PACRITINIB JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease AT-9283 JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease AZD-1480 JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease TG-02 JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease XL-019 JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease BMS-911543 JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease NS-018 JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease AC-430 JAK2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs10758669 30 Crohn's disease
294 Inflammatory bowel disease BENSERAZIDE DDC 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs11768997 30 Crohn's disease
294 Inflammatory bowel disease CARBIDOPA DDC 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs11768997 30 Crohn's disease
294 Inflammatory bowel disease BAMINERCEPT LTB 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA) INHIBITORS TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease ADALIMUMAB TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease INFLIXIMAB TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease CERTOLIZUMAB PEGOL TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease ETANERCEPT TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease GOLIMUMAB TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease ONERCEPT TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease OZORALIZUMAB TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease PEGSUNERCEPT TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease PLACULUMAB TNF 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs769177 30 Crohn's disease
294 Inflammatory bowel disease MIFAMURTIDE NOD2 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs7194886 30 Crohn's disease
294 Inflammatory bowel disease DIPYRIDAMOLE PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease THEOPHYLLINE PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease PENTOXIFYLLINE PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease FLAVOXATE PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease APREMILAST PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease ROFLUMILAST PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease CRISABOROLE PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease AMLEXANOX PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
294 Inflammatory bowel disease DYPHYLLINE PDE4A 1.206639 Simple median 0.84 4.341211e-140 0.047889 HF rs35164067 30 Crohn's disease
789 Urate ROSUVASTATIN ABCG2 0.256376 FE IVW 1.00 8.989348e-123 0.010880 DF rs2231142 14 Crohn's disease
UKB-a:53 Worry too long after embarrassment RISPERIDONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ORDOPIDINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment SB-773812 DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PRIDOPIDINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment SARIZOTAN DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment LUMATEPERONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment BIFEPRUNOX DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PARDOPRUNOX DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment CLEBOPRIDE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment TRIFLUOPERAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment LOXAPINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ACETOPHENAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment AMINEPTINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment TRIMIPRAMINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment QUETIAPINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment OLANZAPINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment RISPERIDONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ARIPIPRAZOLE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PALIPERIDONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment CLOZAPINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment CARIPRAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PRAMIPEXOLE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PALIPERIDONE PALMITATE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ASENAPINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment AMISULPRIDE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment HALOPERIDOL DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment BROMOCRIPTINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment LURASIDONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ROPINIROLE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment SERTINDOLE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment BREXPIPRAZOLE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ROTIGOTINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment BENPERIDOL DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment METOCLOPRAMIDE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment HALOPERIDOL DECANOATE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment CABERGOLINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PERPHENAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ZIPRASIDONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ERGOLOID DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment DROPERIDOL DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment AMOXAPINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PROCHLORPERAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment THIOTHIXENE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ILOPERIDONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment TRIFLUPROMAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment FLUPHENAZINE DECANOATE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment APOMORPHINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment ARIPIPRAZOLE LAUROXIL DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PROMAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment MOLINDONE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PIMOZIDE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment CHLORPROMAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment MESORIDAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment FLUPHENAZINE ENANTHATE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment THIORIDAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment PERGOLIDE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment LEVOMEPROMAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment FLUPHENAZINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment BROMPERIDOL DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment MINAPRINE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:53 Worry too long after embarrassment CHLORPROTHIXENE DRD2 -1.562517 FE IVW 1.00 3.995000e-116 0.068213 DF rs12364051 13 Crohn's disease
UKB-a:533 Diagnoses - main ICD10: I21 Acute myocardial infarction HMG COA REDUCTASE INHIBITORS LPA 12.810748 FE IVW 1.00 7.919459e-101 0.600968 DF rs55730499 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine CAPTOPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine RAMIPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine FOSINOPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine BENAZEPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine LISINOPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine QUINAPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine TRANDOLAPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine PERINDOPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine CAPTOPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine ENALAPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine CILAZAPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine MOEXIPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine SPIRAPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine ENALAPRILAT ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
720 X-14205--alpha-glutamyltyrosine CAPTOPRIL ACE -0.284527 FE IVW 1.00 4.461696e-67 0.016444 DF rs4351 30 Crohn's disease
464 Serine CARGLUMIC ACID CPS1 3.502695 FE IVW 1.00 1.981582e-63 0.208341 DF rs715 11 Crohn's disease
464 Serine VALPROIC ACID CPS1 3.502695 FE IVW 1.00 1.981582e-63 0.208341 DF rs715 11 Crohn's disease
294 Inflammatory bowel disease TOSEDOSTAT ERAP2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs1363907 12 Crohn's disease
294 Inflammatory bowel disease SCH-708980 IL10 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs3024493 12 Crohn's disease
294 Inflammatory bowel disease ALDESLEUKIN IL2RA 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs12722515 12 Crohn's disease
294 Inflammatory bowel disease BASILIXIMAB IL2RA 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs12722515 12 Crohn's disease
294 Inflammatory bowel disease DACLIZUMAB IL2RA 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs12722515 12 Crohn's disease
294 Inflammatory bowel disease DENILEUKIN DIFTITOX IL2RA 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs12722515 12 Crohn's disease
294 Inflammatory bowel disease LMB-2 IL2RA 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs12722515 12 Crohn's disease
294 Inflammatory bowel disease RUXOLITINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease TOFACITINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease BARICITINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease PEFICITINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease MOMELOTINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease FEDRATINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease LESTAURTINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease PACRITINIB JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease AT-9283 JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease AZD-1480 JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease TG-02 JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease XL-019 JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease BMS-911543 JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease NS-018 JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease AC-430 JAK2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs10758669 12 Crohn's disease
294 Inflammatory bowel disease BENSERAZIDE DDC 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs11768997 12 Crohn's disease
294 Inflammatory bowel disease CARBIDOPA DDC 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs11768997 12 Crohn's disease
294 Inflammatory bowel disease BAMINERCEPT LTB 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA) INHIBITORS TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease ADALIMUMAB TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease INFLIXIMAB TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease CERTOLIZUMAB PEGOL TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease ETANERCEPT TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease GOLIMUMAB TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease ONERCEPT TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease OZORALIZUMAB TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease PEGSUNERCEPT TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease PLACULUMAB TNF 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs769177 12 Crohn's disease
294 Inflammatory bowel disease MIFAMURTIDE NOD2 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs7194886 12 Crohn's disease
294 Inflammatory bowel disease DIPYRIDAMOLE PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease THEOPHYLLINE PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease PENTOXIFYLLINE PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease FLAVOXATE PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease APREMILAST PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease ROFLUMILAST PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease CRISABOROLE PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease AMLEXANOX PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
294 Inflammatory bowel disease DYPHYLLINE PDE4A 1.070054 Simple mean 0.93 1.247185e-48 0.020981 HF rs35164067 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks TRIAMCINOLONE CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks FLUTICASONE/SALMETEROL CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks FLUTICASONE PROPIONATE CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks BUDESONIDE CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks ONO-2333MS CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks SSR125543 CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks PEXACERFONT CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks VERUCERFONT CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
UKB-a:244 Frequency of tenseness / restlessness in last 2 weeks EMICERFONT CRHR1 2.129245 FE IVW 1.00 1.169712e-41 0.157473 DF rs62055701 12 Crohn's disease
970 Ulcerative colitis TOFACITINIB TYK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs12720356 12 Crohn's disease
970 Ulcerative colitis PEFICITINIB TYK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs12720356 12 Crohn's disease
970 Ulcerative colitis CERDULATINIB TYK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs12720356 12 Crohn's disease
970 Ulcerative colitis EFALIZUMAB ITGAL 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs11150589 12 Crohn's disease
970 Ulcerative colitis LIFITEGRAST ITGAL 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs11150589 12 Crohn's disease
970 Ulcerative colitis RUXOLITINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis TOFACITINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis BARICITINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis PEFICITINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis MOMELOTINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis FEDRATINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis LESTAURTINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis PACRITINIB JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis AT-9283 JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis AZD-1480 JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis TG-02 JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis XL-019 JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis BMS-911543 JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis NS-018 JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis AC-430 JAK2 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs10758669 12 Crohn's disease
970 Ulcerative colitis LAPATINIB HLA-DQA1 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs9271858 12 Crohn's disease
970 Ulcerative colitis SCH-708980 IL10 0.455612 Weighted median 0.82 8.740840e-35 0.037033 Tophits rs3024493 12 Crohn's disease
UKB-a:75 Non-cancer illness code self-reported: type 2 diabetes SULFONAMIDES TCF7L2 -11.324948 FE IVW 1.00 3.231825e-30 0.991468 DF rs35198068 30 Crohn's disease
UKB-a:260 Tobacco smoking: Ex-smoker LORVOTUZUMAB MERTANSINE NCAM1 -1.066785 FE IVW 1.00 1.554602e-29 0.094530 DF rs4479020 30 Crohn's disease
UKB-a:260 Tobacco smoking: Ex-smoker BB-10901 NCAM1 -1.066785 FE IVW 1.00 1.554602e-29 0.094530 DF rs4479020 30 Crohn's disease
UKB-a:15 Daytime dozing / sleeping (narcolepsy) SB-649868 HCRTR2 -1.981010 FE IVW 1.00 2.553645e-28 0.179500 DF rs3122170 11 Crohn's disease
UKB-a:15 Daytime dozing / sleeping (narcolepsy) LEMBOREXANT HCRTR2 -1.981010 FE IVW 1.00 2.553645e-28 0.179500 DF rs3122170 11 Crohn's disease
UKB-a:15 Daytime dozing / sleeping (narcolepsy) SUVOREXANT HCRTR2 -1.981010 FE IVW 1.00 2.553645e-28 0.179500 DF rs3122170 11 Crohn's disease
936 Total fatty acids ATORVASTATIN APOE 1.085379 FE IVW 1.00 6.264220e-27 0.101014 DF rs429358 13 Crohn's disease
316 Uridine TIPIRACIL TYMP 3.694440 FE IVW 1.00 2.316365e-24 0.362738 DF rs131794 30 Crohn's disease
UKB-a:217 Illnesses of siblings: Heart disease HMG COA REDUCTASE INHIBITORS LPA 4.691339 FE IVW 1.00 7.657991e-21 0.500983 DF rs118039278 30 Crohn's disease
31 Inflammatory bowel disease APOLIZUMAB HLA-DRB5 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs113473719 30 Crohn's disease
31 Inflammatory bowel disease LAPATINIB HLA-DQA1 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs9272514 30 Crohn's disease
31 Inflammatory bowel disease LAPATINIB HLA-DQA1 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs28383456 30 Crohn's disease
31 Inflammatory bowel disease TOSEDOSTAT ERAP2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs6873866 30 Crohn's disease
31 Inflammatory bowel disease SCH-708980 IL10 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs3024493 30 Crohn's disease
31 Inflammatory bowel disease DIPYRIDAMOLE PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease THEOPHYLLINE PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease PENTOXIFYLLINE PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease FLAVOXATE PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease APREMILAST PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease ROFLUMILAST PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease CRISABOROLE PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease AMLEXANOX PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease DYPHYLLINE PDE4A 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs142770866 30 Crohn's disease
31 Inflammatory bowel disease MIFAMURTIDE NOD2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs2076756 30 Crohn's disease
31 Inflammatory bowel disease RUXOLITINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease TOFACITINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease BARICITINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease PEFICITINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease MOMELOTINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease FEDRATINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease LESTAURTINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease PACRITINIB JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease AT-9283 JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease AZD-1480 JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease TG-02 JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease XL-019 JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease BMS-911543 JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease NS-018 JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
31 Inflammatory bowel disease AC-430 JAK2 0.978414 Simple mean 0.78 8.559936e-20 0.065044 Tophits rs1887428 30 Crohn's disease
751 Palmitoyl sphingomyelin ATORVASTATIN APOE -0.606870 FE IVW 1.00 3.729787e-19 0.067847 DF rs445925 30 Crohn's disease
UKB-a:51 Worrier / anxious feelings RESEQUINIL GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings PF-06372865 GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ADIPIPLON GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings GANAXOLONE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings TRIAZOLAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings INDIPLON GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings FLURAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings GABOXADOL GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings PRAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings CLOTIAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings FLUMAZENIL GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings OXAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ISOFLURANE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings CLORAZEPIC ACID GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings HALAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ETOMIDATE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings CHLORDIAZEPOXIDE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings METHOXYFLURANE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings CLONAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings DESFLURANE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings DIAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings CLOBAZAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ACAMPROSATE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings SEVOFLURANE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings TEMAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings MEPROBAMATE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ALPRAZOLAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings PROPOFOL GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings TOPIRAMATE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings LORAZEPAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ESTAZOLAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ESZOPICLONE GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings MIDAZOLAM GABRA1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs28422082 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings TRIAMCINOLONE CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings FLUTICASONE/SALMETEROL CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings FLUTICASONE PROPIONATE CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings BUDESONIDE CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings ONO-2333MS CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings SSR125543 CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings PEXACERFONT CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings VERUCERFONT CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:51 Worrier / anxious feelings EMICERFONT CRHR1 -4.383550 FE IVW 0.71 1.943453e-16 0.532921 DF rs77804065 13 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine SEVOFLURANE KCNK3 1.008516 FE IVW 1.00 1.157230e-15 0.125924 DF rs1275922 14 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine ISOFLURANE KCNK3 1.008516 FE IVW 1.00 1.157230e-15 0.125924 DF rs1275922 14 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine DESFLURANE KCNK3 1.008516 FE IVW 1.00 1.157230e-15 0.125924 DF rs1275922 14 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine DOXAPRAM KCNK3 1.008516 FE IVW 1.00 1.157230e-15 0.125924 DF rs1275922 14 Crohn's disease
31 Inflammatory bowel disease APOLIZUMAB HLA-DRB5 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs113473719 12 Crohn's disease
31 Inflammatory bowel disease LAPATINIB HLA-DQA1 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs9272514 12 Crohn's disease
31 Inflammatory bowel disease LAPATINIB HLA-DQA1 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs28383456 12 Crohn's disease
31 Inflammatory bowel disease TOSEDOSTAT ERAP2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs6873866 12 Crohn's disease
31 Inflammatory bowel disease SCH-708980 IL10 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs3024493 12 Crohn's disease
31 Inflammatory bowel disease DIPYRIDAMOLE PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease THEOPHYLLINE PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease PENTOXIFYLLINE PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease FLAVOXATE PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease APREMILAST PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease ROFLUMILAST PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease CRISABOROLE PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease AMLEXANOX PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease DYPHYLLINE PDE4A 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs142770866 12 Crohn's disease
31 Inflammatory bowel disease MIFAMURTIDE NOD2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs2076756 12 Crohn's disease
31 Inflammatory bowel disease RUXOLITINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease TOFACITINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease BARICITINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease PEFICITINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease MOMELOTINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease FEDRATINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease LESTAURTINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease PACRITINIB JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease AT-9283 JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease AZD-1480 JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease TG-02 JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease XL-019 JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease BMS-911543 JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease NS-018 JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
31 Inflammatory bowel disease AC-430 JAK2 0.784720 Weighted mode 0.68 1.915479e-14 0.062883 DF rs1887428 12 Crohn's disease
970 Ulcerative colitis TOFACITINIB TYK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs12720356 30 Crohn's disease
970 Ulcerative colitis PEFICITINIB TYK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs12720356 30 Crohn's disease
970 Ulcerative colitis CERDULATINIB TYK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs12720356 30 Crohn's disease
970 Ulcerative colitis EFALIZUMAB ITGAL 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs11150589 30 Crohn's disease
970 Ulcerative colitis LIFITEGRAST ITGAL 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs11150589 30 Crohn's disease
970 Ulcerative colitis RUXOLITINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis TOFACITINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis BARICITINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis PEFICITINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis MOMELOTINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis FEDRATINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis LESTAURTINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis PACRITINIB JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis AT-9283 JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis AZD-1480 JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis TG-02 JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis XL-019 JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis BMS-911543 JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis NS-018 JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis AC-430 JAK2 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs10758669 30 Crohn's disease
970 Ulcerative colitis LAPATINIB HLA-DQA1 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs9271858 30 Crohn's disease
970 Ulcerative colitis SCH-708980 IL10 0.470742 RE IVW 0.78 3.816446e-14 0.041735 DF + HF rs3024493 30 Crohn's disease
636 X-12644 CERIVASTATIN SLCO1B1 3.779326 FE IVW 1.00 5.703690e-14 0.502924 DF rs7969341 13 Crohn's disease
636 X-12644 SIMVASTATIN SLCO1B1 3.779326 FE IVW 1.00 5.703690e-14 0.502924 DF rs7969341 13 Crohn's disease
636 X-12644 PRAVASTATIN SLCO1B1 3.779326 FE IVW 1.00 5.703690e-14 0.502924 DF rs7969341 13 Crohn's disease
636 X-12644 ROSUVASTATIN SLCO1B1 3.779326 FE IVW 1.00 5.703690e-14 0.502924 DF rs7969341 13 Crohn's disease
636 X-12644 METHOTREXATE SLCO1B1 3.779326 FE IVW 1.00 5.703690e-14 0.502924 DF rs7969341 13 Crohn's disease
856 Omega-6 fatty acids ATORVASTATIN APOE 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs7412 13 Crohn's disease
856 Omega-6 fatty acids HMG COA REDUCTASE INHIBITORS CETP 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs821840 13 Crohn's disease
856 Omega-6 fatty acids DALCETRAPIB CETP 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs821840 13 Crohn's disease
856 Omega-6 fatty acids EVACETRAPIB CETP 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs821840 13 Crohn's disease
856 Omega-6 fatty acids ANACETRAPIB CETP 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs821840 13 Crohn's disease
856 Omega-6 fatty acids EVOLOCUMAB PCSK9 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs11591147 13 Crohn's disease
856 Omega-6 fatty acids ALIROCUMAB PCSK9 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs11591147 13 Crohn's disease
856 Omega-6 fatty acids BOCOCIZUMAB PCSK9 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs11591147 13 Crohn's disease
856 Omega-6 fatty acids RALPANCIZUMAB PCSK9 1.253788 FE IVW 1.00 1.925961e-12 0.178101 DF rs11591147 13 Crohn's disease
UKB-a:209 Illnesses of mother: Heart disease CARGLUMIC ACID CPS1 3.915965 FE IVW 1.00 8.400647e-12 0.573218 DF rs1047891 30 Crohn's disease
UKB-a:209 Illnesses of mother: Heart disease VALPROIC ACID CPS1 3.915965 FE IVW 1.00 8.400647e-12 0.573218 DF rs1047891 30 Crohn's disease
UKB-a:209 Illnesses of mother: Heart disease HMG COA REDUCTASE INHIBITORS LPA 3.915965 FE IVW 1.00 8.400647e-12 0.573218 DF rs74617384 30 Crohn's disease
921 Total lipids in small HDL ATORVASTATIN APOE 0.482919 FE IVW 1.00 1.575082e-11 0.071641 DF rs7412 11 Crohn's disease
UKB-a:104 Non-cancer illness code self-reported: ulcerative colitis NEVIRAPINE HLA-DRB1 113.238161 Simple median 0.62 1.595164e-11 16.803489 HF rs149717632 30 Crohn's disease
UKB-a:104 Non-cancer illness code self-reported: ulcerative colitis APOLIZUMAB HLA-DRB1 113.238161 Simple median 0.62 1.595164e-11 16.803489 HF rs149717632 30 Crohn's disease
32 Ulcerative colitis ALVERINE HNF4A 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs6017342 30 Crohn's disease
32 Ulcerative colitis RUXOLITINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis TOFACITINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis BARICITINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis PEFICITINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis MOMELOTINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis FEDRATINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis LESTAURTINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis PACRITINIB JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis AT-9283 JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis AZD-1480 JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis TG-02 JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis XL-019 JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis BMS-911543 JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis NS-018 JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis AC-430 JAK2 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs1887428 30 Crohn's disease
32 Ulcerative colitis LAPATINIB HLA-DQA1 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs9272514 30 Crohn's disease
32 Ulcerative colitis LAPATINIB HLA-DQA1 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs28383456 30 Crohn's disease
32 Ulcerative colitis APOLIZUMAB HLA-DRB5 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs113473719 30 Crohn's disease
32 Ulcerative colitis SCH-708980 IL10 0.407597 Simple median 0.69 3.841925e-11 0.061663 Tophits rs3024493 30 Crohn's disease
UKB-a:104 Non-cancer illness code self-reported: ulcerative colitis NEVIRAPINE HLA-DRB1 79.056885 Penalised median 0.64 4.558647e-11 12.006184 HF rs149717632 12 Crohn's disease
UKB-a:104 Non-cancer illness code self-reported: ulcerative colitis APOLIZUMAB HLA-DRB1 79.056885 Penalised median 0.64 4.558647e-11 12.006184 HF rs149717632 12 Crohn's disease
761 Corrected insulin response TASIMELTEON MTNR1B -1.138864 FE IVW 1.00 1.655584e-10 0.178218 DF rs10830963 14 Crohn's disease
761 Corrected insulin response AGOMELATINE MTNR1B -1.138864 FE IVW 1.00 1.655584e-10 0.178218 DF rs10830963 14 Crohn's disease
761 Corrected insulin response RAMELTEON MTNR1B -1.138864 FE IVW 1.00 1.655584e-10 0.178218 DF rs10830963 14 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones OXYCODONE ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones ONDANSETRON ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones TRAMADOL ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones SIMVASTATIN ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones SUNITINIB ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones FENTANYL ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones DIGOXIN ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones NEVIRAPINE ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones MORPHINE ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones METHOTREXATE ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones METHADONE ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones ANTIDEPRESSANTS ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones TARIQUIDAR ABCB1 -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs3842 11 Crohn's disease
UKB-a:71 Non-cancer illness code self-reported: cholelithiasis/gall stones ALVERINE HNF4A -15.056040 FE IVW 1.00 6.679606e-10 2.438819 DF rs1800961 11 Crohn's disease
UKB-a:320 Age at last live birth NARNATUMAB MST1R 0.823832 FE IVW 1.00 9.232069e-10 0.134566 DF rs2230590 30 Crohn's disease
UKB-a:320 Age at last live birth MK-8033 MST1R 0.823832 FE IVW 1.00 9.232069e-10 0.134566 DF rs2230590 30 Crohn's disease
UKB-a:320 Age at last live birth MGCD-265 MST1R 0.823832 FE IVW 1.00 9.232069e-10 0.134566 DF rs2230590 30 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine SEVOFLURANE KCNK3 4.063789 FE IVW 1.00 3.068063e-09 0.685534 DF rs1275922 11 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine ISOFLURANE KCNK3 4.063789 FE IVW 1.00 3.068063e-09 0.685534 DF rs1275922 11 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine DESFLURANE KCNK3 4.063789 FE IVW 1.00 3.068063e-09 0.685534 DF rs1275922 11 Crohn's disease
UKB-a:150 Treatment/medication code: amlodipine DOXAPRAM KCNK3 4.063789 FE IVW 1.00 3.068063e-09 0.685534 DF rs1275922 11 Crohn's disease
464 Serine CARGLUMIC ACID CPS1 1.398675 FE IVW 1.00 4.899323e-09 0.239067 DF rs715 12 Crohn's disease
464 Serine VALPROIC ACID CPS1 1.398675 FE IVW 1.00 4.899323e-09 0.239067 DF rs715 12 Crohn's disease
970 Ulcerative colitis TOFACITINIB TYK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs12720356 14 Crohn's disease
970 Ulcerative colitis PEFICITINIB TYK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs12720356 14 Crohn's disease
970 Ulcerative colitis CERDULATINIB TYK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs12720356 14 Crohn's disease
970 Ulcerative colitis EFALIZUMAB ITGAL 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs11150589 14 Crohn's disease
970 Ulcerative colitis LIFITEGRAST ITGAL 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs11150589 14 Crohn's disease
970 Ulcerative colitis RUXOLITINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis TOFACITINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis BARICITINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis PEFICITINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis MOMELOTINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis FEDRATINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis LESTAURTINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis PACRITINIB JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis AT-9283 JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis AZD-1480 JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis TG-02 JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis XL-019 JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis BMS-911543 JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis NS-018 JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis AC-430 JAK2 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs10758669 14 Crohn's disease
970 Ulcerative colitis LAPATINIB HLA-DQA1 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs9271858 14 Crohn's disease
970 Ulcerative colitis SCH-708980 IL10 0.744842 Simple mean 0.78 1.219097e-08 0.117459 HF rs3024493 14 Crohn's disease
847 Average number of methylene groups per double bond ATORVASTATIN APOE 0.317976 FE IVW 1.00 1.997525e-08 0.056658 DF rs7412 30 Crohn's disease
996 Eczema TNX-650 IL13 -0.305454 FE IVW 1.00 2.725717e-08 0.054956 DF rs12188917 12 Crohn's disease
996 Eczema ANRUKINZUMAB IL13 -0.305454 FE IVW 1.00 2.725717e-08 0.054956 DF rs12188917 12 Crohn's disease
996 Eczema QAX-576 IL13 -0.305454 FE IVW 1.00 2.725717e-08 0.054956 DF rs12188917 12 Crohn's disease
996 Eczema TRALOKINUMAB IL13 -0.305454 FE IVW 1.00 2.725717e-08 0.054956 DF rs12188917 12 Crohn's disease
996 Eczema LEBRIKIZUMAB IL13 -0.305454 FE IVW 1.00 2.725717e-08 0.054956 DF rs12188917 12 Crohn's disease
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina ATORVASTATIN LDLR 12.511893 FE IVW 1.00 2.999584e-08 2.257869 DF rs8106503 11 Crohn's disease
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina ATORVASTATIN APOE 12.511893 FE IVW 1.00 2.999584e-08 2.257869 DF rs7412 11 Crohn's disease
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina COLLAGENASE CLOSTRIDIUM HISTOLYTICUM COL4A1 12.511893 FE IVW 1.00 2.999584e-08 2.257869 DF rs11617955 11 Crohn's disease
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina OCRIPLASMIN COL4A1 12.511893 FE IVW 1.00 2.999584e-08 2.257869 DF rs11617955 11 Crohn's disease
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina HMG COA REDUCTASE INHIBITORS LPA 12.511893 FE IVW 1.00 2.999584e-08 2.257869 DF rs55730499 11 Crohn's disease
921 Total lipids in small HDL ATORVASTATIN APOE 0.641706 FE IVW 1.00 3.390191e-08 0.116251 DF rs7412 12 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease HMG COA REDUCTASE INHIBITORS LPA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs55730499 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease AMBRISENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease BOSENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease MACITENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease DARUSENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease ATRASENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease SPARSENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease CLAZOSENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease SITAXENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease ZIBOTENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease TEZOSENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease AVOSENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease NEBENTAN EDNRA 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs77249653 11 Crohn's disease
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease ATORVASTATIN APOE 9.991136 FE IVW 1.00 4.123350e-08 1.821377 DF rs429358 11 Crohn's disease
905 Cholesterol esters in medium LDL ATORVASTATIN LDLR -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs137992968 11 Crohn's disease
905 Cholesterol esters in medium LDL EVOLOCUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs553741 11 Crohn's disease
905 Cholesterol esters in medium LDL ALIROCUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs553741 11 Crohn's disease
905 Cholesterol esters in medium LDL BOCOCIZUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs553741 11 Crohn's disease
905 Cholesterol esters in medium LDL RALPANCIZUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs553741 11 Crohn's disease
905 Cholesterol esters in medium LDL EVOLOCUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs11591147 11 Crohn's disease
905 Cholesterol esters in medium LDL ALIROCUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs11591147 11 Crohn's disease
905 Cholesterol esters in medium LDL BOCOCIZUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs11591147 11 Crohn's disease
905 Cholesterol esters in medium LDL RALPANCIZUMAB PCSK9 -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs11591147 11 Crohn's disease
905 Cholesterol esters in medium LDL ATORVASTATIN APOE -1.107056 FE IVW 1.00 4.177510e-08 0.201900 DF rs7412 11 Crohn's disease
54 Hip circumference BERUBICIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference MM-302 TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference BECATECARIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference ALDOXORUBICIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference VALRUBICIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference VOSAROXIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference AMRUBICIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference ETOPOSIDE PHOSPHATE TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference AMSACRINE TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference TENIPOSIDE TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference MITOXANTRONE TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference DOXORUBICIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference ETOPOSIDE TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference DAUNORUBICIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference IDARUBICIN TOP2A 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs13695 30 Crohn's disease
54 Hip circumference FRESOLIMUMAB TGFB2 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs12048049 30 Crohn's disease
54 Hip circumference PALBOCICLIB CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference RIBOCICLIB CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference ABEMACICLIB CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference RONICICLIB CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference ALVOCIDIB CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference UCN-01 CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference AT-7519 CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference PHA-793887 CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
54 Hip circumference AZD-5438 CDK6 0.554817 FE IVW 0.72 4.486672e-08 0.101419 Tophits rs42235 30 Crohn's disease
856 Omega-6 fatty acids ATORVASTATIN APOE 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs7412 12 Crohn's disease
856 Omega-6 fatty acids HMG COA REDUCTASE INHIBITORS CETP 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs821840 12 Crohn's disease
856 Omega-6 fatty acids DALCETRAPIB CETP 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs821840 12 Crohn's disease
856 Omega-6 fatty acids EVACETRAPIB CETP 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs821840 12 Crohn's disease
856 Omega-6 fatty acids ANACETRAPIB CETP 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs821840 12 Crohn's disease
856 Omega-6 fatty acids EVOLOCUMAB PCSK9 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs11591147 12 Crohn's disease
856 Omega-6 fatty acids ALIROCUMAB PCSK9 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs11591147 12 Crohn's disease
856 Omega-6 fatty acids BOCOCIZUMAB PCSK9 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs11591147 12 Crohn's disease
856 Omega-6 fatty acids RALPANCIZUMAB PCSK9 0.362285 FE IVW 1.00 8.607940e-08 0.067668 DF rs11591147 12 Crohn's disease
883 Total lipids in large LDL EVOLOCUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs553741 11 Crohn's disease
883 Total lipids in large LDL ALIROCUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs553741 11 Crohn's disease
883 Total lipids in large LDL BOCOCIZUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs553741 11 Crohn's disease
883 Total lipids in large LDL RALPANCIZUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs553741 11 Crohn's disease
883 Total lipids in large LDL EVOLOCUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs11591147 11 Crohn's disease
883 Total lipids in large LDL ALIROCUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs11591147 11 Crohn's disease
883 Total lipids in large LDL BOCOCIZUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs11591147 11 Crohn's disease
883 Total lipids in large LDL RALPANCIZUMAB PCSK9 -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs11591147 11 Crohn's disease
883 Total lipids in large LDL ATORVASTATIN LDLR -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs137992968 11 Crohn's disease
883 Total lipids in large LDL ATORVASTATIN APOE -1.083614 FE IVW 1.00 1.631497e-07 0.206912 DF rs7412 11 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin SULFONAMIDES TCF7L2 -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs35198068 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin ATORVASTATIN LDLR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs17248727 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin ATORVASTATIN LDLR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs2569550 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin HMG COA REDUCTASE INHIBITORS LPA -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs74617384 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin HMG COA REDUCTASE INHIBITORS HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin SIMVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin ATORVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin ROSUVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin PRAVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin FLUVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin PITAVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin CERIVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin LOVASTATIN HMGCR -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs12916 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin EVOLOCUMAB PCSK9 -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs11591147 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin ALIROCUMAB PCSK9 -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs11591147 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin BOCOCIZUMAB PCSK9 -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs11591147 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin RALPANCIZUMAB PCSK9 -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs11591147 14 Crohn's disease
UKB-a:121 Treatment/medication code: simvastatin ATORVASTATIN APOE -4.986651 FE IVW 0.73 1.728833e-07 0.954135 DF rs7412 14 Crohn's disease
881 Cholesterol esters in large VLDL ATORVASTATIN APOE -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs7412 11 Crohn's disease
881 Cholesterol esters in large VLDL ATORVASTATIN LDLR -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs137992968 11 Crohn's disease
881 Cholesterol esters in large VLDL EVOLOCUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs11591147 11 Crohn's disease
881 Cholesterol esters in large VLDL ALIROCUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs11591147 11 Crohn's disease
881 Cholesterol esters in large VLDL BOCOCIZUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs11591147 11 Crohn's disease
881 Cholesterol esters in large VLDL RALPANCIZUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs11591147 11 Crohn's disease
881 Cholesterol esters in large VLDL EVOLOCUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs553741 11 Crohn's disease
881 Cholesterol esters in large VLDL ALIROCUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs553741 11 Crohn's disease
881 Cholesterol esters in large VLDL BOCOCIZUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs553741 11 Crohn's disease
881 Cholesterol esters in large VLDL RALPANCIZUMAB PCSK9 -1.063455 FE IVW 1.00 2.948495e-07 0.207434 DF rs553741 11 Crohn's disease
936 Total fatty acids ATORVASTATIN APOE 0.404710 FE IVW 1.00 3.045102e-07 0.079035 DF rs429358 12 Crohn's disease
880 Total cholesterol in large LDL EVOLOCUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs553741 11 Crohn's disease
880 Total cholesterol in large LDL ALIROCUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs553741 11 Crohn's disease
880 Total cholesterol in large LDL BOCOCIZUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs553741 11 Crohn's disease
880 Total cholesterol in large LDL RALPANCIZUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs553741 11 Crohn's disease
880 Total cholesterol in large LDL EVOLOCUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs11591147 11 Crohn's disease
880 Total cholesterol in large LDL ALIROCUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs11591147 11 Crohn's disease
880 Total cholesterol in large LDL BOCOCIZUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs11591147 11 Crohn's disease
880 Total cholesterol in large LDL RALPANCIZUMAB PCSK9 -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs11591147 11 Crohn's disease
880 Total cholesterol in large LDL ATORVASTATIN LDLR -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs137992968 11 Crohn's disease
880 Total cholesterol in large LDL ATORVASTATIN APOE -1.107751 FE IVW 1.00 3.293166e-07 0.216957 DF rs7412 11 Crohn's disease
958 Concentration of chylomicrons and largest VLDL particles HMG COA REDUCTASE INHIBITORS LPA 0.409773 FE IVW 1.00 1.224109e-06 0.084460 DF rs74617384 12 Crohn's disease
958 Concentration of chylomicrons and largest VLDL particles ATORVASTATIN APOE 0.409773 FE IVW 1.00 1.224109e-06 0.084460 DF rs72654473 12 Crohn's disease
907 Concentration of medium LDL particles ATORVASTATIN APOE -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs7412 11 Crohn's disease
907 Concentration of medium LDL particles ATORVASTATIN LDLR -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs137992968 11 Crohn's disease
907 Concentration of medium LDL particles EVOLOCUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs553741 11 Crohn's disease
907 Concentration of medium LDL particles ALIROCUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs553741 11 Crohn's disease
907 Concentration of medium LDL particles BOCOCIZUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs553741 11 Crohn's disease
907 Concentration of medium LDL particles RALPANCIZUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs553741 11 Crohn's disease
907 Concentration of medium LDL particles EVOLOCUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs11591147 11 Crohn's disease
907 Concentration of medium LDL particles ALIROCUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs11591147 11 Crohn's disease
907 Concentration of medium LDL particles BOCOCIZUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs11591147 11 Crohn's disease
907 Concentration of medium LDL particles RALPANCIZUMAB PCSK9 -0.914639 FE IVW 1.00 1.774484e-06 0.191445 DF rs11591147 11 Crohn's disease
952 Triglycerides in very large VLDL HMG COA REDUCTASE INHIBITORS LPA 0.393989 FE IVW 1.00 2.217533e-06 0.083251 DF rs10455872 12 Crohn's disease
952 Triglycerides in very large VLDL ATORVASTATIN APOE 0.393989 FE IVW 1.00 2.217533e-06 0.083251 DF rs438811 12 Crohn's disease
UKB-a:101 Non-cancer illness code self-reported: malabsorption/coeliac disease APOLIZUMAB HLA-DRB5 -13.479804 Penalised median 0.65 2.518301e-06 2.863996 Tophits rs117108573 12 Crohn's disease
UKB-a:101 Non-cancer illness code self-reported: malabsorption/coeliac disease ASPIRIN HLA-DPB1 -13.479804 Penalised median 0.65 2.518301e-06 2.863996 Tophits rs1431403 12 Crohn's disease
885 Phospholipids in large LDL ATORVASTATIN LDLR -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs79915079 11 Crohn's disease
885 Phospholipids in large LDL ATORVASTATIN APOE -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs7412 11 Crohn's disease
885 Phospholipids in large LDL EVOLOCUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs553741 11 Crohn's disease
885 Phospholipids in large LDL ALIROCUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs553741 11 Crohn's disease
885 Phospholipids in large LDL BOCOCIZUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs553741 11 Crohn's disease
885 Phospholipids in large LDL RALPANCIZUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs553741 11 Crohn's disease
885 Phospholipids in large LDL EVOLOCUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs11591147 11 Crohn's disease
885 Phospholipids in large LDL ALIROCUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs11591147 11 Crohn's disease
885 Phospholipids in large LDL BOCOCIZUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs11591147 11 Crohn's disease
885 Phospholipids in large LDL RALPANCIZUMAB PCSK9 -0.947317 FE IVW 1.00 2.653784e-06 0.201731 DF rs11591147 11 Crohn's disease
UKB-a:320 Age at last live birth NARNATUMAB MST1R 1.805402 FE IVW 1.00 3.007847e-06 0.386572 DF rs2230590 12 Crohn's disease
UKB-a:320 Age at last live birth MK-8033 MST1R 1.805402 FE IVW 1.00 3.007847e-06 0.386572 DF rs2230590 12 Crohn's disease
UKB-a:320 Age at last live birth MGCD-265 MST1R 1.805402 FE IVW 1.00 3.007847e-06 0.386572 DF rs2230590 12 Crohn's disease
31 Inflammatory bowel disease APOLIZUMAB HLA-DRB5 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs113473719 11 Crohn's disease
31 Inflammatory bowel disease LAPATINIB HLA-DQA1 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs9272514 11 Crohn's disease
31 Inflammatory bowel disease LAPATINIB HLA-DQA1 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs28383456 11 Crohn's disease
31 Inflammatory bowel disease TOSEDOSTAT ERAP2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs6873866 11 Crohn's disease
31 Inflammatory bowel disease SCH-708980 IL10 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs3024493 11 Crohn's disease
31 Inflammatory bowel disease DIPYRIDAMOLE PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease THEOPHYLLINE PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease PENTOXIFYLLINE PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease FLAVOXATE PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease APREMILAST PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease ROFLUMILAST PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease CRISABOROLE PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease AMLEXANOX PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease DYPHYLLINE PDE4A 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs142770866 11 Crohn's disease
31 Inflammatory bowel disease MIFAMURTIDE NOD2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs2076756 11 Crohn's disease
31 Inflammatory bowel disease RUXOLITINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease TOFACITINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease BARICITINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease PEFICITINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease MOMELOTINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease FEDRATINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease LESTAURTINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease PACRITINIB JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease AT-9283 JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease AZD-1480 JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease TG-02 JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease XL-019 JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease BMS-911543 JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease NS-018 JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
31 Inflammatory bowel disease AC-430 JAK2 0.628838 Simple median 0.67 3.285810e-06 0.135173 HF rs1887428 11 Crohn's disease
940 Valine ROSUVASTATIN ABCG2 0.252397 FE IVW 1.00 3.554664e-06 0.054444 DF rs7655059 30 Crohn's disease
950 Concentration of very large VLDL particles ATORVASTATIN APOE 0.338547 FE IVW 1.00 6.747761e-06 0.075208 DF rs483082 12 Crohn's disease
950 Concentration of very large VLDL particles HMG COA REDUCTASE INHIBITORS LPA 0.338547 FE IVW 1.00 6.747761e-06 0.075208 DF rs74617384 12 Crohn's disease
UKB-a:214 Illnesses of mother: Chronic bronchitis/emphysema POZANICLINE CHRNA5 4.202094 FE IVW 1.00 7.302989e-06 0.936993 DF rs7172118 30 Crohn's disease
496 X-11317 HMG COA REDUCTASE INHIBITORS CETP -1.305394 FE IVW 1.00 9.056721e-06 0.294104 DF rs7499892 30 Crohn's disease
496 X-11317 DALCETRAPIB CETP -1.305394 FE IVW 1.00 9.056721e-06 0.294104 DF rs7499892 30 Crohn's disease
496 X-11317 EVACETRAPIB CETP -1.305394 FE IVW 1.00 9.056721e-06 0.294104 DF rs7499892 30 Crohn's disease
496 X-11317 ANACETRAPIB CETP -1.305394 FE IVW 1.00 9.056721e-06 0.294104 DF rs7499892 30 Crohn's disease
MATCH (trait:Gwas {trait: "Crohn's disease"})<-[mr:MR]-(assoc_trait:Gwas) <-[mre_study_snp:MRE_STUDY_SNP]-(snp:Snp) -[:SNP_GENE]->(gene:Gene) <-[:CPIC|:OPENTARGETS_DRUG_TO_TARGET]-(drug:Drug) WHERE trait.trait <> assoc_trait.trait AND mr.p < 1e-05 AND mre_study_snp.pval < 1e-8 RETURN trait {.id, .trait}, assoc_trait {.id, .trait}, snp {.name}, gene {.name}, drug {.label}, mr {.estimate, .se, .p, .selection, .method, .moescore} ORDER BY mr.p ;
curl -X 'GET' -H 'Accept: */*' -H 'Accept-Encoding: gzip, deflate' -H 'Connection: keep-alive' -H 'User-Agent: python-requests/2.22.0' 'http://api.epigraphdb.org_private/drugs/risk-factors?trait=Crohn%27s+disease&pval_threshold=1e-05'