Drugs for risk factors

Drugs for common risk factors of diseases

Outcome trait

 

P-value threshold: 1e-5
   

 

 

Summary

This view attempts to find potential drugs for a disease outcome via SNPs that influence causal risk factors for that outcome. For a given disease we find potential causal risk factors. For each of those risk factors we take robustly associated genetic variants and map those to gene (this is currently just a physical distance mapping). Drugs that target the products of those genes are then identified using data from Open Targets.

Data sources

  • Gene to drug mappings are taken from Open Targets using their API
  • Causal estimates are from MR-EvE (Hemani et al, Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome, bioRxiv 10.1101/173682)
  • SNP-trait assocaitions are from the IEU GWAS database

How to use

Enter your disease outcome in the Disease trait text box, use the slider to select a p-value threshold for the strength of MR causal evidence, then click Search.

Top results are presented in the Network plot tab, with full results searchable in the Table tab. The Query tab provides information to enable you to download full results using the API.

Examples

 Displays 59 / 59 paths

 

assoc_trait.id assoc_trait.trait drug.label gene.name mr.estimate mr.method mr.moescore mr.p mr.se mr.selection snp.name trait.id trait.trait
339 4-acetamidobutanoate ISOSORBIDE DINITRATE NAT2 1.066106 FE IVW 1.00 0.000000e+00 0.017272 DF rs721399 1102 Chronic kidney disease
339 4-acetamidobutanoate HYDRALAZINE NAT2 1.066106 FE IVW 1.00 0.000000e+00 0.017272 DF rs721399 1102 Chronic kidney disease
339 4-acetamidobutanoate ISONIAZID NAT2 1.066106 FE IVW 1.00 0.000000e+00 0.017272 DF rs721399 1102 Chronic kidney disease
485 X-02269 ROSIGLITAZONE CYP2C8 -0.420750 FE IVW 1.00 1.070111e-283 0.011690 DF rs2071426 1102 Chronic kidney disease
729 X-14626 CERIVASTATIN SLCO1B1 0.272734 FE IVW 1.00 1.643692e-61 0.016481 DF rs12317268 1102 Chronic kidney disease
729 X-14626 SIMVASTATIN SLCO1B1 0.272734 FE IVW 1.00 1.643692e-61 0.016481 DF rs12317268 1102 Chronic kidney disease
729 X-14626 PRAVASTATIN SLCO1B1 0.272734 FE IVW 1.00 1.643692e-61 0.016481 DF rs12317268 1102 Chronic kidney disease
729 X-14626 ROSUVASTATIN SLCO1B1 0.272734 FE IVW 1.00 1.643692e-61 0.016481 DF rs12317268 1102 Chronic kidney disease
729 X-14626 METHOTREXATE SLCO1B1 0.272734 FE IVW 1.00 1.643692e-61 0.016481 DF rs12317268 1102 Chronic kidney disease
UKB-a:75 Non-cancer illness code self-reported: type 2 diabetes SULFONAMIDES TCF7L2 -5.047979 FE IVW 1.00 2.051017e-26 0.474663 DF rs35198068 1102 Chronic kidney disease
856 Omega-6 fatty acids ATORVASTATIN APOE -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs7412 1102 Chronic kidney disease
856 Omega-6 fatty acids HMG COA REDUCTASE INHIBITORS CETP -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs821840 1102 Chronic kidney disease
856 Omega-6 fatty acids DALCETRAPIB CETP -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs821840 1102 Chronic kidney disease
856 Omega-6 fatty acids EVACETRAPIB CETP -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs821840 1102 Chronic kidney disease
856 Omega-6 fatty acids ANACETRAPIB CETP -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs821840 1102 Chronic kidney disease
856 Omega-6 fatty acids EVOLOCUMAB PCSK9 -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs11591147 1102 Chronic kidney disease
856 Omega-6 fatty acids ALIROCUMAB PCSK9 -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs11591147 1102 Chronic kidney disease
856 Omega-6 fatty acids BOCOCIZUMAB PCSK9 -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs11591147 1102 Chronic kidney disease
856 Omega-6 fatty acids RALPANCIZUMAB PCSK9 -0.193506 FE IVW 1.00 3.297300e-10 0.030793 DF rs11591147 1102 Chronic kidney disease
640 X-12696 ACARBOSE MGAM -0.683940 FE IVW 1.00 2.286578e-08 0.122377 DF rs3800993 1102 Chronic kidney disease
640 X-12696 VOGLIBOSE MGAM -0.683940 FE IVW 1.00 2.286578e-08 0.122377 DF rs3800993 1102 Chronic kidney disease
640 X-12696 MIGLITOL MGAM -0.683940 FE IVW 1.00 2.286578e-08 0.122377 DF rs3800993 1102 Chronic kidney disease
519 X-11469 ROSIGLITAZONE CYP2C8 -0.412309 FE IVW 1.00 1.022708e-07 0.077463 DF rs2071426 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) EZOGABINE KCNQ1 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs163160 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) TEDISAMIL KCNQ1 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs163160 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) DALFAMPRIDINE KCNQ1 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs163160 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) NERISPIRDINE KCNQ1 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs163160 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) CARGLUMIC ACID CPS1 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs715 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) VALPROIC ACID CPS1 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs715 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) AZD1305 CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) ATAGABALIN CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) IMAGABALIN CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) SULOCTIDIL CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) ISRADIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) NISOLDIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) CINNARIZINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) NIMODIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) DRONEDARONE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) BEPRIDIL CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) CLEVIDIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) DILTIAZEM CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) NIFEDIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) NICARDIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) VERAPAMIL CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) AMLODIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) FELODIPINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) SEVOFLURANE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) ISOFLURANE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) SUCCINYLCHOLINE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) DESFLURANE CACNA1S -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs3850625 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) EMRICASAN CASP9 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs1800615 1102 Chronic kidney disease
1105 Serum creatinine (eGFRcrea) NIVOCASAN CASP9 -8.254248 Penalised mode 0.72 2.201866e-07 1.309996 DF rs1800615 1102 Chronic kidney disease
862 Glycoproteins RHIGM12B7 PDCD1LG2 -0.177249 Weighted median 0.70 1.494547e-06 0.036835 DF + HF rs142884588 1102 Chronic kidney disease
862 Glycoproteins CARGLUMIC ACID CPS1 -0.177249 Weighted median 0.70 1.494547e-06 0.036835 DF + HF rs1047891 1102 Chronic kidney disease
862 Glycoproteins VALPROIC ACID CPS1 -0.177249 Weighted median 0.70 1.494547e-06 0.036835 DF + HF rs1047891 1102 Chronic kidney disease
449 N-acetylglycine METFORMIN NDUFV1 0.897563 FE IVW 1.00 4.050916e-06 0.194752 DF rs7948073 1102 Chronic kidney disease
449 N-acetylglycine ME-344 NDUFV1 0.897563 FE IVW 1.00 4.050916e-06 0.194752 DF rs7948073 1102 Chronic kidney disease
449 N-acetylglycine CARGLUMIC ACID CPS1 0.897563 FE IVW 1.00 4.050916e-06 0.194752 DF rs715 1102 Chronic kidney disease
449 N-acetylglycine VALPROIC ACID CPS1 0.897563 FE IVW 1.00 4.050916e-06 0.194752 DF rs715 1102 Chronic kidney disease
MATCH (trait:Gwas {trait: "Chronic kidney disease"})<-[mr:MR]-(assoc_trait:Gwas) <-[mre_study_snp:MRE_STUDY_SNP]-(snp:Snp) -[:SNP_GENE]->(gene:Gene) <-[:CPIC|:OPENTARGETS_DRUG_TO_TARGET]-(drug:Drug) WHERE trait.trait <> assoc_trait.trait AND mr.p < 1e-05 AND mre_study_snp.pval < 1e-8 RETURN trait {.id, .trait}, assoc_trait {.id, .trait}, snp {.name}, gene {.name}, drug {.label}, mr {.estimate, .se, .p, .selection, .method, .moescore} ORDER BY mr.p ;
curl -X 'GET' -H 'Accept: */*' -H 'Accept-Encoding: gzip, deflate' -H 'Connection: keep-alive' -H 'User-Agent: python-requests/2.22.0' 'http://api.epigraphdb.org_private/drugs/risk-factors?trait=Chronic+kidney+disease&pval_threshold=1e-05'