Pathway

Pathway-based stratification of instruments

Trait

 

P-value threshold: 1e-5
   

 

 

 Summary

This is a pilot view to explore the potential of pathway data to inform us about groups of SNPs that may share pleiotropic relationships. For a trait we identify all SNPs that can be mapped to genes/proteins, and from those genes/proteins we look for common pathways.

Data sources

  • Gene/protein to pathway mappings from Reactome
  • MR estimates from MR-EvE (Hemani et al, Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome, bioRxiv 10.1101/173682)
  • SNP-trait assocaitions are from the IEU GWAS database

 How to use

Enter the trait you are interested in, the p-value threshold you want to use, then press "Search". You can adjust the slider and press Search again to update the results.

View the top results in the Network plot tab, access and search the full results in the Table tab, or use the Query tab to find out how to download data using the API.

 Examples

 Displays 141 / 141 paths

 

gwas.id gwas.trait mre_study_snp.beta mre_study_snp.se mre_study_snp.eaf mre_study_snp.pval mre_study_snp.samplesize snp.name gene.name protein.uniprot_id pathway.reactome_id pathway.name
1239 Years of schooling -0.020160 0.001770 0.57990 3.349654e-30 766345.0 rs34316 MEF2C Q06413 R-HSA-375170 CDO in myogenesis
1239 Years of schooling -0.020160 0.001770 0.57990 3.349654e-30 766345.0 rs34316 MEF2C Q06413 R-HSA-198753 ERK/MAPK targets
1239 Years of schooling -0.020160 0.001770 0.57990 3.349654e-30 766345.0 rs34316 MEF2C Q06413 R-HSA-9022707 MECP2 regulates transcription factors
1239 Years of schooling -0.020460 0.001950 0.69050 1.139987e-25 766345.0 rs1620977 NEGR1 Q7Z3B1 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
1239 Years of schooling -0.018280 0.001770 0.66160 5.460092e-25 766345.0 rs2819336 PTPRF P10586 R-HSA-8849932 Synaptic adhesion-like molecules
1239 Years of schooling -0.018280 0.001770 0.66160 5.460092e-25 766345.0 rs2819336 PTPRF P10586 R-HSA-388844 Receptor-type tyrosine-protein phosphatases
1239 Years of schooling 0.016360 0.001850 0.69900 1.009950e-18 766345.0 rs4382592 MED27 Q6P2C8 R-HSA-212436 Generic Transcription Pathway
1239 Years of schooling 0.015670 0.001810 0.72450 4.149540e-18 766345.0 rs6557171 ESR1 P03372 R-HSA-383280 Nuclear Receptor transcription pathway
1239 Years of schooling 0.015670 0.001810 0.72450 4.149540e-18 766345.0 rs6557171 ESR1 P03372 R-HSA-8939211 ESR-mediated signaling
1239 Years of schooling 0.015670 0.001810 0.72450 4.149540e-18 766345.0 rs6557171 ESR1 P03372 R-HSA-5689896 Ovarian tumor domain proteases
1239 Years of schooling 0.015670 0.001810 0.72450 4.149540e-18 766345.0 rs6557171 ESR1 P03372 R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
1239 Years of schooling 0.015670 0.001810 0.72450 4.149540e-18 766345.0 rs6557171 ESR1 P03372 R-HSA-4090294 SUMOylation of intracellular receptors
1239 Years of schooling -0.018210 0.002130 0.23980 1.310087e-17 766345.0 rs74998289 CRHR1 P34998 R-HSA-373080 Class B/2 (Secretin family receptors)
1239 Years of schooling 0.014770 0.001740 0.52040 2.220240e-17 766345.0 rs1618725 NPC1 O15118 R-HSA-8964038 LDL clearance
1239 Years of schooling 0.014880 0.001760 0.39630 2.619992e-17 766345.0 rs10765775 MTMR2 Q13614 R-HSA-1483248 Synthesis of PIPs at the ER membrane
1239 Years of schooling 0.014880 0.001760 0.39630 2.619992e-17 766345.0 rs10765775 MTMR2 Q13614 R-HSA-1660499 Synthesis of PIPs at the plasma membrane
1239 Years of schooling 0.014880 0.001760 0.39630 2.619992e-17 766345.0 rs10765775 MTMR2 Q13614 R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
1239 Years of schooling 0.018150 0.002170 0.19050 5.790286e-17 766345.0 rs62444881 MAD1L1 Q9Y6D9 R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
1239 Years of schooling 0.015180 0.001840 0.31120 1.609904e-16 766345.0 rs12643771 MAML3 Q96JK9 R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
1239 Years of schooling 0.015180 0.001840 0.31120 1.609904e-16 766345.0 rs12643771 MAML3 Q96JK9 R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
1239 Years of schooling 0.015180 0.001840 0.31120 1.609904e-16 766345.0 rs12643771 MAML3 Q96JK9 R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
1239 Years of schooling 0.015180 0.001840 0.31120 1.609904e-16 766345.0 rs12643771 MAML3 Q96JK9 R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
1239 Years of schooling 0.015180 0.001840 0.31120 1.609904e-16 766345.0 rs12643771 MAML3 Q96JK9 R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
1239 Years of schooling 0.015180 0.001840 0.31120 1.609904e-16 766345.0 rs12643771 MAML3 Q96JK9 R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
1239 Years of schooling 0.015180 0.001840 0.31120 1.609904e-16 766345.0 rs12643771 MAML3 Q96JK9 R-HSA-350054 Notch-HLH transcription pathway
1239 Years of schooling 0.014310 0.001740 0.41670 1.630047e-16 766345.0 rs55736314 FOXP1 Q9H334 R-HSA-452723 Transcriptional regulation of pluripotent stem cells
1001 Years of schooling 0.036000 0.004000 0.08769 2.344229e-16 293723.0 rs34305371 NEGR1 Q7Z3B1 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
1239 Years of schooling 0.016540 0.002070 0.77210 1.249971e-15 766345.0 rs2971970 EXOC4 Q96A65 R-HSA-264876 Insulin processing
1239 Years of schooling -0.015280 0.001910 0.24490 1.279971e-15 766345.0 rs62184480 ERBB4 Q15303 R-HSA-1236394 Signaling by ERBB4
1239 Years of schooling 0.015710 0.001970 0.23810 1.339985e-15 766345.0 rs56391344 LINGO1 Q96FE5 R-HSA-193634 Axonal growth inhibition (RHOA activation)
1239 Years of schooling -0.013850 0.001740 0.38950 1.699809e-15 766345.0 rs6493265 SEMA6D Q8NFY4 R-HSA-416700 Other semaphorin interactions
1239 Years of schooling 0.013630 0.001720 0.57480 2.039858e-15 766345.0 rs363096 HTT P42858 R-HSA-9022692 Regulation of MECP2 expression and activity
1239 Years of schooling -0.013460 0.001710 0.49490 3.110284e-15 766345.0 rs2545798 GRK6 P43250 R-HSA-418555 G alpha (s) signalling events
1239 Years of schooling -0.015960 0.002060 0.24660 9.880980e-15 766345.0 rs34853711 MAD1L1 Q9Y6D9 R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
1239 Years of schooling -0.015370 0.001990 0.28400 1.050026e-14 766345.0 rs3026996 CADM3 Q8N126 R-HSA-420597 Nectin/Necl trans heterodimerization
1239 Years of schooling 0.013210 0.001710 0.46600 1.150006e-14 766345.0 rs35309068 ATF7IP Q6VMQ6 R-HSA-3214841 PKMTs methylate histone lysines
1239 Years of schooling 0.014100 0.001840 0.65140 1.810089e-14 766345.0 rs4757957 TEAD1 P28347 R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
1239 Years of schooling 0.028920 0.003810 0.06122 3.299894e-14 766345.0 rs115000530 MITF O75030 R-HSA-3232118 SUMOylation of transcription factors
1239 Years of schooling 0.018730 0.002480 0.13100 4.400479e-14 766345.0 rs76076331 PDIA6 Q15084 R-HSA-381038 XBP1(S) activates chaperone genes
1239 Years of schooling -0.012880 0.001720 0.41160 6.060382e-14 766345.0 rs62097985 DCC P43146 R-HSA-373752 Netrin-1 signaling
1239 Years of schooling -0.012880 0.001720 0.41160 6.060382e-14 766345.0 rs62097985 DCC P43146 R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand
1239 Years of schooling -0.012880 0.001720 0.41160 6.060382e-14 766345.0 rs62097985 DCC P43146 R-HSA-418885 DCC mediated attractive signaling
1239 Years of schooling -0.012880 0.001720 0.41160 6.060382e-14 766345.0 rs62097985 DCC P43146 R-HSA-418886 Netrin mediated repulsion signals
1239 Years of schooling -0.012880 0.001720 0.41160 6.060382e-14 766345.0 rs62097985 DCC P43146 R-HSA-376172 DSCAM interactions
1239 Years of schooling -0.012880 0.001720 0.41160 6.060382e-14 766345.0 rs62097985 DCC P43146 R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
1239 Years of schooling 0.012720 0.001750 0.63440 3.570261e-13 766345.0 rs4810227 CDH4 P55283 R-HSA-418990 Adherens junctions interactions
1239 Years of schooling -0.015110 0.002080 0.18370 3.800144e-13 766345.0 rs35475880 MECOM Q03112 R-HSA-8943724 Regulation of PTEN gene transcription
1239 Years of schooling -0.014770 0.002120 0.20410 2.890014e-12 766345.0 rs17563464 CDH9 Q9ULB4 R-HSA-418990 Adherens junctions interactions
1239 Years of schooling -0.014130 0.002030 0.19730 3.090295e-12 766345.0 rs6805241 LSAMP Q13449 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
1001 Years of schooling 0.018000 0.003000 0.33400 3.798394e-12 293723.0 rs4863692 MAML3 Q96JK9 R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
1001 Years of schooling 0.018000 0.003000 0.33400 3.798394e-12 293723.0 rs4863692 MAML3 Q96JK9 R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
1001 Years of schooling 0.018000 0.003000 0.33400 3.798394e-12 293723.0 rs4863692 MAML3 Q96JK9 R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
1001 Years of schooling 0.018000 0.003000 0.33400 3.798394e-12 293723.0 rs4863692 MAML3 Q96JK9 R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
1001 Years of schooling 0.018000 0.003000 0.33400 3.798394e-12 293723.0 rs4863692 MAML3 Q96JK9 R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
1001 Years of schooling 0.018000 0.003000 0.33400 3.798394e-12 293723.0 rs4863692 MAML3 Q96JK9 R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
1001 Years of schooling 0.018000 0.003000 0.33400 3.798394e-12 293723.0 rs4863692 MAML3 Q96JK9 R-HSA-350054 Notch-HLH transcription pathway
1239 Years of schooling 0.013040 0.001920 0.28570 1.020000e-11 766345.0 rs113520408 CALU O43852 R-HSA-114608 Platelet degranulation
1239 Years of schooling -0.011520 0.001710 0.53400 1.530030e-11 766345.0 rs2287838 PIN1 Q13526 R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
1239 Years of schooling -0.011520 0.001710 0.53400 1.530030e-11 766345.0 rs2287838 PIN1 Q13526 R-HSA-6811555 PI5P Regulates TP53 Acetylation
1239 Years of schooling -0.011520 0.001710 0.53400 1.530030e-11 766345.0 rs2287838 PIN1 Q13526 R-HSA-1169408 ISG15 antiviral mechanism
1001 Years of schooling 0.017000 0.002000 0.45710 1.992049e-11 293723.0 rs7964899 ATF7IP Q6VMQ6 R-HSA-3214841 PKMTs methylate histone lysines
1239 Years of schooling 0.017010 0.002550 0.88610 2.369736e-11 766345.0 rs12602286 EPN2 O95208 R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
1239 Years of schooling 0.014850 0.002240 0.18200 3.670287e-11 766345.0 rs10456918 ASF1A Q9Y294 R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
1239 Years of schooling 0.012080 0.001850 0.68710 6.120685e-11 766345.0 rs8008382 KLC1 Q07866 R-HSA-983189 Kinesins
1001 Years of schooling 0.016000 0.003000 0.60260 1.109992e-10 293723.0 rs34344888 PRMT5 O14744 R-HSA-6804760 Regulation of TP53 Activity through Methylation
1001 Years of schooling 0.016000 0.003000 0.60260 1.109992e-10 293723.0 rs34344888 PRMT5 O14744 R-HSA-3214858 RMTs methylate histone arginines
1001 Years of schooling 0.016000 0.003000 0.61750 1.201988e-10 293723.0 rs1378214 SEMA6D Q8NFY4 R-HSA-416700 Other semaphorin interactions
1239 Years of schooling 0.011230 0.001750 0.57650 1.339985e-10 766345.0 rs2052285 SALL1 Q9NSC2 R-HSA-2892247 POU5F1 (OCT4),SOX2,NANOG activate genes related to proliferation
1011 Years of schooling 0.023000 0.004000 0.33210 1.396015e-10 162028.0 rs795980 MAML3 Q96JK9 R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
1011 Years of schooling 0.023000 0.004000 0.33210 1.396015e-10 162028.0 rs795980 MAML3 Q96JK9 R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
1011 Years of schooling 0.023000 0.004000 0.33210 1.396015e-10 162028.0 rs795980 MAML3 Q96JK9 R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
1011 Years of schooling 0.023000 0.004000 0.33210 1.396015e-10 162028.0 rs795980 MAML3 Q96JK9 R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
1011 Years of schooling 0.023000 0.004000 0.33210 1.396015e-10 162028.0 rs795980 MAML3 Q96JK9 R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
1011 Years of schooling 0.023000 0.004000 0.33210 1.396015e-10 162028.0 rs795980 MAML3 Q96JK9 R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
1011 Years of schooling 0.023000 0.004000 0.33210 1.396015e-10 162028.0 rs795980 MAML3 Q96JK9 R-HSA-350054 Notch-HLH transcription pathway
1239 Years of schooling 0.010920 0.001700 0.49320 1.430013e-10 766345.0 rs837080 FAM49B Q9NUQ9 R-HSA-114608 Platelet degranulation
1239 Years of schooling -0.011770 0.001850 0.27890 1.880009e-10 766345.0 rs6513959 STK4 Q13043 R-HSA-2028269 Signaling by Hippo
1239 Years of schooling -0.010800 0.001700 0.52890 2.380017e-10 766345.0 rs9556958 STK24 Q9Y6E0 R-HSA-111465 Apoptotic cleavage of cellular proteins
1239 Years of schooling -0.010800 0.001700 0.52890 2.380017e-10 766345.0 rs9556958 STK24 Q9Y6E0 R-HSA-75153 Apoptotic execution phase
1239 Years of schooling -0.012510 0.002000 0.25000 3.940034e-10 766345.0 rs4839155 RAP1A P62834 R-HSA-6798695 Neutrophil degranulation
1239 Years of schooling 0.010750 0.001730 0.38950 5.669960e-10 766345.0 rs34485537 CDH13 P55290 R-HSA-418990 Adherens junctions interactions
1011 Years of schooling 0.036000 0.006000 0.08769 7.888964e-10 162028.0 rs34305371 NEGR1 Q7Z3B1 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
1239 Years of schooling 0.010720 0.001780 0.66500 1.559983e-09 766345.0 rs7481514 NTM Q9P121 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
1239 Years of schooling 0.010970 0.001820 0.35540 1.590011e-09 766345.0 rs12955211 CDH2 P19022 R-HSA-418990 Adherens junctions interactions
1239 Years of schooling -0.011730 0.001950 0.24490 1.670014e-09 766345.0 rs1105307 APBA1 Q02410 R-HSA-212676 Dopamine Neurotransmitter Release Cycle
1001 Years of schooling -0.015000 0.002000 0.50190 1.890993e-09 293723.0 rs9556958 STK24 Q9Y6E0 R-HSA-111465 Apoptotic cleavage of cellular proteins
1001 Years of schooling -0.015000 0.002000 0.50190 1.890993e-09 293723.0 rs9556958 STK24 Q9Y6E0 R-HSA-75153 Apoptotic execution phase
1011 Years of schooling -0.025000 0.004000 0.20150 1.962005e-09 162028.0 rs11191270 GBF1 Q92538 R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
1011 Years of schooling -0.025000 0.004000 0.20150 1.962005e-09 162028.0 rs11191270 GBF1 Q92538 R-HSA-6807878 COPI-mediated anterograde transport
1001 Years of schooling 0.015000 0.002000 0.45710 2.130002e-09 293723.0 rs4800490 NPC1 O15118 R-HSA-8964038 LDL clearance
1239 Years of schooling 0.010530 0.001770 0.65650 2.959988e-09 766345.0 rs710629 CAND1 Q86VP6 R-HSA-6798695 Neutrophil degranulation
1239 Years of schooling 0.010530 0.001770 0.65650 2.959988e-09 766345.0 rs710629 CAND1 Q86VP6 R-HSA-917937 Iron uptake and transport
1239 Years of schooling 0.010530 0.001770 0.65650 2.959988e-09 766345.0 rs710629 CAND1 Q86VP6 R-HSA-8951664 Neddylation
1239 Years of schooling -0.035210 0.005970 0.01190 3.790007e-09 766345.0 rs117468730 GRIN2A Q12879 R-HSA-9022699 MECP2 regulates neuronal receptors and channels
1239 Years of schooling 0.013830 0.002350 0.14120 4.130000e-09 766345.0 rs61747885 MAML3 Q96JK9 R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
1239 Years of schooling 0.013830 0.002350 0.14120 4.130000e-09 766345.0 rs61747885 MAML3 Q96JK9 R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
1239 Years of schooling 0.013830 0.002350 0.14120 4.130000e-09 766345.0 rs61747885 MAML3 Q96JK9 R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
1239 Years of schooling 0.013830 0.002350 0.14120 4.130000e-09 766345.0 rs61747885 MAML3 Q96JK9 R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
1239 Years of schooling 0.013830 0.002350 0.14120 4.130000e-09 766345.0 rs61747885 MAML3 Q96JK9 R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
1239 Years of schooling 0.013830 0.002350 0.14120 4.130000e-09 766345.0 rs61747885 MAML3 Q96JK9 R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
1239 Years of schooling 0.013830 0.002350 0.14120 4.130000e-09 766345.0 rs61747885 MAML3 Q96JK9 R-HSA-350054 Notch-HLH transcription pathway
1010 Years of schooling 0.038000 0.007000 0.08769 4.513048e-09 131695.0 rs34305371 NEGR1 Q7Z3B1 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
1239 Years of schooling 0.010230 0.001750 0.37760 4.709990e-09 766345.0 rs17110109 CBX5 P45973 R-HSA-8953750 Transcriptional Regulation by E2F6
1239 Years of schooling 0.010230 0.001750 0.37760 4.709990e-09 766345.0 rs17110109 CBX5 P45973 R-HSA-4551638 SUMOylation of chromatin organization proteins
1239 Years of schooling 0.010230 0.001750 0.37760 4.709990e-09 766345.0 rs17110109 CBX5 P45973 R-HSA-983231 Factors involved in megakaryocyte development and platelet production
755 Years of schooling 0.027594 0.004715 0.00000 4.848976e-09 106736.0 rs9858213 MST1 P26927 R-HSA-8852405 Signaling by MST1
1239 Years of schooling -0.015320 0.002620 0.13440 5.049984e-09 766345.0 rs7833201 CPNE3 O75131 R-HSA-6798695 Neutrophil degranulation
1239 Years of schooling -0.015320 0.002620 0.13440 5.049984e-09 766345.0 rs7833201 CPNE3 O75131 R-HSA-1483206 Glycerophospholipid biosynthesis
1239 Years of schooling -0.010050 0.001740 0.61220 7.389924e-09 766345.0 rs663234 DAB1 O75553 R-HSA-8866376 Reelin signalling pathway
1239 Years of schooling -0.027690 0.004820 0.02211 9.470000e-09 766345.0 rs77128898 SYT7 O43581 R-HSA-6794361 Neurexins and neuroligins
1239 Years of schooling 0.010190 0.001770 0.38610 9.470000e-09 766345.0 rs152603 EFNA5 P52803 R-HSA-2682334 EPH-Ephrin signaling
1239 Years of schooling 0.010190 0.001770 0.38610 9.470000e-09 766345.0 rs152603 EFNA5 P52803 R-HSA-3928665 EPH-ephrin mediated repulsion of cells
1001 Years of schooling 0.018000 0.003000 0.80040 9.582967e-09 293723.0 rs1424580 EXOC4 Q96A65 R-HSA-264876 Insulin processing
1001 Years of schooling 0.015000 0.003000 0.41600 1.089005e-08 293723.0 rs523934 MTMR2 Q13614 R-HSA-1483248 Synthesis of PIPs at the ER membrane
1001 Years of schooling 0.015000 0.003000 0.41600 1.089005e-08 293723.0 rs523934 MTMR2 Q13614 R-HSA-1660499 Synthesis of PIPs at the plasma membrane
1001 Years of schooling 0.015000 0.003000 0.41600 1.089005e-08 293723.0 rs523934 MTMR2 Q13614 R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
1001 Years of schooling -0.014000 0.003000 0.39930 1.109992e-08 293723.0 rs62100767 DCC P43146 R-HSA-373752 Netrin-1 signaling
1001 Years of schooling -0.014000 0.003000 0.39930 1.109992e-08 293723.0 rs62100767 DCC P43146 R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand
1001 Years of schooling -0.014000 0.003000 0.39930 1.109992e-08 293723.0 rs62100767 DCC P43146 R-HSA-418885 DCC mediated attractive signaling
1001 Years of schooling -0.014000 0.003000 0.39930 1.109992e-08 293723.0 rs62100767 DCC P43146 R-HSA-418886 Netrin mediated repulsion signals
1001 Years of schooling -0.014000 0.003000 0.39930 1.109992e-08 293723.0 rs62100767 DCC P43146 R-HSA-376172 DSCAM interactions
1001 Years of schooling -0.014000 0.003000 0.39930 1.109992e-08 293723.0 rs62100767 DCC P43146 R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
1239 Years of schooling -0.011850 0.002080 0.18200 1.199997e-08 766345.0 rs743316 ITSN1 Q15811 R-HSA-8856828 Clathrin-mediated endocytosis
1239 Years of schooling -0.011850 0.002080 0.18200 1.199997e-08 766345.0 rs743316 ITSN1 Q15811 R-HSA-3928662 EPHB-mediated forward signaling
1001 Years of schooling 0.015000 0.003000 0.59700 1.225011e-08 293723.0 rs10831912 TEAD1 P28347 R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
837 Years of schooling -0.023000 0.004000 0.44000 1.862001e-08 126559.0 rs1056667 BTN1A1 Q13410 R-HSA-8851680 Butyrophilin (BTN) family interactions
1010 Years of schooling -0.026000 0.005000 0.17910 1.932013e-08 131695.0 rs12462428 MED26 O95402 R-HSA-212436 Generic Transcription Pathway
1001 Years of schooling -0.016000 0.003000 0.22570 2.138996e-08 293723.0 rs7033137 APBA1 Q02410 R-HSA-212676 Dopamine Neurotransmitter Release Cycle
1239 Years of schooling 0.010070 0.001810 0.35540 2.509978e-08 766345.0 rs16854920 NFASC O94856 R-HSA-6798695 Neutrophil degranulation
1239 Years of schooling 0.010070 0.001810 0.35540 2.509978e-08 766345.0 rs16854920 NFASC O94856 R-HSA-447043 Neurofascin interactions
1001 Years of schooling 0.014000 0.003000 0.42350 2.587021e-08 293723.0 rs4468571 LINGO1 Q96FE5 R-HSA-193634 Axonal growth inhibition (RHOA activation)
837 Years of schooling -0.022000 0.004000 0.51000 3.596003e-08 126559.0 rs7309 TANK Q92844 R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
837 Years of schooling -0.022000 0.004000 0.51000 3.596003e-08 126559.0 rs7309 TANK Q92844 R-HSA-933541 TRAF6 mediated IRF7 activation
837 Years of schooling -0.022000 0.004000 0.51000 3.596003e-08 126559.0 rs7309 TANK Q92844 R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7
1001 Years of schooling 0.014000 0.002000 0.43470 3.741967e-08 293723.0 rs7146434 ESR2 Q92731 R-HSA-383280 Nuclear Receptor transcription pathway
1001 Years of schooling 0.014000 0.002000 0.43470 3.741967e-08 293723.0 rs7146434 ESR2 Q92731 R-HSA-8939211 ESR-mediated signaling
1239 Years of schooling 0.009410 0.001710 0.51700 3.769988e-08 766345.0 rs2901616 NEGR1 Q7Z3B1 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
1239 Years of schooling -0.009520 0.001740 0.37760 4.150018e-08 766345.0 rs4888746 WWOX Q9NZC7 R-HSA-1251985 Nuclear signaling by ERBB4
1239 Years of schooling -0.009520 0.001740 0.37760 4.150018e-08 766345.0 rs4888746 WWOX Q9NZC7 R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
1001 Years of schooling 0.014000 0.003000 0.34330 4.832034e-08 293723.0 rs152590 EFNA5 P52803 R-HSA-2682334 EPH-Ephrin signaling
1001 Years of schooling 0.014000 0.003000 0.34330 4.832034e-08 293723.0 rs152590 EFNA5 P52803 R-HSA-3928665 EPH-ephrin mediated repulsion of cells
MATCH (gwas:Gwas {trait: "Years of schooling"}) <-[mre_study_snp:MRE_STUDY_SNP]-(snp:Snp)-[snp_gene:SNP_GENE]-> (gene:Gene)-[gene_to_protein:GENE_TO_PROTEIN]->(protein:Protein) -[protein_in_pathway:PROTEIN_IN_PATHWAY]->(pathway:Pathway) WHERE mre_study_snp.pval < 1e-05 AND snp.name is not null AND gene.name is not null RETURN gwas {.id, .trait}, mre_study_snp {.se, .eaf, .pval, .samplesize, .beta}, snp {.name}, gene {.name}, protein {.uniprot_id}, pathway {.reactome_id, .name} ORDER BY mre_study_snp.pval ;
curl -X 'GET' -H 'Accept: */*' -H 'Accept-Encoding: gzip, deflate' -H 'Connection: keep-alive' -H 'User-Agent: python-requests/2.22.0' 'http://api.epigraphdb.org_private/pathway?trait_name=Years+of+schooling&pval_threshold=1e-05'