MR causal estimate

Pre-computed Mendelian randomization results

 

Exposure trait

 

P-value threshold: 1e-5
   
Outcome trait

 

P-value threshold: 1e-5
   
Exposure trait
Outcome trait

 

P-value threshold: 1e-5
   

 

 

Summary

This view provides automated causal estimates between pairs of traits using the results from MR-EvE (Hemani et al, bioRxiv 10.1101/173682). Note that these are preliminary results generated using an automated algorithm, so should always be validated by performing an analysis with MR-Base.

Three views are available:

  • Searching for anything that an exposure might cause
  • Searching for anything that might cause an outcome
  • Retrieving the causal estimate between a single exposure and outcome

The Query tab shows how this query works and provides the API call to replicate this programmatically.

Data sources

  • MR-EvE (Hemani et al, Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome, bioRxiv 10.1101/173682)

How to use

All three approaches comprise a search form in which you enter trait values and select a threshold. After clicking search you can view the top results in the Network plot tab or the full set of results in the Table tab. The Query tab provides the information you need to download the data using the API.

The three views are accessed by pressing one of the three buttons: Search exposure trait, Search outcome trait or Search exposure and outcome traits.

Once you have selected a view, enter the trait name(s), select a p-value threshold, then click Search.

View the top results in the Network plot tab, access and search the full results in the Table tab, or use the Query tab to find out how to download data using the API.

Changing the threshold: If you move the slider you will need to click Search again to apply the new threshold

Examples

The following examples illustrate the three types of search:

 Displays 50 / 370 paths

 

outcome_id outcome_name exposure_id exposure_name estimate se p ci_low ci_upp method selection moescore
785 Body mass index 627 Epiandrosterone sulfate 0.095004 0.002280 0.000000e+00 0.090535 0.099473 FE IVW DF 1.00
835 Body mass index 541 X-11787 -0.057769 0.000177 0.000000e+00 -0.058116 -0.057422 FE IVW DF 1.00
835 Body mass index 971 Ulcerative colitis -0.011053 0.000176 0.000000e+00 -0.011398 -0.010709 FE IVW DF 1.00
835 Body mass index 60 Waist circumference 0.860649 0.020650 0.000000e+00 0.820174 0.901124 FE IVW DF + HF 0.88
94 Body mass index UKB-a:426 Eye problems/disorders: Cataract -1.115443 0.019043 0.000000e+00 -1.152767 -1.078118 FE IVW DF 1.00
95 Body mass index UKB-a:373 Ever depressed for a whole week -0.615976 0.000480 0.000000e+00 -0.616917 -0.615036 FE IVW DF 1.00
95 Body mass index 29 Birth length -0.140790 0.000567 0.000000e+00 -0.141901 -0.139679 FE IVW DF 1.00
974 Body mass index 350 Laurate (12:0) 0.417617 0.007104 0.000000e+00 0.403693 0.431541 FE IVW DF 1.00
974 Body mass index UKB-a:124 Treatment/medication code: becotide 50 inhaler -5.139005 0.108362 0.000000e+00 -5.351394 -4.926616 FE IVW DF 1.00
974 Body mass index 95 Body mass index 0.980908 0.027925 2.639583e-270 0.926176 1.035641 FE IVW HF 0.74
835 Body mass index UKB-a:295 Chest pain or discomfort -0.313110 0.009700 1.401238e-228 -0.332123 -0.294098 FE IVW DF 1.00
94 Body mass index 2 Body mass index 0.857565 0.027974 2.188032e-206 0.802737 0.912394 FE IVW DF + HF 0.92
785 Body mass index UKB-a:185 Treatment/medication code: arcoxia 90mg tablet 14.436167 0.474543 2.878732e-203 13.506064 15.366271 FE IVW DF 1.00
785 Body mass index UKB-a:323 Age started oral contraceptive pill -0.096109 0.003443 1.914373e-171 -0.102857 -0.089360 FE IVW DF 1.00
94 Body mass index UKB-a:41 Father's age at death -0.717614 0.026113 2.959549e-166 -0.768795 -0.666432 FE IVW DF 1.00
95 Body mass index 642 X-12712 0.169149 0.006341 9.484571e-157 0.156720 0.181578 FE IVW DF 1.00
835 Body mass index 85 Extreme body mass index 0.237366 0.009596 4.361716e-135 0.218558 0.256173 FE IVW HF 0.72
95 Body mass index 51 Hip circumference 0.929249 0.037779 1.366521e-133 0.855202 1.003297 FE IVW DF + HF 0.82
95 Body mass index 63 Waist circumference 0.929249 0.037779 1.366521e-133 0.855202 1.003297 FE IVW DF + HF 0.82
835 Body mass index 638 Asparagine -0.215321 0.008783 1.019592e-132 -0.232536 -0.198106 FE IVW DF 1.00
835 Body mass index 64 Waist circumference 0.973324 0.040819 1.148909e-125 0.844925 1.101723 FE IVW Tophits 0.75
2 Body mass index 785 Body mass index 0.828436 0.034942 2.916750e-124 0.759950 0.896922 FE IVW DF 0.87
974 Body mass index 835 Body mass index 1.012590 0.042868 2.329665e-123 0.928571 1.096609 Simple median Tophits 0.92
94 Body mass index 29 Birth length 0.041067 0.001814 1.589312e-113 0.037513 0.044622 FE IVW DF 1.00
785 Body mass index 539 ADSGEGDFXAEGGGVR* -0.058850 0.002689 3.541739e-106 -0.064120 -0.053580 FE IVW DF 1.00
95 Body mass index 62 Waist circumference 1.019881 0.047350 6.715630e-103 0.927074 1.112688 FE IVW Tophits 0.79
974 Body mass index 670 X-12855 -0.108112 0.005041 4.817848e-102 -0.117992 -0.098232 FE IVW DF 1.00
835 Body mass index 2 Body mass index 1.009931 0.047113 6.100470e-102 0.917592 1.102270 Penalised median HF 0.79
2 Body mass index 971 Ulcerative colitis -0.011570 0.000541 1.284948e-101 -0.012630 -0.010510 FE IVW DF 1.00
785 Body mass index 601 ADpSGEGDFXAEGGGVR* -0.104923 0.004987 2.799702e-98 -0.114697 -0.095149 FE IVW DF 1.00
974 Body mass index 307 Cholesterol -0.611157 0.029590 8.967038e-95 -0.669153 -0.553160 FE IVW DF 1.00
95 Body mass index 748 4-androsten-3beta,17beta-diol disulfate 2* -0.035648 0.001797 1.327270e-87 -0.039170 -0.032127 FE IVW DF 1.00
2 Body mass index 974 Body mass index 0.856419 0.043934 1.255138e-84 0.770309 0.942529 Simple median HF 0.87
785 Body mass index 95 Body mass index 0.776870 0.039951 3.162581e-84 0.698567 0.855173 FE IVW DF + HF 0.68
95 Body mass index UKB-a:124 Treatment/medication code: becotide 50 inhaler -8.484168 0.437681 1.046163e-83 -9.342023 -7.626312 FE IVW DF 1.00
785 Body mass index 65 Waist circumference 1.071496 0.056047 1.789800e-81 0.961645 1.181348 FE IVW HF 0.76
974 Body mass index 51 Hip circumference 1.037371 0.054320 2.654135e-81 0.930904 1.143838 FE IVW HF 0.73
974 Body mass index 63 Waist circumference 1.037371 0.054320 2.654135e-81 0.930904 1.143838 FE IVW HF 0.73
785 Body mass index 2 Body mass index 0.894302 0.047054 1.523061e-80 0.802078 0.986526 Weighted median DF 0.87
785 Body mass index 91 Obesity class 2 0.256252 0.013681 2.783964e-78 0.229437 0.283066 FE IVW HF 0.69
835 Body mass index 974 Body mass index 0.871570 0.047573 5.647616e-75 0.778329 0.964811 Simple median HF 0.92
974 Body mass index 50 Hip circumference 0.764752 0.041886 1.787176e-74 0.600804 0.928700 FE IVW Tophits 0.71
974 Body mass index 60 Waist circumference 0.980909 0.054433 1.348071e-72 0.874222 1.087596 Simple median Tophits 0.88
95 Body mass index 48 Hip circumference 0.766352 0.042913 2.500677e-71 0.647918 0.884785 FE IVW Tophits 0.90
95 Body mass index 974 Body mass index 0.971723 0.054441 2.932217e-71 0.865021 1.078424 Simple median Tophits 0.88
2 Body mass index 751 Palmitoyl sphingomyelin -0.310878 0.017533 2.401902e-70 -0.345242 -0.276514 FE IVW DF 1.00
835 Body mass index 90 Obesity class 1 0.348926 0.019936 1.373343e-68 0.309853 0.388000 Simple median Tophits 0.83
835 Body mass index 49 Hip circumference 0.508519 0.029388 4.429792e-67 0.393828 0.623209 FE IVW DF 0.80
2 Body mass index 50 Hip circumference 0.589548 0.034961 8.388933e-64 0.443595 0.735502 FE IVW DF 0.75
835 Body mass index 65 Waist circumference 1.048331 0.062355 1.985022e-63 0.926117 1.170545 Weighted median Tophits 0.78
835 Body mass index 785 Body mass index 0.895307 0.053390 4.090752e-63 0.790665 0.999948 Simple median HF 0.80
974 Body mass index 2 Body mass index 1.012872 0.014005 2.426885e-62 0.985421 1.040322 Simple mean HF 0.90
2 Body mass index 90 Obesity class 1 0.340000 0.020444 4.177422e-62 0.299930 0.380070 Simple median HF 0.80
974 Body mass index 49 Hip circumference 0.667819 0.041377 1.336907e-58 0.584175 0.751463 FE IVW DF + HF 0.85
2 Body mass index UKB-a:344 Difficulty not smoking for 1 day -0.122985 0.007653 4.147893e-58 -0.137985 -0.107985 FE IVW DF 1.00
95 Body mass index 85 Extreme body mass index 0.222493 0.014133 7.740637e-56 0.194791 0.250194 FE IVW HF 0.79
2 Body mass index 60 Waist circumference 0.921053 0.058517 8.045873e-56 0.806362 1.035743 Simple median Tophits 0.88
95 Body mass index 2 Body mass index 1.024385 0.021912 4.510179e-55 0.981437 1.067333 Simple mean HF 0.92
974 Body mass index 65 Waist circumference 0.738726 0.047371 7.928597e-55 0.645879 0.831572 FE IVW DF + HF 0.80
2 Body mass index 91 Obesity class 2 0.258652 0.016835 2.875517e-53 0.225655 0.291649 Penalised median HF 0.81
974 Body mass index 90 Obesity class 1 0.360173 0.023599 1.366487e-52 0.313920 0.406427 Simple median Tophits 0.80
94 Body mass index 785 Body mass index 0.976562 0.064276 3.913645e-52 0.850585 1.102540 Simple median Tophits 0.86
835 Body mass index 91 Obesity class 2 0.268615 0.017957 1.360872e-50 0.233420 0.303809 Penalised median HF 0.77
785 Body mass index 835 Body mass index 0.946255 0.016970 2.036356e-49 0.912993 0.979516 RE IVW HF 0.90
95 Body mass index 495 X-11315 -0.339460 0.023007 2.870069e-49 -0.384553 -0.294366 FE IVW DF 1.00
974 Body mass index UKB-a:72 Non-cancer illness code self-reported: kidney stone/ureter stone/bladder stone -2.638412 0.179359 5.544952e-49 -2.989956 -2.286867 FE IVW DF 1.00
835 Body mass index 94 Body mass index 0.905647 0.061997 2.500317e-48 0.784135 1.027159 Weighted median Tophits 0.69
974 Body mass index 761 Corrected insulin response 0.066057 0.004532 4.020921e-48 0.057174 0.074940 FE IVW DF 1.00
974 Body mass index 785 Body mass index 0.812274 0.055901 7.757418e-48 0.702710 0.921838 Simple median HF 0.86
835 Body mass index UKB-a:344 Difficulty not smoking for 1 day -0.124350 0.008594 1.912580e-47 -0.141195 -0.107505 FE IVW DF 1.00
2 Body mass index 496 X-11317 -0.228361 0.015830 3.576629e-47 -0.259389 -0.197334 FE IVW DF 1.00
95 Body mass index 835 Body mass index 1.009278 0.023845 6.307733e-47 0.962543 1.056014 Simple mean HF 0.94
95 Body mass index 64 Waist circumference 0.907672 0.063283 1.177729e-46 0.731816 1.083528 FE IVW Tophits 0.79
95 Body mass index 61 Waist circumference 1.030035 0.072326 5.055364e-46 0.888279 1.171791 Weighted median HF 0.92
94 Body mass index 974 Body mass index 0.863309 0.061300 4.802027e-45 0.743164 0.983454 Simple median Tophits 0.94
94 Body mass index 51 Hip circumference 0.900388 0.064256 1.307071e-44 0.768546 1.032230 FE IVW Tophits 0.83
94 Body mass index 63 Waist circumference 0.900388 0.064256 1.307071e-44 0.768546 1.032230 FE IVW Tophits 0.83
94 Body mass index 584 X-12100--hydroxytryptophan* -0.831390 0.059493 2.230265e-44 -0.947997 -0.714783 FE IVW DF 1.00
785 Body mass index 971 Ulcerative colitis -0.015270 0.001104 1.566585e-43 -0.017433 -0.013107 FE IVW DF 1.00
2 Body mass index UKB-a:34 Comparative body size at age 10 0.854604 0.062038 3.575718e-43 0.733013 0.976196 Penalised median Tophits 0.62
785 Body mass index 62 Waist circumference 0.748759 0.054379 3.897897e-43 0.642177 0.855342 FE IVW DF 0.86
2 Body mass index UKB-a:295 Chest pain or discomfort -0.300702 0.021849 4.282196e-43 -0.343527 -0.257877 FE IVW DF 1.00
94 Body mass index 835 Body mass index 1.003683 0.029162 5.254397e-43 0.946526 1.060840 RE IVW HF 0.95
974 Body mass index 91 Obesity class 2 0.269874 0.019773 2.063579e-42 0.231119 0.308629 Penalised median HF 0.84
2 Body mass index 94 Body mass index 0.803025 0.058909 2.599257e-42 0.687565 0.918485 Weighted median Tophits 0.71
94 Body mass index 85 Extreme body mass index 0.228106 0.016796 5.198440e-42 0.191818 0.264395 FE IVW HF 0.72
95 Body mass index 838 Acetoacetate 0.058337 0.004304 7.614172e-42 0.049900 0.066773 FE IVW DF 1.00
835 Body mass index 48 Hip circumference 0.804545 0.059484 1.107733e-41 0.687959 0.921132 Simple median Tophits 0.89
835 Body mass index 61 Waist circumference 0.863855 0.063899 1.206971e-41 0.738615 0.989095 Weighted median DF + HF 0.91
2 Body mass index 85 Extreme body mass index 0.233866 0.017351 2.099127e-41 0.199858 0.267874 Penalised median HF 0.70
95 Body mass index 50 Hip circumference 0.748374 0.055542 2.223629e-41 0.639512 0.857237 FE IVW DF + HF 0.82
95 Body mass index 162 CD32 on 11c+123+DC -0.031138 0.002328 8.481781e-41 -0.035701 -0.026575 FE IVW DF 1.00
94 Body mass index 107 Weight 0.699223 0.052465 1.605826e-40 0.446853 0.951593 FE IVW Tophits 0.66
2 Body mass index UKB-a:33 Breastfed as a baby 0.393931 0.029829 8.081099e-40 0.335466 0.452397 FE IVW DF 1.00
835 Body mass index UKB-a:33 Breastfed as a baby 0.393811 0.029829 8.513273e-40 0.335346 0.452276 FE IVW DF 1.00
94 Body mass index 661 X-12798 0.101398 0.007744 3.610873e-39 0.086219 0.116577 FE IVW DF 1.00
94 Body mass index 469 Alanine -1.297051 0.099765 1.206489e-38 -1.492590 -1.101511 FE IVW DF 1.00
974 Body mass index 85 Extreme body mass index 0.247667 0.019126 2.381271e-38 0.210180 0.285155 Simple median HF 0.68
785 Body mass index 90 Obesity class 1 0.313001 0.024271 4.727540e-38 0.265431 0.360571 Simple median Tophits 0.78
785 Body mass index UKB-a:523 Diagnoses - main ICD10: E03 Other hypothyroidism -8.131670 0.632583 8.093353e-38 -9.371532 -6.891807 FE IVW DF 1.00
974 Body mass index 627 Epiandrosterone sulfate 0.071812 0.005623 2.361307e-37 0.060791 0.082832 FE IVW DF 1.00
2 Body mass index 107 Weight 0.526555 0.041520 7.450627e-37 0.294518 0.758593 FE IVW Tophits 0.68
974 Body mass index UKB-a:452 Medication for pain relief constipation heartburn: Aspirin -1.594824 0.127231 4.808627e-36 -1.844196 -1.345453 FE IVW HF 0.68
94 Body mass index 62 Waist circumference 0.782818 0.062919 1.551503e-35 0.659497 0.906139 FE IVW DF + HF 0.82
785 Body mass index 48 Hip circumference 0.751724 0.060510 1.956696e-35 0.633127 0.870321 Simple median HF 0.89
2 Body mass index 48 Hip circumference 0.751465 0.061157 1.056555e-34 0.631601 0.871330 Weighted median HF 0.89
2 Body mass index 62 Waist circumference 0.930591 0.076387 3.845519e-34 0.780877 1.080306 Penalised median HF 0.78
835 Body mass index UKB-a:287 Arm fat mass (left) 0.675230 0.046123 3.953200e-34 0.584830 0.765629 Simple mode Tophits 0.66
94 Body mass index 91 Obesity class 2 0.270647 0.022286 6.156504e-34 0.226967 0.314326 Penalised median DF + HF 0.76
94 Body mass index UKB-a:58 Cancer code self-reported: malignant melanoma 3.652828 0.301162 7.406363e-34 3.062550 4.243106 FE IVW DF 1.00
835 Body mass index 62 Waist circumference 0.891218 0.074399 4.584212e-33 0.745398 1.037037 Simple median Tophits 0.78
835 Body mass index UKB-a:283 Arm fat mass (right) 0.691107 0.049344 4.592477e-32 0.594395 0.787820 Simple mode Tophits 0.68
94 Body mass index 90 Obesity class 1 0.347826 0.029552 5.586798e-32 0.289904 0.405748 Simple median Tophits 0.83
835 Body mass index 95 Body mass index 0.870877 0.074794 2.472932e-31 0.724283 1.017471 Simple median Tophits 0.70
2 Body mass index 49 Hip circumference 0.702112 0.060544 4.285415e-31 0.583447 0.820777 Weighted median HF 0.79
835 Body mass index 509 X-11423--O-sulfo-L-tyrosine 0.103764 0.009010 1.082916e-30 0.086105 0.121423 FE IVW DF 1.00
2 Body mass index 95 Body mass index 0.861012 0.074801 1.164246e-30 0.714406 1.007618 Penalised median DF + HF 0.71
2 Body mass index UKB-a:283 Arm fat mass (right) 0.686146 0.051584 6.918027e-30 0.585043 0.787248 Simple mode Tophits 0.67
974 Body mass index 751 Palmitoyl sphingomyelin -0.585059 0.051851 1.583370e-29 -0.686687 -0.483431 FE IVW DF 1.00
95 Body mass index UKB-a:283 Arm fat mass (right) 0.580696 0.051604 2.240417e-29 0.479554 0.681838 Penalised median DF 0.58
785 Body mass index 64 Waist circumference 0.946076 0.084641 5.256727e-29 0.780182 1.111970 Penalised median HF 0.81
974 Body mass index UKB-a:163 Treatment/medication code: flecainide -3.526281 0.315634 5.586487e-29 -4.144923 -2.907639 FE IVW DF 1.00
2 Body mass index 638 Asparagine -0.220630 0.019768 6.324446e-29 -0.259375 -0.181885 FE IVW DF 1.00
2 Body mass index 64 Waist circumference 0.829427 0.075626 5.475899e-28 0.681203 0.977651 Weighted median Tophits 0.68
95 Body mass index 49 Hip circumference 0.736293 0.067400 8.829408e-28 0.604192 0.868395 Simple median Tophits 0.86
785 Body mass index 60 Waist circumference 0.986677 0.031547 1.074787e-27 0.924845 1.048509 Simple mean HF 0.90
95 Body mass index 52 Hip circumference 0.576428 0.053160 2.148226e-27 0.343536 0.809321 FE IVW Tophits 0.74
785 Body mass index 558 1-arachidonoylglycerophosphocholine* -0.077362 0.007138 2.259601e-27 -0.091352 -0.063372 FE IVW DF 1.00
835 Body mass index 92 Obesity class 3 0.200948 0.018592 3.150480e-27 0.130202 0.271695 FE IVW DF 1.00
2 Body mass index 835 Body mass index 0.968708 0.006268 7.914895e-27 0.956424 0.980993 RE IVW DF + HF 0.68
974 Body mass index 102 Waist circumference 0.859485 0.080205 8.553527e-27 0.529261 1.189710 FE IVW DF 1.00
95 Body mass index 94 Body mass index 0.828641 0.077830 1.804355e-26 0.676097 0.981184 Weighted median DF + HF 0.80
2 Body mass index UKB-a:287 Arm fat mass (left) 0.663668 0.054742 3.814408e-26 0.556375 0.770961 Simple mode Tophits 0.65
835 Body mass index 51 Hip circumference 0.850901 0.081367 1.351985e-25 0.691426 1.010377 Weighted median DF + HF 0.80
94 Body mass index UKB-a:533 Diagnoses - main ICD10: I21 Acute myocardial infarction -8.510970 0.814480 1.471823e-25 -10.107350 -6.914589 FE IVW DF 1.00
94 Body mass index 52 Hip circumference 0.571534 0.055406 5.998600e-25 0.367343 0.775726 FE IVW DF 0.69
94 Body mass index 60 Waist circumference 0.966572 0.041382 6.345565e-25 0.885464 1.047681 RE IVW HF 0.88
95 Body mass index 60 Waist circumference 1.069912 0.042446 6.723515e-25 0.986718 1.153106 Simple mean HF 0.94
835 Body mass index UKB-a:275 Leg fat mass (right) 0.845767 0.072395 6.821135e-25 0.703875 0.987659 Simple mode DF 0.68
974 Body mass index 92 Obesity class 3 0.196756 0.019381 3.246295e-24 0.140089 0.253423 FE IVW DF 1.00
835 Body mass index UKB-a:279 Leg fat mass (left) 0.865182 0.075977 5.311255e-24 0.716270 1.014094 Simple mode Tophits 0.69
835 Body mass index 63 Waist circumference 0.850901 0.084660 9.106667e-24 0.684972 1.016831 Weighted median DF + HF 0.80
974 Body mass index UKB-a:282 Arm fat percentage (right) 0.962632 0.082854 9.302738e-24 0.800241 1.125023 Penalised mode Tophits 0.67
785 Body mass index 974 Body mass index 0.802167 0.028151 2.783834e-23 0.746990 0.857343 Simple mean HF 0.93
94 Body mass index 162 CD32 on 11c+123+DC -0.059524 0.005989 2.801231e-23 -0.071262 -0.047787 FE IVW DF 1.00
2 Body mass index UKB-a:282 Arm fat percentage (right) 0.837399 0.073223 2.986506e-23 0.693884 0.980913 Simple mode Tophits 0.68
785 Body mass index UKB-a:44 Townsend deprivation index at recruitment -0.542996 0.054701 3.188229e-23 -0.650210 -0.435783 FE IVW DF 1.00
2 Body mass index UKB-a:279 Leg fat mass (left) 0.859073 0.077445 4.302183e-23 0.707284 1.010861 Simple mode Tophits 0.73
94 Body mass index 61 Waist circumference 0.975359 0.042987 6.456803e-23 0.891104 1.059614 Simple mean HF 0.93
94 Body mass index 95 Body mass index 0.689665 0.070189 8.714190e-23 0.485705 0.893626 FE IVW DF 0.73
785 Body mass index 61 Waist circumference 0.935093 0.031319 8.945501e-23 0.873708 0.996478 Simple mean HF 0.92
835 Body mass index UKB-a:282 Arm fat percentage (right) 0.852720 0.075726 9.763353e-23 0.704299 1.001140 Simple mode Tophits 0.73
95 Body mass index UKB-a:260 Tobacco smoking: Ex-smoker 0.881045 0.089778 9.836597e-23 0.705081 1.057009 FE IVW DF 1.00
2 Body mass index 65 Waist circumference 0.926989 0.094652 1.198674e-22 0.741474 1.112503 Weighted median HF 0.77
2 Body mass index UKB-a:248 Body mass index (BMI) 0.709770 0.066082 2.244759e-22 0.580251 0.839288 Simple mode DF 0.65
835 Body mass index UKB-a:185 Treatment/medication code: arcoxia 90mg tablet 8.352394 0.861802 3.267764e-22 6.663263 10.041526 FE IVW DF 1.00
835 Body mass index 627 Epiandrosterone sulfate 0.080427 0.008339 5.149509e-22 0.064084 0.096771 FE IVW DF 1.00
785 Body mass index 94 Body mass index 0.768266 0.079685 5.350304e-22 0.612087 0.924446 Weighted median DF 0.71
2 Body mass index UKB-a:426 Eye problems/disorders: Cataract -0.898863 0.093500 7.010733e-22 -1.082122 -0.715603 FE IVW DF 1.00
2 Body mass index UKB-a:275 Leg fat mass (right) 0.835909 0.078485 9.583195e-22 0.682081 0.989736 Simple mode Tophits 0.72
94 Body mass index UKB-a:33 Breastfed as a baby 0.562825 0.059022 1.486206e-21 0.447142 0.678507 FE IVW DF 1.00
94 Body mass index 349 Heptanoate (7:0) -0.255989 0.026881 1.684168e-21 -0.308676 -0.203301 FE IVW DF 1.00
785 Body mass index 52 Hip circumference 0.509245 0.054493 9.181713e-21 0.402438 0.616052 FE IVW HF 0.74
974 Body mass index UKB-a:564 Diagnoses - main ICD10: M20 Acquired deformities of fingers and toes 1.347046 0.144763 1.337403e-20 1.063311 1.630781 FE IVW DF 1.00
94 Body mass index 49 Hip circumference 0.828059 0.046667 1.455511e-20 0.736593 0.919526 Simple mean HF 0.85
835 Body mass index UKB-a:382 Waist circumference 0.827170 0.078902 2.366097e-20 0.672524 0.981816 Simple mode Tophits 0.65
974 Body mass index 62 Waist circumference 0.910877 0.099020 3.615833e-20 0.716801 1.104952 Simple median DF 0.73
95 Body mass index 785 Body mass index 0.742857 0.080902 4.223257e-20 0.584293 0.901422 Simple median Tophits 0.83
2 Body mass index UKB-a:382 Waist circumference 0.768679 0.074442 6.958562e-20 0.622776 0.914583 Weighted mode Tophits 0.70
94 Body mass index 588 X-12189 0.015877 0.001746 9.444771e-20 0.012456 0.019298 FE IVW DF 1.00
974 Body mass index 965 Lung adenocarcinoma 0.022150 0.002436 9.745648e-20 0.017375 0.026925 FE IVW DF 1.00
94 Body mass index 92 Obesity class 3 0.215161 0.023813 1.631137e-19 0.150749 0.279572 FE IVW DF 1.00
835 Body mass index UKB-a:523 Diagnoses - main ICD10: E03 Other hypothyroidism -11.102661 1.231291 1.931476e-19 -13.515990 -8.689331 FE IVW DF 1.00
974 Body mass index UKB-a:283 Arm fat mass (right) 0.429888 0.048402 6.585004e-19 0.335023 0.524754 Penalised median Tophits 0.61
785 Body mass index UKB-a:163 Treatment/medication code: flecainide -5.073252 0.572362 7.739112e-19 -6.195081 -3.951423 FE IVW DF 1.00
835 Body mass index UKB-a:426 Eye problems/disorders: Cataract -0.884545 0.100135 1.014553e-18 -1.080810 -0.688280 FE IVW DF 1.00
785 Body mass index 49 Hip circumference 0.786373 0.039107 1.417974e-18 0.709724 0.863022 Simple mean HF 0.87
974 Body mass index 48 Hip circumference 0.820383 0.041571 5.756575e-18 0.738905 0.901862 RE IVW HF 0.88
95 Body mass index UKB-a:279 Leg fat mass (left) 0.578516 0.067488 1.016373e-17 0.446241 0.710791 Penalised median DF 0.63
835 Body mass index 50 Hip circumference 0.606618 0.071938 3.382427e-17 0.465623 0.747614 Weighted median HF 0.81
785 Body mass index 106 Weight 0.257602 0.030559 3.469818e-17 0.197705 0.317498 FE IVW DF + HF 0.72
785 Body mass index 85 Extreme body mass index 0.203846 0.024463 7.882323e-17 0.155900 0.251792 Simple median HF 0.64
95 Body mass index UKB-a:34 Comparative body size at age 10 0.913397 0.109793 8.850471e-17 0.698207 1.128587 Penalised median DF 0.66
974 Body mass index UKB-a:373 Ever depressed for a whole week -0.107447 0.012987 1.300000e-16 -0.132901 -0.081993 FE IVW DF 1.00
785 Body mass index UKB-a:287 Arm fat mass (left) 0.719949 0.080786 2.761591e-16 0.561611 0.878288 Weighted mode DF 0.61
785 Body mass index 460 Androsterone sulfate 0.025414 0.003109 2.959852e-16 0.019321 0.031508 FE IVW DF 1.00
2 Body mass index UKB-a:265 Whole body fat mass 0.598325 0.067933 3.561506e-16 0.465178 0.731472 Simple mode Tophits 0.66
835 Body mass index 81 Waist-to-hip ratio -0.233006 0.028609 3.807831e-16 -0.289079 -0.176934 Weighted median DF + HF 0.71
835 Body mass index UKB-a:265 Whole body fat mass 0.605029 0.068774 3.889445e-16 0.470235 0.739824 Simple mode Tophits 0.67
2 Body mass index UKB-a:291 Trunk fat mass 0.586717 0.067353 6.474842e-16 0.454708 0.718727 Simple mode Tophits 0.70
974 Body mass index UKB-a:304 Number of children fathered -0.539847 0.066900 7.059428e-16 -0.670971 -0.408723 FE IVW DF 1.00
95 Body mass index UKB-a:382 Waist circumference 0.525933 0.065273 7.791869e-16 0.398000 0.653866 Penalised median DF 0.62
94 Body mass index 572 Gamma-glutamylphenylalanine 0.326641 0.040555 7.999203e-16 0.247153 0.406130 FE IVW DF 1.00
785 Body mass index UKB-a:464 Vitamin and mineral supplements: Multivitamins +/- minerals -1.693190 0.211915 1.350126e-15 -2.108545 -1.277836 FE IVW DF 1.00
2 Body mass index UKB-a:185 Treatment/medication code: arcoxia 90mg tablet 9.292980 1.172629 2.283064e-15 6.994628 11.591332 FE IVW DF 1.00
785 Body mass index 105 Waist circumference -0.366558 0.046404 2.805688e-15 -0.457510 -0.275606 FE IVW DF 1.00
974 Body mass index 61 Waist circumference 0.833109 0.030054 5.936781e-15 0.774204 0.892014 RE IVW DF + HF 0.88
835 Body mass index 52 Hip circumference 0.358495 0.046159 8.062181e-15 0.229704 0.487286 FE IVW DF + HF 0.82
94 Body mass index 539 ADSGEGDFXAEGGGVR* -0.139473 0.017997 9.199277e-15 -0.174747 -0.104199 FE IVW DF 1.00
94 Body mass index 48 Hip circumference 0.670440 0.051017 1.153650e-14 0.570447 0.770432 RE IVW DF + HF 0.89
95 Body mass index 90 Obesity class 1 0.377866 0.012269 2.902962e-14 0.353819 0.401914 RE IVW HF 0.88
785 Body mass index 331 Stearate (18:0) 0.129227 0.017010 3.025379e-14 0.095888 0.162566 FE IVW DF 1.00
835 Body mass index UKB-a:291 Trunk fat mass 0.593631 0.073137 3.072501e-14 0.450284 0.736978 Simple mode Tophits 0.69
835 Body mass index 100 Hip circumference 0.133639 0.017794 5.905814e-14 0.098762 0.168516 FE IVW DF 1.00
785 Body mass index UKB-a:282 Arm fat percentage (right) 0.988532 0.121996 6.512575e-14 0.749424 1.227639 Penalised mode Tophits 0.60
2 Body mass index UKB-a:124 Treatment/medication code: becotide 50 inhaler -4.991635 0.666626 6.997612e-14 -6.298221 -3.685049 FE IVW DF 1.00
95 Body mass index 417 Myo-inositol 0.924195 0.123818 8.383258e-14 0.681512 1.166877 FE IVW DF 1.00
2 Body mass index 61 Waist circumference 0.852659 0.026527 8.955366e-14 0.800667 0.904651 Simple mean DF + HF 0.87
2 Body mass index 52 Hip circumference 0.393972 0.053571 1.921351e-13 0.256117 0.531827 FE IVW DF + HF 0.78
785 Body mass index UKB-a:157 Treatment/medication code: liothyronine 8.168663 1.110844 1.929930e-13 5.991408 10.345918 FE IVW DF 1.00
785 Body mass index 77 Waist-to-hip ratio 0.568235 0.077507 2.277239e-13 0.301703 0.834768 FE IVW DF 1.00
2 Body mass index 627 Epiandrosterone sulfate 0.076208 0.010434 2.790656e-13 0.055758 0.096657 FE IVW DF 1.00
2 Body mass index 100 Hip circumference 0.129566 0.017747 2.864881e-13 0.094781 0.164351 FE IVW DF 1.00
2 Body mass index 77 Waist-to-hip ratio 0.409296 0.056158 3.139445e-13 0.150685 0.667907 FE IVW DF 1.00
95 Body mass index 900 Free cholesterol in medium HDL -0.083577 0.011475 3.250220e-13 -0.106067 -0.061087 FE IVW DF 1.00
94 Body mass index 50 Hip circumference 0.590453 0.081087 3.296772e-13 0.431524 0.749381 Penalised median HF 0.74
785 Body mass index 76 Waist-to-hip ratio 0.588018 0.080840 3.494477e-13 0.311502 0.864533 FE IVW DF 1.00
95 Body mass index UKB-a:102 Non-cancer illness code self-reported: diverticular disease/diverticulitis 1.007553 0.138982 4.182036e-13 0.735149 1.279957 FE IVW DF 1.00
974 Body mass index UKB-a:279 Leg fat mass (left) 0.945427 0.122758 4.292818e-13 0.704825 1.186029 Penalised mode Tophits 0.67
835 Body mass index UKB-a:144 Treatment/medication code: rhinocort 50micrograms nasal spray 5.483659 0.757051 4.374146e-13 3.999839 6.967479 FE IVW DF 1.00
2 Body mass index 76 Waist-to-hip ratio 0.424208 0.058579 4.433996e-13 0.156213 0.692204 FE IVW DF 1.00
2 Body mass index UKB-a:286 Arm fat percentage (left) 0.805668 0.104481 5.840801e-13 0.600890 1.010446 Simple mode DF 0.70
95 Body mass index UKB-a:287 Arm fat mass (left) 0.735344 0.095595 8.322863e-13 0.547981 0.922708 Weighted mode DF 0.59
974 Body mass index UKB-a:523 Diagnoses - main ICD10: E03 Other hypothyroidism -13.161128 1.847652 1.054765e-12 -16.782525 -9.539730 FE IVW DF 1.00
835 Body mass index UKB-a:286 Arm fat percentage (left) 0.804429 0.105844 1.138672e-12 0.596978 1.011880 Simple mode DF 0.71
974 Body mass index 52 Hip circumference 0.567311 0.080592 1.931942e-12 0.409354 0.725268 Weighted median HF 0.65
785 Body mass index 543 X-11793--oxidized bilirubin* 0.048834 0.006949 2.107883e-12 0.035214 0.062455 FE IVW DF 1.00
974 Body mass index UKB-a:382 Waist circumference 0.796354 0.106395 3.181022e-12 0.587823 1.004885 Penalised mode Tophits 0.62
835 Body mass index 76 Waist-to-hip ratio 0.420080 0.060394 3.510264e-12 0.171819 0.668341 FE IVW DF 1.00
835 Body mass index UKB-a:248 Body mass index (BMI) -0.694099 0.095747 4.991444e-12 -0.881760 -0.506439 Weighted mode Tophits 0.66
974 Body mass index UKB-a:275 Leg fat mass (right) 0.888052 0.122341 6.354069e-12 0.648268 1.127836 Penalised mode Tophits 0.69
785 Body mass index UKB-a:283 Arm fat mass (right) 0.683300 0.093762 8.859133e-12 0.499530 0.867070 Weighted mode DF 0.57
785 Body mass index UKB-a:152 Treatment/medication code: eumovate cream -1.232349 0.180946 9.719571e-12 -1.587003 -0.877695 FE IVW DF 1.00
974 Body mass index UKB-a:291 Trunk fat mass 0.291783 0.042969 1.116904e-11 0.207565 0.376000 Simple median DF 0.63
835 Body mass index UKB-a:124 Treatment/medication code: becotide 50 inhaler -4.990300 0.743319 1.899597e-11 -6.447205 -3.533395 FE IVW DF 1.00
94 Body mass index 64 Waist circumference 1.059718 0.051028 2.360414e-11 0.959704 1.159732 RE IVW HF 0.84
94 Body mass index 65 Waist circumference 1.067511 0.046006 2.445470e-11 0.977339 1.157683 Simple mean HF 0.81
95 Body mass index 1017 Immunoglobulin G index levels -0.006094 0.000927 4.863336e-11 -0.007911 -0.004278 FE IVW DF 1.00
835 Body mass index UKB-a:44 Townsend deprivation index at recruitment -0.411503 0.063013 6.555697e-11 -0.535008 -0.287998 FE IVW DF 1.00
835 Body mass index UKB-a:249 Weight 0.654474 0.097365 1.138001e-10 0.463642 0.845306 Simple mode Tophits 0.63
974 Body mass index UKB-a:203 Illnesses of father: None of the above (group 2) 0.444511 0.069200 1.330967e-10 0.308879 0.580142 FE IVW DF 1.00
95 Body mass index 793 Urate 0.007477 0.001166 1.446857e-10 0.005191 0.009763 FE IVW DF 1.00
95 Body mass index UKB-a:524 Diagnoses - main ICD10: E04 Other non-toxic goitre 5.026592 0.786659 1.661078e-10 3.484740 6.568444 FE IVW DF 1.00
974 Body mass index UKB-a:265 Whole body fat mass 0.664224 0.099444 1.872351e-10 0.469317 0.859131 Penalised mode Tophits 0.65
785 Body mass index 446 Indoleacetate -0.517403 0.081364 2.029293e-10 -0.676877 -0.357930 FE IVW DF 1.00
95 Body mass index UKB-a:286 Arm fat percentage (left) 0.487486 0.076742 2.122102e-10 0.337073 0.637898 Penalised median DF + HF 0.65
94 Body mass index 720 X-14205--alpha-glutamyltyrosine 0.303224 0.047952 2.557470e-10 0.209238 0.397210 FE IVW DF 1.00
785 Body mass index 469 Alanine -1.135852 0.179850 2.691933e-10 -1.488358 -0.783346 FE IVW DF 1.00
2 Body mass index 87 Extreme waist-to-hip ratio -0.022227 0.003542 3.489445e-10 -0.029169 -0.015284 FE IVW DF 1.00
94 Body mass index 446 Indoleacetate -0.979489 0.156186 3.580627e-10 -1.285614 -0.673364 FE IVW DF 1.00
835 Body mass index 751 Palmitoyl sphingomyelin -0.395620 0.063113 3.646802e-10 -0.519322 -0.271919 FE IVW DF 1.00
95 Body mass index UKB-a:264 Body fat percentage 0.438811 0.070486 4.799865e-10 0.300661 0.576961 Penalised median DF + HF 0.61
785 Body mass index 27 Birth weight 0.184135 0.029753 6.062301e-10 0.125819 0.242451 FE IVW DF 1.00
835 Body mass index UKB-a:115 Non-cancer illness code self-reported: vitiligo 13.500070 2.188100 6.839023e-10 9.211394 17.788746 FE IVW DF 1.00
785 Body mass index 107 Weight 0.511429 0.083308 8.303193e-10 0.348149 0.674710 Weighted median HF 0.66
95 Body mass index 53 Hip circumference 0.459723 0.075210 9.806141e-10 0.281269 0.638177 FE IVW HF 0.67
785 Body mass index 1005 Percent emphysema 0.058154 0.009580 1.276472e-09 0.039377 0.076930 FE IVW DF 1.00
2 Body mass index UKB-a:44 Townsend deprivation index at recruitment -0.390768 0.064439 1.326722e-09 -0.517068 -0.264467 FE IVW DF 1.00
94 Body mass index 93 Overweight 0.576460 0.027644 1.426087e-09 0.522278 0.630642 Simple mean HF 0.80
835 Body mass index UKB-a:264 Body fat percentage 0.689867 0.109133 1.603721e-09 0.475971 0.903763 Simple mode Tophits 0.67
94 Body mass index 53 Hip circumference 0.440026 0.072946 1.616922e-09 0.283773 0.596278 FE IVW HF 0.67
974 Body mass index UKB-a:485 Types of physical activity in last 4 weeks: Strenuous sports -2.026974 0.336826 1.767351e-09 -2.687153 -1.366794 FE IVW DF 1.00
785 Body mass index UKB-a:328 Number of cigarettes previously smoked daily 0.157891 0.026246 1.790673e-09 0.106448 0.209333 FE IVW DF 1.00
785 Body mass index UKB-a:279 Leg fat mass (left) 0.846986 0.134224 1.818242e-09 0.583912 1.110061 Weighted mode DF 0.62
2 Body mass index UKB-a:249 Weight 0.660285 0.105890 1.837915e-09 0.452745 0.867824 Simple mode DF 0.69
94 Body mass index 1051 Transferrin Saturation -0.028542 0.004760 2.014011e-09 -0.037871 -0.019213 FE IVW DF 1.00
95 Body mass index 91 Obesity class 2 0.279100 0.012222 2.810549e-09 0.255146 0.303055 Simple mean HF 0.77
2 Body mass index 498 X-11327 -0.411327 0.069753 3.704558e-09 -0.548044 -0.274610 FE IVW DF 1.00
835 Body mass index 1147 Eicosapentaenoic acid (20:5n3) -0.019446 0.003320 4.729468e-09 -0.025954 -0.012938 FE IVW DF 1.00
785 Body mass index UKB-a:275 Leg fat mass (right) 0.744252 0.122409 5.593776e-09 0.504335 0.984169 Simple mode DF 0.63
2 Body mass index 999 Body fat 0.382115 0.066341 8.417322e-09 0.252089 0.512140 Weighted median DF + HF 0.69
785 Body mass index UKB-a:264 Body fat percentage 0.334606 0.058101 8.458259e-09 0.220731 0.448482 Penalised median Tophits 0.60
974 Body mass index 638 Asparagine -0.309086 0.053737 8.828809e-09 -0.414410 -0.203761 FE IVW DF 1.00
785 Body mass index 892 Triglycerides in large VLDL -0.116351 0.020352 1.084921e-08 -0.156241 -0.076461 FE Egger HF 0.64
95 Body mass index UKB-a:445 Blood clot DVT bronchitis emphysema asthma rhinitis eczema allergy diagnosed by doctor: Blood clot in the lung 2.089873 0.365613 1.090092e-08 1.373272 2.806474 FE IVW DF 1.00
2 Body mass index UKB-a:210 Illnesses of mother: Alzheimer's disease/dementia -0.674114 0.118385 1.239013e-08 -1.209427 -0.138801 FE IVW DF 1.00
835 Body mass index 339 4-acetamidobutanoate -0.190286 0.033547 1.409690e-08 -0.256038 -0.124534 FE IVW DF 1.00
974 Body mass index 64 Waist circumference 0.918629 0.056519 1.613196e-08 0.807851 1.029407 RE IVW HF 0.75
785 Body mass index 693 X-13548 -0.291786 0.051887 1.871485e-08 -0.393485 -0.190088 FE IVW DF 1.00
785 Body mass index UKB-a:309 Other serious medical condition/disability diagnosed by doctor 0.463776 0.083262 2.546404e-08 0.300582 0.626970 FE IVW DF 1.00
2 Body mass index 803 PGC cross-disorder traits -0.138482 0.024898 2.668182e-08 -0.222171 -0.054793 FE IVW DF 1.00
94 Body mass index 999 Body fat 0.290834 0.052335 2.742180e-08 0.188257 0.393411 FE IVW DF + HF 0.69
2 Body mass index 509 X-11423--O-sulfo-L-tyrosine 0.093998 0.016941 2.880484e-08 0.060793 0.127202 FE IVW DF 1.00
94 Body mass index 100 Hip circumference 0.210946 0.038257 3.509902e-08 0.135962 0.285930 FE IVW DF 1.00
974 Body mass index UKB-a:173 Treatment/medication code: co-amilofruse 5.867223 1.069632 4.128299e-08 3.770745 7.963701 FE IVW DF 1.00
835 Body mass index UKB-a:210 Illnesses of mother: Alzheimer's disease/dementia -0.678576 0.123761 4.183052e-08 -1.224810 -0.132341 FE IVW DF 1.00
785 Body mass index UKB-a:200 Suffer from 'nerves' 2.252650 0.412064 4.583820e-08 1.169844 3.335455 FE IVW HF 0.65
94 Body mass index 449 N-acetylglycine 0.202871 0.037203 4.949689e-08 0.129954 0.275789 FE IVW DF 1.00
785 Body mass index UKB-a:290 Trunk fat percentage 0.172773 0.031701 5.035919e-08 0.108449 0.237097 FE IVW HF 0.68
785 Body mass index UKB-a:249 Weight 0.394327 0.070168 5.166431e-08 0.256801 0.531853 Weighted mode DF 0.64
974 Body mass index UKB-a:290 Trunk fat percentage 0.281525 0.051716 5.220738e-08 0.180162 0.382887 Simple median DF 0.59
785 Body mass index 560 X-11905 -0.008019 0.001475 5.371199e-08 -0.010909 -0.005129 FE IVW DF 1.00
785 Body mass index UKB-a:344 Difficulty not smoking for 1 day -0.169152 0.031200 5.911999e-08 -0.230305 -0.107999 FE IVW DF 1.00
94 Body mass index 331 Stearate (18:0) 0.430550 0.079883 7.054244e-08 0.273980 0.587120 FE IVW DF 1.00
2 Body mass index 105 Waist circumference -0.301818 0.056080 7.368034e-08 -0.461392 -0.142243 FE IVW DF 1.00
974 Body mass index 902 Concentration of medium HDL particles 0.046923 0.008736 7.816738e-08 0.029800 0.064045 FE IVW DF 1.00
2 Body mass index UKB-a:75 Non-cancer illness code self-reported: type 2 diabetes 8.237114 1.539291 8.735458e-08 -2.195929 18.670157 FE IVW DF 1.00
835 Body mass index 803 PGC cross-disorder traits -0.137812 0.025776 8.966433e-08 -0.221629 -0.053995 FE IVW DF 1.00
2 Body mass index UKB-a:115 Non-cancer illness code self-reported: vitiligo 14.549451 2.732679 1.013730e-07 9.193401 19.905501 FE IVW DF 1.00
94 Body mass index 685 X-13435 0.188811 0.035598 1.133118e-07 0.119039 0.258584 FE IVW DF 1.00
94 Body mass index UKB-a:328 Number of cigarettes previously smoked daily 0.151803 0.028621 1.133151e-07 0.095707 0.207900 FE IVW DF 1.00
835 Body mass index 761 Corrected insulin response 0.047311 0.008934 1.187882e-07 0.029799 0.064822 FE IVW DF 1.00
835 Body mass index UKB-a:290 Trunk fat percentage 0.575725 0.105022 1.348976e-07 0.369886 0.781564 Simple mode Tophits 0.70
2 Body mass index 761 Corrected insulin response 0.049081 0.009331 1.442307e-07 0.030791 0.067370 FE IVW DF 1.00
94 Body mass index 920 Pyruvate -0.195028 0.037189 1.568821e-07 -0.267917 -0.122138 FE IVW DF 1.00
835 Body mass index 87 Extreme waist-to-hip ratio -0.020790 0.003966 1.592376e-07 -0.028564 -0.013016 FE IVW DF 1.00
835 Body mass index UKB-a:75 Non-cancer illness code self-reported: type 2 diabetes 8.255940 1.578122 1.681430e-07 -1.995881 18.507760 FE IVW DF 1.00
785 Body mass index 51 Hip circumference 0.763073 0.053313 1.693734e-07 0.658580 0.867566 Simple mean DF + HF 0.82
785 Body mass index 63 Waist circumference 0.763073 0.053313 1.693734e-07 0.658580 0.867566 Simple mean DF + HF 0.82
974 Body mass index 836 College completion -0.130559 0.024966 1.699348e-07 -0.179492 -0.081626 FE IVW DF 1.00
974 Body mass index 568 X-12040 -0.010655 0.002039 1.737183e-07 -0.014651 -0.006658 FE IVW DF 1.00
2 Body mass index UKB-a:98 Non-cancer illness code self-reported: hypopituitarism -0.656227 0.125608 1.747315e-07 -0.902419 -0.410035 FE IVW DF 1.00
2 Body mass index UKB-a:274 Leg fat percentage (right) 0.856586 0.158431 1.753503e-07 0.546068 1.167105 Simple mode Tophits 0.67
835 Body mass index 105 Waist circumference -0.300592 0.057599 1.802136e-07 -0.454176 -0.147008 FE IVW DF 1.00
2 Body mass index UKB-a:264 Body fat percentage 0.674663 0.125274 2.075758e-07 0.429131 0.920196 Simple mode DF 0.68
835 Body mass index UKB-a:274 Leg fat percentage (right) 0.874970 0.162913 2.098564e-07 0.555666 1.194274 Simple mode Tophits 0.68
785 Body mass index UKB-a:265 Whole body fat mass 0.588086 0.110232 2.317264e-07 0.372035 0.804138 Penalised mode Tophits 0.64
94 Body mass index 355 Proline 0.072725 0.014096 2.480188e-07 0.045097 0.100354 FE IVW DF 1.00
974 Body mass index UKB-a:210 Illnesses of mother: Alzheimer's disease/dementia -0.815706 0.159204 2.997016e-07 -1.429633 -0.201778 FE IVW DF 1.00
2 Body mass index 27 Birth weight 0.159156 0.031151 3.236248e-07 0.094816 0.223497 FE IVW DF 1.00
785 Body mass index UKB-a:514 Frequency of stair climbing in last 4 weeks -0.360958 0.071448 4.371587e-07 -0.500997 -0.220920 FE IVW DF 1.00
2 Body mass index 762 Corrected insulin response 0.039759 0.007888 4.636575e-07 0.024300 0.055219 FE IVW DF 1.00
835 Body mass index 762 Corrected insulin response 0.038504 0.007647 4.771795e-07 0.023516 0.053491 FE IVW DF 1.00
94 Body mass index UKB-a:181 Treatment/medication code: indivina 1mg/2.5mg tablet 12.771320 2.555824 5.824454e-07 7.761905 17.780734 FE IVW DF 1.00
835 Body mass index 999 Body fat 0.420896 0.084263 5.882058e-07 0.255744 0.586047 Simple median Tophits 0.68
2 Body mass index UKB-a:290 Trunk fat percentage 0.562214 0.108818 6.082098e-07 0.348935 0.775494 Simple mode Tophits 0.69
974 Body mass index 762 Corrected insulin response 0.051837 0.010449 7.020352e-07 0.031356 0.072317 FE IVW DF 1.00
95 Body mass index UKB-a:217 Illnesses of siblings: Heart disease 1.363519 0.274949 7.079725e-07 0.824618 1.902419 FE IVW DF 1.00
974 Body mass index 53 Hip circumference 0.474279 0.095674 7.150177e-07 0.286761 0.661796 Weighted median HF 0.62
785 Body mass index UKB-a:280 Leg fat-free mass (left) 0.242159 0.048874 7.242514e-07 0.146367 0.337950 Weighted median DF 0.66
95 Body mass index UKB-a:209 Illnesses of mother: Heart disease -2.028895 0.410570 7.746290e-07 -2.833612 -1.224177 FE IVW DF 1.00
95 Body mass index UKB-a:278 Leg fat percentage (left) 0.451195 0.091384 7.918719e-07 0.272086 0.630304 Penalised median DF + HF 0.64
974 Body mass index UKB-a:344 Difficulty not smoking for 1 day -0.088006 0.017928 9.160109e-07 -0.123144 -0.052867 FE IVW DF 1.00
2 Body mass index 51 Hip circumference 0.816935 0.051262 9.296272e-07 0.716460 0.917409 Simple mean DF + HF 0.78
2 Body mass index 63 Waist circumference 0.816935 0.051262 9.296272e-07 0.716460 0.917409 Simple mean DF + HF 0.78
785 Body mass index 100 Hip circumference 0.132446 0.027260 1.182645e-06 0.079015 0.185876 FE IVW DF 1.00
974 Body mass index 901 Total lipids in medium HDL 0.043756 0.009008 1.189295e-06 0.026100 0.061412 FE IVW DF 1.00
835 Body mass index UKB-a:388 Hip circumference 0.592749 0.118682 1.235309e-06 0.360137 0.825361 Simple mode DF 0.67
785 Body mass index UKB-a:281 Leg predicted mass (left) 0.243702 0.050250 1.235808e-06 0.145214 0.342190 Weighted median DF 0.66
785 Body mass index UKB-a:539 Diagnoses - main ICD10: I84 Haemorrhoids -0.837885 0.173005 1.278157e-06 -1.176976 -0.498795 FE IVW DF 1.00
94 Body mass index 105 Waist circumference -0.297607 0.061553 1.331893e-06 -0.418252 -0.176962 FE IVW DF 1.00
95 Body mass index 1158 Stearic acid (18:0) plasma levels -0.004650 0.000962 1.357647e-06 -0.006536 -0.002763 FE IVW DF 1.00
2 Body mass index 675 X-13215 -0.197164 0.040835 1.377039e-06 -0.277201 -0.117127 FE IVW DF 1.00
2 Body mass index UKB-a:197 Prospective memory result -1.128181 0.234399 1.486250e-06 -2.751745 0.495383 FE IVW DF 1.00
94 Body mass index UKB-a:119 Treatment/medication code: isosorbide dinitrate -5.402511 1.125765 1.594843e-06 -7.609010 -3.196012 FE IVW DF 1.00
95 Body mass index 761 Corrected insulin response 0.069723 0.014609 1.819949e-06 0.041088 0.098357 FE IVW DF 1.00
785 Body mass index 50 Hip circumference 0.495339 0.058275 2.010320e-06 0.381121 0.609557 RE IVW DF + HF 0.82
835 Body mass index 69 Waist circumference -0.215090 0.033329 2.143223e-06 -0.280415 -0.149764 RE IVW DF 0.73
95 Body mass index UKB-a:282 Arm fat percentage (right) 0.381502 0.080513 2.154092e-06 0.223700 0.539304 Penalised median HF 0.64
785 Body mass index UKB-a:343 Time from waking to first cigarette 0.140729 0.029723 2.193568e-06 0.082473 0.198986 FE IVW DF 1.00
835 Body mass index 27 Birth weight 0.151041 0.031947 2.268156e-06 0.088426 0.213656 FE IVW DF 1.00
95 Body mass index 331 Stearate (18:0) -0.694808 0.147119 2.326656e-06 -0.983161 -0.406454 FE IVW DF 1.00
785 Body mass index UKB-a:268 Basal metabolic rate 0.366422 0.076463 2.694188e-06 0.216558 0.516286 Weighted mode DF 0.64
974 Body mass index 935 Sphingomyelins -0.048764 0.010401 2.755292e-06 -0.069150 -0.028377 FE IVW DF 1.00
835 Body mass index UKB-a:197 Prospective memory result -1.113448 0.237750 2.823422e-06 -2.802945 0.576048 FE IVW DF 1.00
95 Body mass index UKB-a:564 Diagnoses - main ICD10: M20 Acquired deformities of fingers and toes 3.304213 0.706751 2.936438e-06 1.918981 4.689444 FE IVW DF 1.00
974 Body mass index 111 Waist-to-hip ratio -0.199682 0.042801 3.081226e-06 -0.283571 -0.115793 Simple median HF 0.76
95 Body mass index 999 Body fat 0.540801 0.116430 3.403356e-06 0.312602 0.769000 Penalised median DF + HF 0.68
95 Body mass index UKB-a:388 Hip circumference 0.238158 0.051626 3.965896e-06 0.136973 0.339343 Penalised median DF + HF 0.64
2 Body mass index 1147 Eicosapentaenoic acid (20:5n3) -0.020470 0.004446 4.138219e-06 -0.029184 -0.011756 FE IVW DF 1.00
94 Body mass index UKB-a:148 Treatment/medication code: bisoprolol 4.124541 0.899396 4.520331e-06 2.361725 5.887358 FE IVW DF 1.00
94 Body mass index 360 Gamma-glutamyltyrosine 0.722956 0.158775 5.280171e-06 0.411757 1.034155 FE IVW DF 1.00
974 Body mass index 419 1,5-anhydroglucitol (1,5-AG) 0.328988 0.072344 5.427736e-06 0.187194 0.470783 FE IVW DF 1.00
95 Body mass index UKB-a:98 Non-cancer illness code self-reported: hypopituitarism -10.975775 2.428790 6.212368e-06 -15.736204 -6.215346 FE IVW DF 1.00
2 Body mass index UKB-a:388 Hip circumference 0.582301 0.125984 6.474780e-06 0.335376 0.829226 Simple mode Tophits 0.68
94 Body mass index 693 X-13548 -0.793880 0.176271 6.676939e-06 -1.139371 -0.448388 FE IVW DF 1.00
974 Body mass index 94 Body mass index 0.785595 0.055724 7.951599e-06 0.676376 0.894815 Simple mean DF + HF 0.78
785 Body mass index UKB-a:41 Father's age at death -0.561316 0.125820 8.148469e-06 -0.807924 -0.314708 FE IVW DF 1.00
95 Body mass index 65 Waist circumference 0.714767 0.072333 9.276447e-06 0.572995 0.856539 RE IVW DF + HF 0.80
785 Body mass index 661 X-12798 0.044855 0.010125 9.424843e-06 0.025009 0.064700 FE IVW DF 1.00
MATCH (t1:Gwas)-[r:MR]->(t2:Gwas) WHERE t2.trait = "Body mass index" AND r.p < 1e-05 RETURN t1.id AS exposure_id, t1.trait AS exposure_name, t2.id AS outcome_id, t2.trait AS outcome_name, r.estimate AS estimate, r.se AS se, r.p AS p, r.ci_upp as ci_upp, r.ci_low AS ci_low, r.selection AS selection, r.method AS method, r.moescore AS moescore ORDER BY r.p ;
curl -X 'GET' -H 'Accept: */*' -H 'Accept-Encoding: gzip, deflate' -H 'Connection: keep-alive' -H 'User-Agent: python-requests/2.22.0' 'http://api.epigraphdb.org_private/mr?outcome=Body+mass+index&pval_threshold=1e-05'