MR causal estimate

Pre-computed Mendelian randomization results

 

Exposure trait

 

P-value threshold: 1e-5
   
Outcome trait

 

P-value threshold: 1e-5
   
Exposure trait
Outcome trait

 

P-value threshold: 1e-5
   

 

 

Summary

This view provides automated causal estimates between pairs of traits using the results from MR-EvE (Hemani et al, bioRxiv 10.1101/173682). Note that these are preliminary results generated using an automated algorithm, so should always be validated by performing an analysis with MR-Base.

Three views are available:

  • Searching for anything that an exposure might cause
  • Searching for anything that might cause an outcome
  • Retrieving the causal estimate between a single exposure and outcome

The Query tab shows how this query works and provides the API call to replicate this programmatically.

Data sources

  • MR-EvE (Hemani et al, Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome, bioRxiv 10.1101/173682)

How to use

All three approaches comprise a search form in which you enter trait values and select a threshold. After clicking search you can view the top results in the Network plot tab or the full set of results in the Table tab. The Query tab provides the information you need to download the data using the API.

The three views are accessed by pressing one of the three buttons: Search exposure trait, Search outcome trait or Search exposure and outcome traits.

Once you have selected a view, enter the trait name(s), select a p-value threshold, then click Search.

View the top results in the Network plot tab, access and search the full results in the Table tab, or use the Query tab to find out how to download data using the API.

Changing the threshold: If you move the slider you will need to click Search again to apply the new threshold

Examples

The following examples illustrate the three types of search:

 Displays the top 50 relationships

 

outcome_id outcome_name exposure_id exposure_name estimate se p ci_low ci_upp method selection moescore
UKB-a:282 Arm fat percentage (right) 2 Body mass index 0.525751 0.012324 0.000000e+00 0.501597 0.549906 FE IVW DF + HF 0.94
48 Hip circumference 2 Body mass index 0.828392 0.014869 0.000000e+00 0.799249 0.857535 FE IVW Tophits 0.91
65 Waist circumference 2 Body mass index 0.778973 0.019106 0.000000e+00 0.741526 0.816420 FE IVW DF + HF 0.88
85 Extreme body mass index 2 Body mass index 3.818299 0.091106 0.000000e+00 3.639731 3.996866 FE IVW HF 0.79
93 Overweight 835 Body mass index 1.671103 0.034076 0.000000e+00 1.604314 1.737891 FE IVW Tophits 0.84
60 Waist circumference 835 Body mass index 0.819575 0.019484 0.000000e+00 0.781387 0.857763 FE IVW Tophits 0.90
61 Waist circumference 835 Body mass index 0.823566 0.019441 0.000000e+00 0.785461 0.861671 FE IVW Tophits 0.94
64 Waist circumference 835 Body mass index 0.782721 0.019255 0.000000e+00 0.744980 0.820461 FE IVW DF + HF 0.89
1017 Immunoglobulin G index levels 94 Body mass index -101.187348 1.370493 0.000000e+00 -103.873513 -98.501183 FE IVW DF 1.00
50 Hip circumference 835 Body mass index 0.836276 0.022981 6.196356e-290 0.791233 0.881319 FE IVW HF 0.89
974 Body mass index 95 Body mass index 0.980908 0.027925 2.639583e-270 0.926176 1.035641 FE IVW HF 0.74
UKB-a:248 Body mass index (BMI) 785 Body mass index 0.810138 0.023880 2.819634e-252 0.728721 0.891556 FE IVW Tophits 0.87
52 Hip circumference 2 Body mass index 0.797229 0.023501 3.073123e-252 0.751166 0.843291 FE IVW Tophits 0.85
53 Hip circumference 2 Body mass index 0.810898 0.024144 2.645083e-247 0.763576 0.858219 FE IVW Tophits 0.85
52 Hip circumference 785 Body mass index 0.777493 0.023170 7.391738e-247 0.732079 0.822906 FE IVW DF + HF 0.92
UKB-a:286 Arm fat percentage (left) 974 Body mass index 0.507870 0.015141 1.169561e-246 0.478193 0.537547 FE IVW HF 0.88
UKB-a:277 Leg predicted mass (right) 2 Body mass index 0.426755 0.013009 4.957147e-236 0.401258 0.452252 FE IVW DF + HF 0.91
UKB-a:282 Arm fat percentage (right) 974 Body mass index 0.497229 0.015474 1.479457e-226 0.466901 0.527558 FE IVW HF 0.88
UKB-a:290 Trunk fat percentage 835 Body mass index 0.526828 0.017116 4.910595e-208 0.488020 0.565636 FE IVW DF + HF 0.92
94 Body mass index 2 Body mass index 0.857565 0.027974 2.188032e-206 0.802737 0.912394 FE IVW DF + HF 0.92
UKB-a:283 Arm fat mass (right) 2 Body mass index 0.807171 0.026565 8.801050e-203 0.755104 0.859238 Simple median Tophits 0.94
UKB-a:267 Whole body water mass 835 Body mass index 0.377597 0.012440 2.292537e-202 0.351368 0.403827 FE IVW DF + HF 0.93
UKB-a:388 Hip circumference 785 Body mass index 0.667274 0.022028 1.427638e-201 0.592914 0.741634 FE IVW Tophits 0.91
UKB-a:266 Whole body fat-free mass 835 Body mass index 0.373149 0.012459 4.321901e-197 0.347044 0.399254 FE IVW DF + HF 0.93
UKB-a:248 Body mass index (BMI) 2 Body mass index 0.841603 0.028229 2.595856e-195 0.786275 0.896930 Simple median HF 0.92
UKB-a:275 Leg fat mass (right) 2 Body mass index 0.640040 0.021792 1.300651e-189 0.597329 0.682751 Weighted median HF 0.93
64 Waist circumference 785 Body mass index 0.789841 0.026976 1.873285e-188 0.736969 0.842713 FE IVW DF + HF 0.86
UKB-a:287 Arm fat mass (left) 2 Body mass index 0.793330 0.027190 3.815672e-187 0.740038 0.846622 Simple median Tophits 0.93
UKB-a:268 Basal metabolic rate 785 Body mass index 0.391998 0.013567 1.404866e-183 0.316348 0.467649 FE IVW Tophits 0.68
103 Waist circumference 835 Body mass index 0.812723 0.028139 2.002828e-183 0.757570 0.867876 FE IVW HF 0.90
107 Weight 835 Body mass index 0.947670 0.033001 2.385730e-181 0.882988 1.012352 FE IVW HF 0.92
UKB-a:248 Body mass index (BMI) 835 Body mass index 0.847892 0.030574 2.844568e-169 0.787968 0.907816 Weighted median HF 0.87
UKB-a:388 Hip circumference 2 Body mass index 0.724105 0.026588 2.563413e-163 0.671993 0.776216 Simple median Tophits 0.95
UKB-a:249 Weight 2 Body mass index 0.714833 0.026381 1.070859e-161 0.663127 0.766538 Simple median Tophits 0.93
UKB-a:382 Waist circumference 2 Body mass index 0.656440 0.024496 3.385451e-158 0.608430 0.704451 Simple median Tophits 0.94
UKB-a:288 Arm fat-free mass (left) 785 Body mass index 0.332647 0.012604 1.638956e-153 0.253177 0.412117 FE IVW Tophits 0.72
UKB-a:291 Trunk fat mass 2 Body mass index 0.737300 0.027998 7.760372e-153 0.682426 0.792174 Simple median Tophits 0.93
UKB-a:286 Arm fat percentage (left) 2 Body mass index 0.545028 0.020765 7.635751e-152 0.504329 0.585726 Simple median Tophits 0.95
UKB-a:275 Leg fat mass (right) 835 Body mass index 0.622749 0.023780 3.642129e-151 0.576141 0.669357 Weighted median HF 0.93
UKB-a:287 Arm fat mass (left) 835 Body mass index 0.767435 0.029526 6.126063e-149 0.709565 0.825305 Weighted median HF 0.95
UKB-a:279 Leg fat mass (left) 835 Body mass index 0.613473 0.023608 7.187158e-149 0.567202 0.659744 Simple median Tophits 0.91
UKB-a:278 Leg fat percentage (left) 2 Body mass index 0.409530 0.015760 7.376177e-149 0.378640 0.440420 Simple median Tophits 0.92
UKB-a:382 Waist circumference 835 Body mass index 0.635526 0.024646 1.259519e-146 0.587221 0.683831 Weighted median HF 0.95
UKB-a:283 Arm fat mass (right) 835 Body mass index 0.785773 0.030962 4.334952e-142 0.725089 0.846457 Simple median Tophits 0.96
90 Obesity class 1 785 Body mass index 1.954012 0.077311 6.041506e-141 1.802483 2.105541 FE IVW DF + HF 0.89
UKB-a:265 Whole body fat mass 835 Body mass index 0.754599 0.030225 1.437971e-137 0.695359 0.813839 Simple median Tophits 0.93
UKB-a:274 Leg fat percentage (right) 2 Body mass index 0.403066 0.016209 1.707407e-136 0.371296 0.434835 Simple median Tophits 0.91
52 Hip circumference 974 Body mass index 0.608307 0.024540 1.182431e-135 0.560210 0.656405 FE IVW DF + HF 0.93
106 Weight 974 Body mass index 0.754016 0.030470 3.378645e-135 0.694295 0.813736 FE IVW DF + HF 0.90
64 Waist circumference 974 Body mass index 0.682888 0.027610 4.696112e-135 0.628772 0.737004 FE IVW DF + HF 0.92
106 Weight 94 Body mass index 0.889413 0.036235 4.787336e-133 0.818393 0.960433 FE IVW HF 0.71
61 Waist circumference 2 Body mass index 0.863653 0.035211 7.467421e-133 0.794640 0.932666 Simple median HF 0.92
999 Body fat 835 Body mass index 0.603196 0.024602 9.487057e-133 0.554976 0.651416 FE IVW Tophits 0.90
UKB-a:285 Arm predicted mass (right) 2 Body mass index 0.416306 0.017238 7.294602e-129 0.382521 0.450091 Penalised median HF 0.96
53 Hip circumference 974 Body mass index 0.641110 0.026581 1.568451e-128 0.589012 0.693209 FE IVW DF + HF 0.94
UKB-a:268 Basal metabolic rate 2 Body mass index 0.459173 0.019154 5.318575e-127 0.421632 0.496714 Simple median Tophits 0.93
60 Waist circumference 2 Body mass index 0.851056 0.035582 1.990089e-126 0.781316 0.920796 Simple median Tophits 0.93
UKB-a:275 Leg fat mass (right) 974 Body mass index 0.608231 0.025618 1.332015e-124 0.558020 0.658442 Weighted median HF 0.94
2 Body mass index 785 Body mass index 0.828436 0.034942 2.916750e-124 0.759950 0.896922 FE IVW DF 0.87
974 Body mass index 835 Body mass index 1.012590 0.042868 2.329665e-123 0.928571 1.096609 Simple median Tophits 0.92
UKB-a:289 Arm predicted mass (left) 2 Body mass index 0.415571 0.017662 2.081872e-122 0.380953 0.450188 Simple median Tophits 0.94
UKB-a:280 Leg fat-free mass (left) 2 Body mass index 0.451352 0.019357 2.975266e-120 0.413413 0.489292 Simple median Tophits 0.92
UKB-a:276 Leg fat-free mass (right) 2 Body mass index 0.438859 0.018829 3.754468e-120 0.401954 0.475764 Simple median Tophits 0.91
UKB-a:249 Weight 835 Body mass index 0.686067 0.029561 3.724643e-119 0.628129 0.744005 Simple median Tophits 0.95
UKB-a:282 Arm fat percentage (right) 835 Body mass index 0.525536 0.022892 1.250557e-116 0.480669 0.570404 Simple median Tophits 0.93
UKB-a:281 Leg predicted mass (left) 2 Body mass index 0.446079 0.019457 2.532056e-116 0.407944 0.484214 Simple median Tophits 0.91
UKB-a:274 Leg fat percentage (right) 835 Body mass index 0.405413 0.017811 1.085615e-114 0.370505 0.440322 Simple median Tophits 0.92
106 Weight 95 Body mass index 0.754770 0.033178 1.466770e-114 0.689741 0.819799 FE IVW HF 0.77
UKB-a:264 Body fat percentage 835 Body mass index 0.504223 0.022493 2.665560e-111 0.460138 0.548307 Simple median Tophits 0.94
UKB-a:266 Whole body fat-free mass 2 Body mass index 0.411821 0.018709 2.214440e-107 0.375152 0.448490 Simple median DF + HF 0.95
98 Hip circumference 835 Body mass index 0.815179 0.037092 4.778391e-107 0.742478 0.887880 FE IVW HF 0.86
UKB-a:283 Arm fat mass (right) 974 Body mass index 0.725155 0.033280 2.899783e-105 0.659928 0.790382 Simple median HF 0.84
77 Waist-to-hip ratio 2 Body mass index 0.543040 0.024979 8.625089e-105 0.494081 0.591999 FE IVW DF + HF 0.81
76 Waist-to-hip ratio 835 Body mass index 0.516216 0.023811 3.205044e-104 0.469546 0.562887 FE IVW DF + HF 0.92
UKB-a:265 Whole body fat mass 785 Body mass index 0.708659 0.032787 1.317384e-103 0.644399 0.772920 Weighted median HF 0.88
UKB-a:284 Arm fat-free mass (right) 2 Body mass index 0.388035 0.017958 1.500477e-103 0.352839 0.423232 Simple median Tophits 0.92
UKB-a:287 Arm fat mass (left) 974 Body mass index 0.718711 0.033304 2.767004e-103 0.653435 0.783986 Simple median HF 0.85
UKB-a:264 Body fat percentage 2 Body mass index 0.488954 0.022713 8.572114e-103 0.444437 0.533470 Weighted median HF 0.91
UKB-a:293 Trunk predicted mass 2 Body mass index 0.357801 0.016665 2.985690e-102 0.325138 0.390465 Simple median Tophits 0.95
UKB-a:248 Body mass index (BMI) 974 Body mass index 0.777636 0.036240 3.847689e-102 0.706607 0.848665 Simple median Tophits 0.92
835 Body mass index 2 Body mass index 1.009931 0.047113 6.100470e-102 0.917592 1.102270 Penalised median HF 0.79
UKB-a:291 Trunk fat mass 974 Body mass index 0.686016 0.032079 1.840705e-101 0.623141 0.748890 Simple median DF 0.96
76 Waist-to-hip ratio 785 Body mass index 0.533825 0.025088 1.806682e-100 0.484653 0.582997 FE IVW DF + HF 0.92
UKB-a:282 Arm fat percentage (right) 785 Body mass index 0.514227 0.024354 5.839075e-99 0.466494 0.561960 Weighted median HF 0.90
UKB-a:279 Leg fat mass (left) 974 Body mass index 0.581341 0.027579 1.243867e-98 0.527286 0.635395 Simple median Tophits 0.93
UKB-a:289 Arm predicted mass (left) 974 Body mass index 0.410427 0.019533 5.062949e-98 0.372144 0.448710 Weighted median HF 0.96
UKB-a:388 Hip circumference 974 Body mass index 0.675198 0.032135 5.147193e-98 0.612216 0.738181 Simple median HF 0.88
UKB-a:286 Arm fat percentage (left) 785 Body mass index 0.509255 0.024238 5.237672e-98 0.461749 0.556760 Weighted median HF 0.93
UKB-a:276 Leg fat-free mass (right) 835 Body mass index 0.430556 0.020526 1.080365e-97 0.390326 0.470786 Simple median HF 0.88
UKB-a:288 Arm fat-free mass (left) 2 Body mass index 0.374304 0.017955 1.642304e-96 0.339112 0.409496 Weighted median HF 0.94
UKB-a:291 Trunk fat mass 94 Body mass index 0.661416 0.031812 5.187594e-96 0.599064 0.723768 FE IVW HF 0.77
UKB-a:278 Leg fat percentage (left) 974 Body mass index 0.378551 0.018294 4.004472e-95 0.342696 0.414406 Simple median Tophits 0.94
93 Overweight 2 Body mass index 1.588370 0.076896 8.593732e-95 1.437657 1.739082 Simple median Tophits 0.90
UKB-a:288 Arm fat-free mass (left) 974 Body mass index 0.411260 0.019980 3.849911e-94 0.372100 0.450420 Weighted median HF 0.95
UKB-a:267 Whole body water mass 2 Body mass index 0.389057 0.018953 1.220020e-93 0.351910 0.426204 Simple median DF + HF 0.95
UKB-a:277 Leg predicted mass (right) 835 Body mass index 0.425946 0.020798 3.227223e-93 0.385183 0.466709 Simple median HF 0.88
65 Waist circumference 835 Body mass index 0.843373 0.041338 1.607565e-92 0.762353 0.924394 Simple median Tophits 0.85
UKB-a:292 Trunk fat-free mass 2 Body mass index 0.360032 0.017734 1.230373e-91 0.325274 0.394789 Simple median Tophits 0.96
UKB-a:268 Basal metabolic rate 835 Body mass index 0.414825 0.020438 1.361234e-91 0.374768 0.454882 Weighted median HF 0.89
UKB-a:248 Body mass index (BMI) 95 Body mass index 0.838542 0.041326 1.552057e-91 0.742015 0.935069 FE IVW HF 0.68
UKB-a:281 Leg predicted mass (left) 785 Body mass index 0.402380 0.019893 5.646703e-91 0.354858 0.449903 FE IVW HF 0.73
90 Obesity class 1 95 Body mass index 2.464755 0.122285 2.390553e-90 2.225077 2.704433 FE IVW HF 0.71
UKB-a:268 Basal metabolic rate 974 Body mass index 0.443559 0.022080 9.191070e-90 0.400284 0.486834 Weighted median HF 0.96
51 Hip circumference 2 Body mass index 0.794124 0.040066 1.989218e-87 0.715596 0.872652 Simple median DF + HF 0.87
93 Overweight 785 Body mass index 1.390330 0.070227 3.122594e-87 1.252685 1.527975 FE IVW DF + HF 0.86
UKB-a:265 Whole body fat mass 94 Body mass index 0.634750 0.032385 1.545958e-85 0.538399 0.731101 FE IVW Tophits 0.79
UKB-a:274 Leg fat percentage (right) 974 Body mass index 0.367955 0.018818 3.857440e-85 0.331073 0.404838 Simple median Tophits 0.94
2 Body mass index 974 Body mass index 0.856419 0.043934 1.255138e-84 0.770309 0.942529 Simple median HF 0.87
785 Body mass index 95 Body mass index 0.776870 0.039951 3.162581e-84 0.698567 0.855173 FE IVW DF + HF 0.68
UKB-a:274 Leg fat percentage (right) 785 Body mass index 0.383945 0.019944 1.378372e-82 0.344856 0.423035 Weighted median HF 0.93
UKB-a:264 Body fat percentage 785 Body mass index 0.469428 0.024428 2.678785e-82 0.421550 0.517306 Penalised median DF + HF 0.88
UKB-a:290 Trunk fat percentage 2 Body mass index 0.526701 0.027474 6.509240e-82 0.472852 0.580549 Weighted median HF 0.93
UKB-a:264 Body fat percentage 974 Body mass index 0.439425 0.022977 1.573731e-81 0.394391 0.484459 Weighted median Tophits 0.91
785 Body mass index 2 Body mass index 0.894302 0.047054 1.523061e-80 0.802078 0.986526 Weighted median DF 0.87
92 Obesity class 3 95 Body mass index 2.001187 0.105376 2.028986e-80 1.794649 2.207724 FE IVW DF 0.77
UKB-a:292 Trunk fat-free mass 974 Body mass index 0.346141 0.018245 2.942469e-80 0.310381 0.381902 Weighted median HF 0.96
62 Waist circumference 835 Body mass index 0.787889 0.041658 8.885664e-80 0.706241 0.869538 Weighted median HF 0.90
62 Waist circumference 785 Body mass index 0.640728 0.034262 4.866790e-78 0.573575 0.707882 FE IVW DF + HF 0.87
63 Waist circumference 2 Body mass index 0.794124 0.042635 1.974155e-77 0.710561 0.877687 Simple median DF + HF 0.87
UKB-a:268 Basal metabolic rate 95 Body mass index 0.413537 0.022210 2.244919e-77 0.323009 0.504065 FE IVW Tophits 0.61
UKB-a:291 Trunk fat mass 785 Body mass index 0.683233 0.036859 1.052488e-76 0.610990 0.755475 Penalised median HF 0.89
85 Extreme body mass index 785 Body mass index 2.061050 0.111597 3.692036e-76 1.842319 2.279780 FE IVW DF + HF 0.82
48 Hip circumference 974 Body mass index 0.734345 0.039937 1.649791e-75 0.656070 0.812619 Simple median Tophits 0.91
UKB-a:290 Trunk fat percentage 974 Body mass index 0.524085 0.028511 1.830549e-75 0.468205 0.579965 Simple median DF 0.93
60 Waist circumference 974 Body mass index 0.745614 0.040608 2.687470e-75 0.666023 0.825205 Simple median Tophits 0.92
90 Obesity class 1 974 Body mass index 2.348346 0.128091 4.477113e-75 2.097292 2.599399 Simple median HF 0.91
835 Body mass index 974 Body mass index 0.871570 0.047573 5.647616e-75 0.778329 0.964811 Simple median HF 0.92
51 Hip circumference 835 Body mass index 0.782609 0.043002 5.218439e-74 0.698326 0.866891 Simple median DF 0.84
102 Waist circumference 785 Body mass index 0.753474 0.041683 4.895986e-73 0.671775 0.835172 FE IVW DF 0.83
UKB-a:293 Trunk predicted mass 974 Body mass index 0.346703 0.019241 1.373825e-72 0.308992 0.384414 Weighted median HF 0.97
51 Hip circumference 974 Body mass index 0.848992 0.047148 1.714414e-72 0.756584 0.941400 Simple median Tophits 0.91
76 Waist-to-hip ratio 94 Body mass index 0.480827 0.026835 8.563853e-72 0.428230 0.533424 FE IVW HF 0.75
64 Waist circumference 2 Body mass index 0.824373 0.046096 1.576710e-71 0.734026 0.914719 Simple median DF + HF 0.91
95 Body mass index 974 Body mass index 0.971723 0.054441 2.932217e-71 0.865021 1.078424 Simple median Tophits 0.88
UKB-a:274 Leg fat percentage (right) 95 Body mass index 0.354654 0.019878 3.354520e-71 0.312462 0.396846 FE IVW HF 0.74
49 Hip circumference 974 Body mass index 0.769507 0.043267 9.219341e-71 0.684705 0.854309 Simple median Tophits 0.91
UKB-a:290 Trunk fat percentage 785 Body mass index 0.526958 0.029728 2.640235e-70 0.468692 0.585224 Simple median DF 0.93
1003 Leptin 2 Body mass index 0.426010 0.024046 3.113782e-70 0.378881 0.473140 FE IVW HF 0.81
UKB-a:267 Whole body water mass 974 Body mass index 0.375213 0.021221 5.896613e-70 0.333619 0.416806 Simple median HF 0.93
63 Waist circumference 835 Body mass index 0.782609 0.044576 5.300596e-69 0.695240 0.869977 Simple median DF 0.84
UKB-a:275 Leg fat mass (right) 94 Body mass index 0.549224 0.031630 1.543556e-67 0.479197 0.619250 FE IVW HF 0.65
UKB-a:35 Comparative height size at age 10 2 Body mass index 0.136684 0.007909 6.495012e-67 0.090511 0.182857 FE IVW Tophits 0.94
UKB-a:266 Whole body fat-free mass 974 Body mass index 0.371810 0.021654 4.435060e-66 0.329369 0.414252 Simple median HF 0.93
UKB-a:292 Trunk fat-free mass 835 Body mass index 0.325766 0.018983 5.235614e-66 0.288559 0.362972 Weighted median HF 0.93
UKB-a:276 Leg fat-free mass (right) 974 Body mass index 0.400692 0.023366 6.438152e-66 0.354896 0.446488 Weighted median HF 0.93
63 Waist circumference 974 Body mass index 0.848992 0.049594 1.070946e-65 0.751790 0.946193 Simple median Tophits 0.91
50 Hip circumference 95 Body mass index 0.818639 0.047997 3.147063e-65 0.724565 0.912712 FE IVW HF 0.66
UKB-a:281 Leg predicted mass (left) 974 Body mass index 0.411265 0.024157 5.403235e-65 0.363918 0.458613 Weighted median HF 0.96
UKB-a:280 Leg fat-free mass (left) 974 Body mass index 0.415162 0.024504 2.191030e-64 0.367135 0.463190 Weighted median HF 0.96
65 Waist circumference 94 Body mass index 0.765009 0.045412 1.121408e-63 0.676002 0.854016 FE IVW DF + HF 0.66
75 Waist-to-hip ratio 974 Body mass index 0.408639 0.024278 1.429372e-63 0.348585 0.468692 FE IVW DF 0.86
UKB-a:382 Waist circumference 785 Body mass index 0.564004 0.033557 2.153143e-63 0.498234 0.629774 Simple median DF 0.85
835 Body mass index 785 Body mass index 0.895307 0.053390 4.090752e-63 0.790665 0.999948 Simple median HF 0.80
61 Waist circumference 785 Body mass index 0.789637 0.047093 4.208715e-63 0.697337 0.881937 Penalised median HF 0.83
91 Obesity class 2 974 Body mass index 3.020408 0.181130 1.981254e-62 2.665399 3.375417 Simple median Tophits 0.88
974 Body mass index 2 Body mass index 1.012872 0.014005 2.426885e-62 0.985421 1.040322 Simple mean HF 0.90
UKB-a:277 Leg predicted mass (right) 974 Body mass index 0.400553 0.024259 3.045845e-61 0.353005 0.448100 Weighted median HF 0.96
UKB-a:293 Trunk predicted mass 835 Body mass index 0.319181 0.019392 7.230109e-61 0.281172 0.357189 Weighted median HF 0.93
UKB-a:285 Arm predicted mass (right) 974 Body mass index 0.333500 0.020526 2.330110e-59 0.293269 0.373731 Weighted median HF 0.97
90 Obesity class 1 2 Body mass index 2.567006 0.049915 4.334818e-59 2.469172 2.664839 Simple mean HF 0.86
62 Waist circumference 94 Body mass index 0.690755 0.042646 5.252105e-59 0.588481 0.793029 FE IVW HF 0.69
76 Waist-to-hip ratio 2 Body mass index 0.600084 0.037057 5.597945e-59 0.527454 0.672714 Simple median DF 0.86
99 Hip circumference 2 Body mass index 0.883978 0.055395 2.514355e-57 0.775406 0.992550 Simple median Tophits 0.85
50 Hip circumference 94 Body mass index 0.693796 0.043749 1.227983e-56 0.593342 0.794249 FE IVW HF 0.73
108 Waist-to-hip ratio 2 Body mass index 0.574619 0.036403 3.955736e-56 0.503269 0.645970 FE IVW Tophits 0.81
72 Waist-to-hip ratio 785 Body mass index 0.388406 0.024657 6.620308e-56 0.336348 0.440464 FE IVW DF 0.90
77 Waist-to-hip ratio 974 Body mass index 0.434574 0.027621 8.960024e-56 0.380436 0.488712 FE IVW DF + HF 0.90
95 Body mass index 2 Body mass index 1.024385 0.021912 4.510179e-55 0.981437 1.067333 Simple mean HF 0.92
UKB-a:284 Arm fat-free mass (right) 974 Body mass index 0.336084 0.021520 5.572092e-55 0.293905 0.378263 Weighted median HF 0.93
48 Hip circumference 95 Body mass index 0.664679 0.042736 1.512551e-54 0.580917 0.748441 FE IVW HF 0.62
UKB-a:34 Comparative body size at age 10 2 Body mass index 0.365580 0.023556 2.550891e-54 0.319411 0.411748 Simple median HF 0.87
91 Obesity class 2 2 Body mass index 3.451995 0.083398 2.091001e-53 3.288536 3.615455 Simple mean HF 0.93
49 Hip circumference 2 Body mass index 0.844333 0.016536 5.602451e-53 0.811923 0.876742 Simple mean HF 0.85
62 Waist circumference 2 Body mass index 0.824785 0.018994 2.342804e-52 0.787556 0.862014 Simple mean HF 0.91
94 Body mass index 785 Body mass index 0.976562 0.064276 3.913645e-52 0.850585 1.102540 Simple median Tophits 0.86
73 Waist-to-hip ratio 94 Body mass index 0.420350 0.027884 2.361303e-51 0.365698 0.475002 FE IVW HF 0.73
63 Waist circumference 94 Body mass index 0.687246 0.045769 5.820248e-51 0.579535 0.794958 FE IVW HF 0.68
51 Hip circumference 94 Body mass index 0.687246 0.045769 5.820248e-51 0.579535 0.794958 FE IVW HF 0.68
90 Obesity class 1 835 Body mass index 2.560321 0.055898 1.218734e-50 2.450762 2.669880 Simple mean HF 0.80
UKB-a:159 Treatment/medication code: metformin 835 Body mass index 0.030020 0.002008 1.593061e-50 0.025009 0.035031 FE IVW DF 0.92
785 Body mass index 835 Body mass index 0.946255 0.016970 2.036356e-49 0.912993 0.979516 RE IVW HF 0.90
UKB-a:264 Body fat percentage 94 Body mass index 0.450260 0.030566 4.091005e-49 0.390352 0.510169 Penalised median DF + HF 0.74
UKB-a:159 Treatment/medication code: metformin 2 Body mass index 0.028589 0.001944 6.091291e-49 0.023228 0.033950 FE IVW DF 0.92
835 Body mass index 94 Body mass index 0.905647 0.061997 2.500317e-48 0.784135 1.027159 Weighted median Tophits 0.69
UKB-a:282 Arm fat percentage (right) 94 Body mass index 0.499245 0.034245 3.850550e-48 0.432125 0.566365 Penalised median DF + HF 0.73
974 Body mass index 785 Body mass index 0.812274 0.055901 7.757418e-48 0.702710 0.921838 Simple median HF 0.86
52 Hip circumference 94 Body mass index 0.685285 0.047188 8.748374e-48 0.579340 0.791229 FE IVW HF 0.67
106 Weight 2 Body mass index 0.906771 0.025762 1.544007e-47 0.856278 0.957264 Simple mean HF 0.92
UKB-a:34 Comparative body size at age 10 835 Body mass index 0.348134 0.024170 4.909722e-47 0.300761 0.395506 Penalised median Tophits 0.84
107 Weight 2 Body mass index 0.938635 0.027133 5.088869e-47 0.885455 0.991815 Simple mean HF 0.93
102 Waist circumference 835 Body mass index 0.855622 0.059431 5.406561e-47 0.739140 0.972104 Simple median Tophits 0.89
95 Body mass index 835 Body mass index 1.009278 0.023845 6.307733e-47 0.962543 1.056014 Simple mean HF 0.94
60 Waist circumference 94 Body mass index 0.779325 0.054457 1.868928e-46 0.672593 0.886058 Penalised median HF 0.69
UKB-a:74 Non-cancer illness code self-reported: diabetes 2 Body mass index 0.034559 0.002418 2.495612e-46 0.027747 0.041370 FE IVW DF 0.93
970 Ulcerative colitis 94 Body mass index 0.520724 0.036548 4.625557e-46 0.449090 0.592357 FE IVW DF 1.00
50 Hip circumference 2 Body mass index 0.883634 0.025804 6.990404e-46 0.833059 0.934209 Simple mean HF 0.87
UKB-a:279 Leg fat mass (left) 2 Body mass index 0.597377 0.014576 1.406770e-45 0.568809 0.625945 Simple mean DF + HF 0.93
48 Hip circumference 835 Body mass index 0.792715 0.016935 2.139317e-45 0.759522 0.825908 Simple mean HF 0.94
94 Body mass index 974 Body mass index 0.863309 0.061300 4.802027e-45 0.743164 0.983454 Simple median Tophits 0.94
UKB-a:388 Hip circumference 95 Body mass index 0.616571 0.043891 7.949417e-45 0.530545 0.702597 FE IVW HF 0.67
UKB-a:279 Leg fat mass (left) 94 Body mass index 0.584335 0.041826 2.350963e-44 0.502359 0.666312 Penalised median HF 0.64
UKB-a:159 Treatment/medication code: metformin 974 Body mass index 0.028050 0.002010 3.042889e-44 0.022724 0.033375 FE IVW DF 0.91
UKB-a:382 Waist circumference 94 Body mass index 0.631863 0.045502 7.652002e-44 0.542680 0.721045 Penalised median HF 0.67
49 Hip circumference 835 Body mass index 0.815661 0.018299 1.077226e-43 0.779794 0.851527 Simple mean HF 0.93
108 Waist-to-hip ratio 785 Body mass index 0.543250 0.039339 2.231595e-43 0.466146 0.620354 FE IVW Tophits 0.85
91 Obesity class 2 835 Body mass index 3.241346 0.091339 2.332824e-43 3.062322 3.420371 RE IVW HF 0.88
94 Body mass index 835 Body mass index 1.003683 0.029162 5.254397e-43 0.946526 1.060840 RE IVW HF 0.95
73 Waist-to-hip ratio 2 Body mass index 0.491476 0.015019 6.236471e-43 0.462038 0.520913 RE IVW DF + HF 0.92
106 Weight 835 Body mass index 0.901261 0.025843 6.626908e-43 0.850609 0.951912 Simple mean HF 0.94
76 Waist-to-hip ratio 95 Body mass index 0.484389 0.035377 1.127449e-42 0.415051 0.553727 FE IVW Tophits 0.73
103 Waist circumference 974 Body mass index 0.792079 0.057989 1.779185e-42 0.678423 0.905735 Simple median Tophits 0.87
2 Body mass index 94 Body mass index 0.803025 0.058909 2.599257e-42 0.687565 0.918485 Weighted median Tophits 0.71
53 Hip circumference 835 Body mass index 0.775053 0.024032 4.008799e-42 0.727950 0.822156 Simple mean HF 0.84
UKB-a:265 Whole body fat mass 2 Body mass index 0.727284 0.020433 1.414054e-41 0.687235 0.767333 Simple mean DF + HF 0.92
UKB-a:252 Long-standing illness disability or infirmity 2 Body mass index 0.065335 0.004855 2.756851e-41 0.055820 0.074850 FE IVW DF + HF 0.95
999 Body fat 2 Body mass index 0.614166 0.021385 3.598232e-41 0.572252 0.656081 Simple mean HF 0.92
UKB-a:252 Long-standing illness disability or infirmity 974 Body mass index 0.069359 0.005163 3.856388e-41 0.059240 0.079479 FE IVW DF + HF 0.93
108 Waist-to-hip ratio 94 Body mass index 0.565571 0.042154 4.827483e-41 0.482948 0.648193 FE IVW Tophits 0.70
103 Waist circumference 2 Body mass index 0.775547 0.024325 5.392015e-41 0.727870 0.823224 Simple mean DF + HF 0.91
UKB-a:283 Arm fat mass (right) 94 Body mass index 0.722513 0.053984 7.509525e-41 0.616707 0.828319 Weighted median HF 0.63
72 Waist-to-hip ratio 2 Body mass index 0.464905 0.015386 9.304830e-41 0.434749 0.495061 Simple mean HF 0.93
52 Hip circumference 835 Body mass index 0.756415 0.024050 1.222139e-40 0.709277 0.803552 Simple mean HF 0.89
UKB-a:290 Trunk fat percentage 94 Body mass index 0.487894 0.036637 1.845550e-40 0.416086 0.559701 Penalised median DF + HF 0.77
92 Obesity class 3 2 Body mass index 4.000875 0.154425 7.492303e-39 3.698202 4.303548 Simple mean HF 0.82
48 Hip circumference 785 Body mass index 0.699482 0.053741 9.962167e-39 0.594151 0.804813 Simple median Tophits 0.85
49 Hip circumference 94 Body mass index 0.796924 0.061343 1.370505e-38 0.676695 0.917154 Penalised median HF 0.72
UKB-a:437 Vascular/heart problems diagnosed by doctor: H... 974 Body mass index 0.073632 0.005694 3.023728e-38 0.055553 0.091710 FE IVW Tophits 0.92
99 Hip circumference 835 Body mass index 0.866498 0.031239 4.275475e-38 0.805269 0.927728 Simple mean HF 0.89
UKB-a:266 Whole body fat-free mass 785 Body mass index 0.365899 0.028421 6.274400e-38 0.310195 0.421602 Weighted median HF 0.72
999 Body fat 94 Body mass index 0.500946 0.039075 1.264909e-37 0.405529 0.596364 FE IVW HF 0.75
UKB-a:286 Arm fat percentage (left) 835 Body mass index 0.504866 0.013632 1.720177e-37 0.478148 0.531584 RE IVW DF + HF 0.93
UKB-a:388 Hip circumference 835 Body mass index 0.689908 0.019755 2.788821e-37 0.651187 0.728628 Simple mean HF 0.92
103 Waist circumference 94 Body mass index 0.737582 0.058107 6.421457e-37 0.623693 0.851472 FE IVW HF 0.68
UKB-a:269 Impedance of whole body 974 Body mass index -0.330122 0.026103 1.165901e-36 -0.381283 -0.278960 Penalised median DF 0.65
98 Hip circumference 2 Body mass index 0.789685 0.033514 2.108723e-36 0.723997 0.855372 RE IVW HF 0.87
51 Hip circumference 785 Body mass index 0.685279 0.054495 2.898139e-36 0.578470 0.792088 Simple median HF 0.85
102 Waist circumference 2 Body mass index 0.839777 0.035591 3.623785e-36 0.770019 0.909534 Simple mean HF 0.86
302 Triglycerides 835 Body mass index 0.234677 0.018696 3.855613e-36 0.198033 0.271320 FE IVW DF + HF 0.93
UKB-a:251 Overall health rating 974 Body mass index 0.119201 0.009540 7.955900e-36 0.097566 0.140836 FE IVW HF 0.89
UKB-a:291 Trunk fat mass 835 Body mass index 0.706588 0.022322 3.372180e-35 0.662836 0.750340 Simple mean HF 0.92
UKB-a:278 Leg fat percentage (left) 835 Body mass index 0.389378 0.012039 3.450526e-35 0.365782 0.412974 Simple mean HF 0.92
72 Waist-to-hip ratio 835 Body mass index 0.438427 0.015363 4.758316e-35 0.408315 0.468539 Simple mean HF 0.91
73 Waist-to-hip ratio 785 Body mass index 0.428702 0.034768 6.216472e-35 0.360558 0.496846 Weighted median DF + HF 0.92
73 Waist-to-hip ratio 835 Body mass index 0.449910 0.015850 6.288073e-35 0.418845 0.480976 Simple mean HF 0.91
64 Waist circumference 95 Body mass index 0.658256 0.053435 7.170463e-35 0.548608 0.767905 FE IVW HF 0.77
1003 Leptin 785 Body mass index 0.407815 0.033257 1.441695e-34 0.342631 0.472999 FE IVW DF + HF 0.82
UKB-a:289 Arm predicted mass (left) 835 Body mass index 0.387827 0.011776 4.026005e-34 0.364746 0.410908 Simple mean HF 0.93
74 Waist-to-hip ratio 785 Body mass index 0.354757 0.029142 4.297500e-34 0.297640 0.411875 FE IVW DF + HF 0.86
UKB-a:61 Non-cancer illness code self-reported: hyperte... 785 Body mass index 0.082145 0.006755 5.067997e-34 0.068905 0.095386 FE IVW HF 0.79
UKB-a:288 Arm fat-free mass (left) 835 Body mass index 0.395217 0.011551 7.405304e-34 0.372578 0.417857 Simple mean HF 0.91
302 Triglycerides 2 Body mass index 0.197199 0.016332 1.438659e-33 0.145613 0.248785 FE IVW Tophits 0.93
92 Obesity class 3 835 Body mass index 3.919266 0.165545 4.620962e-33 3.594798 4.243734 Simple mean HF 0.83
98 Hip circumference 95 Body mass index 0.634012 0.053139 8.129560e-33 0.529860 0.738163 FE IVW HF 0.73
UKB-a:284 Arm fat-free mass (right) 835 Body mass index 0.364038 0.011880 1.026547e-32 0.340754 0.387322 Simple mean HF 0.96
UKB-a:285 Arm predicted mass (right) 835 Body mass index 0.376105 0.012086 1.508521e-32 0.352416 0.399794 Simple mean HF 0.94
1003 Leptin 94 Body mass index 0.407197 0.034349 2.036378e-32 0.339872 0.474521 FE IVW DF 0.71
63 Waist circumference 785 Body mass index 0.685279 0.058112 4.274844e-32 0.571381 0.799177 Simple median HF 0.85
UKB-a:280 Leg fat-free mass (left) 835 Body mass index 0.443869 0.014098 8.153676e-32 0.416237 0.471501 Simple mean HF 0.87
UKB-a:490 Medication for cholesterol blood pressure or d... 2 Body mass index 0.085358 0.007301 1.400380e-31 0.061614 0.109102 FE IVW Tophits 0.92
UKB-a:281 Leg predicted mass (left) 835 Body mass index 0.438595 0.014184 1.742397e-31 0.410795 0.466395 Simple mean HF 0.87
UKB-a:280 Leg fat-free mass (left) 785 Body mass index 0.352275 0.030212 2.041050e-31 0.293060 0.411490 Weighted median HF 0.74
835 Body mass index 95 Body mass index 0.870877 0.074794 2.472932e-31 0.724283 1.017471 Simple median Tophits 0.70
93 Overweight 94 Body mass index 1.508385 0.129871 3.480536e-31 1.253841 1.762928 Penalised median HF 0.85
93 Overweight 974 Body mass index 1.567888 0.038771 5.662724e-31 1.491897 1.643878 RE IVW HF 0.85
UKB-a:264 Body fat percentage 95 Body mass index 0.406235 0.035203 8.325580e-31 0.337237 0.475232 Weighted median Tophits 0.67
2 Body mass index 95 Body mass index 0.861012 0.074801 1.164246e-30 0.714406 1.007618 Penalised median DF + HF 0.71
UKB-a:291 Trunk fat mass 95 Body mass index 0.565574 0.049469 2.861342e-30 0.468617 0.662530 Penalised median Tophits 0.66
UKB-a:278 Leg fat percentage (left) 95 Body mass index 0.314500 0.027776 1.011325e-29 0.260060 0.368939 Penalised median DF + HF 0.73
UKB-a:251 Overall health rating 785 Body mass index 0.115943 0.010273 1.531115e-29 0.079913 0.151974 FE IVW Tophits 0.86
107 Weight 974 Body mass index 0.882714 0.019052 1.790006e-29 0.845371 0.920056 Simple mean DF + HF 0.91
UKB-a:283 Arm fat mass (right) 95 Body mass index 0.662665 0.058791 1.813844e-29 0.547437 0.777893 Simple median Tophits 0.67
48 Hip circumference 94 Body mass index 0.631729 0.056182 2.470214e-29 0.521614 0.741844 Penalised median HF 0.70
99 Hip circumference 974 Body mass index 0.846246 0.025160 8.540799e-29 0.796932 0.895560 Simple mean HF 0.85
102 Waist circumference 974 Body mass index 0.742358 0.066708 9.119701e-29 0.611613 0.873103 Simple median Tophits 0.89
UKB-a:306 Diabetes diagnosed by doctor 835 Body mass index 0.045937 0.004130 9.729021e-29 0.037842 0.054031 Simple median Tophits 0.93
UKB-a:287 Arm fat mass (left) 95 Body mass index 0.629947 0.056666 1.039337e-28 0.518883 0.741011 Weighted median DF 0.68
75 Waist-to-hip ratio 2 Body mass index 0.420205 0.022769 2.159866e-28 0.375577 0.464833 Simple mean HF 0.93
93 Overweight 95 Body mass index 1.548658 0.140166 2.223651e-28 1.273937 1.823379 Penalised median HF 0.80
UKB-a:276 Leg fat-free mass (right) 785 Body mass index 0.320864 0.029178 3.963762e-28 0.263675 0.378052 Weighted median HF 0.73
UKB-a:272 Impedance of arm (right) 785 Body mass index -0.342056 0.031109 4.024899e-28 -0.403029 -0.281083 Weighted median Tophits 0.70
UKB-a:285 Arm predicted mass (right) 785 Body mass index 0.281946 0.025757 6.912521e-28 0.231463 0.332428 Penalised median DF + HF 0.65
UKB-a:24 Number of treatments/medications taken 2 Body mass index 0.108110 0.009880 7.207905e-28 0.088746 0.127474 FE IVW DF + HF 0.92
74 Waist-to-hip ratio 95 Body mass index 0.371824 0.034030 8.633253e-28 0.289790 0.453858 FE IVW Tophits 0.77
50 Hip circumference 974 Body mass index 0.835788 0.017708 1.743780e-27 0.801080 0.870496 RE IVW HF 0.92
UKB-a:267 Whole body water mass 785 Body mass index 0.288805 0.026618 1.991773e-27 0.236635 0.340975 Penalised median DF + HF 0.75
74 Waist-to-hip ratio 2 Body mass index 0.408649 0.023206 2.010071e-27 0.363164 0.454134 Simple mean HF 0.90
62 Waist circumference 974 Body mass index 0.827786 0.018901 2.452401e-27 0.790739 0.864832 RE IVW HF 0.92
102 Waist circumference 95 Body mass index 0.690950 0.063842 2.685417e-27 0.565819 0.816081 FE IVW Tophits 0.69
UKB-a:159 Treatment/medication code: metformin 94 Body mass index 0.032237 0.002982 3.106401e-27 0.023831 0.040643 FE IVW Tophits 0.72
75 Waist-to-hip ratio 95 Body mass index 0.369257 0.034197 3.517090e-27 0.285658 0.452855 FE IVW Tophits 0.77
UKB-a:279 Leg fat mass (left) 95 Body mass index 0.468288 0.043508 5.127045e-27 0.383015 0.553562 Penalised median HF 0.66
UKB-a:34 Comparative body size at age 10 974 Body mass index 0.310850 0.028958 6.997133e-27 0.254094 0.367606 Weighted median DF 0.83
77 Waist-to-hip ratio 835 Body mass index 0.487578 0.026920 7.005283e-27 0.434815 0.540341 Simple mean HF 0.90
UKB-a:139 Treatment/medication code: gliclazide 835 Body mass index 0.010705 0.000997 7.034502e-27 0.008750 0.012660 FE IVW DF + HF 0.91
UKB-a:74 Non-cancer illness code self-reported: diabetes 94 Body mass index 0.039774 0.003707 7.345221e-27 0.032107 0.047441 FE IVW DF + HF 0.75
2 Body mass index 835 Body mass index 0.968708 0.006268 7.914895e-27 0.956424 0.980993 RE IVW DF + HF 0.68
UKB-a:287 Arm fat mass (left) 94 Body mass index 0.611261 0.057283 1.391872e-26 0.498989 0.723533 Weighted median DF + HF 0.64
95 Body mass index 94 Body mass index 0.828641 0.077830 1.804355e-26 0.676097 0.981184 Weighted median DF + HF 0.80
74 Waist-to-hip ratio 974 Body mass index 0.410557 0.038632 2.224351e-26 0.334839 0.486275 Simple median HF 0.90
UKB-a:275 Leg fat mass (right) 95 Body mass index 0.525958 0.049669 3.339779e-26 0.428609 0.623307 Weighted median Tophits 0.65
UKB-a:276 Leg fat-free mass (right) 95 Body mass index 0.413464 0.039132 4.283506e-26 0.336768 0.490160 Simple median DF + HF 0.61
85 Extreme body mass index 974 Body mass index 3.744693 0.120683 5.393300e-26 3.508155 3.981232 Simple mean HF 0.83
103 Waist circumference 785 Body mass index 0.786241 0.074905 8.958748e-26 0.639430 0.933051 Simple median HF 0.84
UKB-a:476 Pain type(s) experienced in last month: Knee pain 2 Body mass index 0.048850 0.004668 1.264833e-25 0.036242 0.061458 FE IVW Tophits 0.87
UKB-a:437 Vascular/heart problems diagnosed by doctor: H... 2 Body mass index 0.091326 0.008743 1.543622e-25 0.074189 0.108463 Weighted median HF 0.93
61 Waist circumference 974 Body mass index 0.754081 0.015793 2.646532e-25 0.723126 0.785036 Simple mean HF 0.94
UKB-a:265 Whole body fat mass 95 Body mass index 0.550788 0.053080 3.169058e-25 0.446753 0.654822 Penalised median Tophits 0.63
UKB-a:292 Trunk fat-free mass 95 Body mass index 0.339848 0.032763 3.295016e-25 0.275633 0.404063 Penalised median Tophits 0.69
UKB-a:277 Leg predicted mass (right) 785 Body mass index 0.318503 0.030796 4.539377e-25 0.258143 0.378863 Weighted median HF 0.73
74 Waist-to-hip ratio 94 Body mass index 0.342128 0.033088 4.651455e-25 0.277275 0.406980 FE IVW HF 0.72
UKB-a:388 Hip circumference 94 Body mass index 0.562156 0.054575 6.995156e-25 0.455192 0.669120 Simple median Tophits 0.67
UKB-a:25 Alcohol intake frequency. 95 Body mass index 0.241218 0.023446 7.961931e-25 0.195264 0.287172 FE IVW HF 0.77
999 Body fat 974 Body mass index 0.562883 0.021441 1.289777e-24 0.520859 0.604907 RE IVW HF 0.92
UKB-a:382 Waist circumference 974 Body mass index 0.581712 0.017653 1.557456e-24 0.547112 0.616312 RE IVW DF + HF 0.94
UKB-a:285 Arm predicted mass (right) 95 Body mass index 0.343645 0.033675 1.890553e-24 0.277643 0.409648 Penalised median DF 0.72
UKB-a:315 Age when periods started (menarche) 95 Body mass index -0.398999 0.039128 2.040931e-24 -0.475689 -0.322309 Penalised median HF 0.65
UKB-a:293 Trunk predicted mass 95 Body mass index 0.338241 0.033209 2.307374e-24 0.273153 0.403329 Penalised median Tophits 0.67
UKB-a:251 Overall health rating 95 Body mass index 0.107661 0.010572 2.336570e-24 0.086941 0.128381 FE IVW HF 0.87
77 Waist-to-hip ratio 785 Body mass index 0.512821 0.050477 3.008684e-24 0.413887 0.611754 Simple median HF 0.87
99 Hip circumference 785 Body mass index 0.725693 0.071504 3.345931e-24 0.585549 0.865838 Simple median HF 0.86
UKB-a:74 Non-cancer illness code self-reported: diabetes 95 Body mass index 0.031864 0.003141 3.525153e-24 0.025707 0.038020 FE IVW HF 0.79
75 Waist-to-hip ratio 835 Body mass index 0.414563 0.024182 3.661284e-24 0.367167 0.461959 Simple mean HF 0.90
UKB-a:22 Number of self-reported non-cancer illnesses 835 Body mass index 0.104521 0.010388 8.163615e-24 0.073614 0.135428 FE IVW Tophits 0.90
UKB-a:265 Whole body fat mass 974 Body mass index 0.682156 0.022059 9.360806e-24 0.638920 0.725393 Simple mean HF 0.86
UKB-a:208 Illnesses of father: Diabetes 94 Body mass index 0.042355 0.004248 2.032788e-23 0.034030 0.050680 FE IVW HF 0.76
UKB-a:249 Weight 95 Body mass index 0.486719 0.048872 2.303452e-23 0.390931 0.582507 Penalised median Tophits 0.66
785 Body mass index 974 Body mass index 0.802167 0.028151 2.783834e-23 0.746990 0.857343 Simple mean HF 0.93
73 Waist-to-hip ratio 974 Body mass index 0.414488 0.015726 2.856419e-23 0.383666 0.445311 Simple mean HF 0.93
UKB-a:270 Impedance of leg (right) 95 Body mass index -0.547014 0.055087 3.079588e-23 -0.654982 -0.439047 Weighted median DF 0.62
UKB-a:139 Treatment/medication code: gliclazide 94 Body mass index 0.010669 0.001082 6.026014e-23 0.008548 0.012789 FE IVW HF 0.75
768 Fasting insulin 2 Body mass index 0.179708 0.018256 7.294701e-23 0.135706 0.223711 FE IVW Tophits 0.87
72 Waist-to-hip ratio 974 Body mass index 0.402724 0.016310 7.469973e-23 0.370757 0.434691 Simple mean HF 0.93
94 Body mass index 95 Body mass index 0.689665 0.070189 8.714190e-23 0.485705 0.893626 FE IVW DF 0.73
92 Obesity class 3 974 Body mass index 3.707439 0.160538 9.027601e-23 3.392785 4.022093 Simple mean Tophits 0.86
65 Waist circumference 974 Body mass index 0.689142 0.027277 1.042065e-22 0.635680 0.742605 RE IVW HF 0.92
74 Waist-to-hip ratio 835 Body mass index 0.385743 0.024998 1.483248e-22 0.336747 0.434739 Simple mean HF 0.90
UKB-a:290 Trunk fat percentage 95 Body mass index 0.404059 0.041682 3.203263e-22 0.322364 0.485755 Penalised median HF 0.67
72 Waist-to-hip ratio 95 Body mass index 0.400807 0.041386 3.504464e-22 0.319692 0.481922 Penalised median HF 0.79
UKB-a:74 Non-cancer illness code self-reported: diabetes 835 Body mass index 0.035783 0.003700 3.948704e-22 0.028532 0.043034 Simple median Tophits 0.92
UKB-a:223 Illnesses of siblings: Diabetes 2 Body mass index 0.033829 0.003502 4.499031e-22 0.020890 0.046768 FE IVW Tophits 0.94
785 Body mass index 94 Body mass index 0.768266 0.079685 5.350304e-22 0.612087 0.924446 Weighted median DF 0.71
1055 Urate 974 Body mass index 0.283304 0.029433 6.256694e-22 0.225614 0.340993 FE IVW DF + HF 0.90
UKB-a:139 Treatment/medication code: gliclazide 2 Body mass index 0.009995 0.001039 6.516356e-22 0.007748 0.012241 FE IVW DF 0.92
UKB-a:288 Arm fat-free mass (left) 95 Body mass index 0.360003 0.037467 7.352044e-22 0.286570 0.433436 Penalised median HF 0.62
UKB-a:216 Illnesses of mother: Diabetes 835 Body mass index 0.032549 0.003391 8.019535e-22 0.025903 0.039194 FE IVW DF + HF 0.87
60 Waist circumference 95 Body mass index 0.639955 0.066861 1.054009e-21 0.508910 0.770999 Penalised median HF 0.78
UKB-a:277 Leg predicted mass (right) 95 Body mass index 0.410942 0.043003 1.222690e-21 0.326658 0.495227 Simple median DF + HF 0.61
UKB-a:450 Medication for cholesterol blood pressure diab... 2 Body mass index 0.056120 0.005914 2.312766e-21 0.037927 0.074313 FE IVW Tophits 0.89
302 Triglycerides 974 Body mass index 0.174881 0.018498 3.259182e-21 0.136818 0.212944 FE IVW DF + HF 0.89
768 Fasting insulin 835 Body mass index 0.174981 0.018534 3.693128e-21 0.138654 0.211308 FE IVW HF 0.90
770 HOMA-B 2 Body mass index 0.122380 0.012974 3.988144e-21 0.096951 0.147808 FE IVW DF + HF 0.90
108 Waist-to-hip ratio 835 Body mass index 0.484459 0.034563 4.947126e-21 0.416716 0.552203 Simple mean HF 0.79
UKB-a:280 Leg fat-free mass (left) 95 Body mass index 0.398236 0.042394 5.799954e-21 0.315144 0.481327 Simple median Tophits 0.62
61 Waist circumference 95 Body mass index 0.659848 0.070564 8.677908e-21 0.521545 0.798150 Penalised median Tophits 0.65
UKB-a:139 Treatment/medication code: gliclazide 974 Body mass index 0.009668 0.001038 1.245483e-20 0.007633 0.011702 FE IVW Tophits 0.90
UKB-a:275 Leg fat mass (right) 785 Body mass index 0.596800 0.018762 1.620215e-20 0.560027 0.633572 Simple mean HF 0.93
UKB-a:216 Illnesses of mother: Diabetes 2 Body mass index 0.030881 0.003341 2.403442e-20 0.024332 0.037429 FE IVW DF + HF 0.91
53 Hip circumference 785 Body mass index 0.785461 0.023800 3.111168e-20 0.738812 0.832109 Simple mean DF + HF 0.90
UKB-a:276 Leg fat-free mass (right) 94 Body mass index 0.327541 0.035579 3.384020e-20 0.257807 0.397274 Simple median DF + HF 0.69
98 Hip circumference 974 Body mass index 0.646736 0.032091 4.052406e-20 0.583838 0.709634 RE IVW HF 0.89
95 Body mass index 785 Body mass index 0.742857 0.080902 4.223257e-20 0.584293 0.901422 Simple median Tophits 0.83
106 Weight 785 Body mass index 0.902158 0.035293 5.958015e-20 0.832983 0.971332 Simple mean HF 0.87
UKB-a:279 Leg fat mass (left) 785 Body mass index 0.586546 0.018427 6.782123e-20 0.550429 0.622662 RE IVW HF 0.93
UKB-a:61 Non-cancer illness code self-reported: hyperte... 94 Body mass index 0.097966 0.010734 7.080232e-20 0.076927 0.119005 Penalised median HF 0.76
UKB-a:284 Arm fat-free mass (right) 95 Body mass index 0.330234 0.036201 7.349800e-20 0.259283 0.401186 Penalised median HF 0.64
UKB-a:249 Weight 94 Body mass index 0.589100 0.064696 8.572320e-20 0.462298 0.715902 Simple median HF 0.63
UKB-a:306 Diabetes diagnosed by doctor 2 Body mass index 0.041593 0.004572 9.333042e-20 0.032631 0.050554 Weighted median HF 0.93
UKB-a:490 Medication for cholesterol blood pressure or d... 974 Body mass index 0.080067 0.008846 1.413128e-19 0.062608 0.097526 FE IVW DF + HF 0.84
65 Waist circumference 95 Body mass index 0.647887 0.071588 1.427114e-19 0.507577 0.788198 Simple median Tophits 0.79
UKB-a:249 Weight 974 Body mass index 0.603638 0.021014 1.600083e-19 0.562451 0.644825 RE IVW DF + HF 0.90
UKB-a:278 Leg fat percentage (left) 785 Body mass index 0.389290 0.015209 1.874507e-19 0.359480 0.419100 Simple mean HF 0.92
UKB-a:222 Illnesses of siblings: High blood pressure 835 Body mass index 0.050879 0.005648 2.085517e-19 0.039809 0.061948 FE IVW DF + HF 0.88
UKB-a:277 Leg predicted mass (right) 94 Body mass index 0.324507 0.036047 2.208013e-19 0.253857 0.395158 Simple median DF + HF 0.68
UKB-a:223 Illnesses of siblings: Diabetes 835 Body mass index 0.034520 0.003847 2.905739e-19 0.026979 0.042062 FE IVW HF 0.93
UKB-a:335 Sodium in urine 2 Body mass index 0.098866 0.011036 3.294473e-19 0.055201 0.142532 FE IVW Tophits 0.82
73 Waist-to-hip ratio 95 Body mass index 0.407955 0.045611 3.746215e-19 0.318559 0.497350 Penalised median DF 0.84
UKB-a:222 Illnesses of siblings: High blood pressure 2 Body mass index 0.045974 0.005166 5.602729e-19 0.030430 0.061518 FE IVW Tophits 0.90
UKB-a:488 Medication for cholesterol blood pressure or d... 2 Body mass index 0.062939 0.007080 6.107266e-19 0.038429 0.087450 FE IVW Tophits 0.91
63 Waist circumference 95 Body mass index 0.675288 0.075978 6.224436e-19 0.526374 0.824202 Penalised median Tophits 0.63
UKB-a:24 Number of treatments/medications taken 835 Body mass index 0.096224 0.010834 6.582638e-19 0.074990 0.117459 FE IVW DF + HF 0.92
UKB-a:281 Leg predicted mass (left) 95 Body mass index 0.396929 0.044711 6.822504e-19 0.309298 0.484560 Simple median Tophits 0.62
UKB-a:34 Comparative body size at age 10 95 Body mass index 0.410797 0.046468 9.534537e-19 0.270586 0.551008 FE IVW DF + HF 0.67
UKB-a:153 Treatment/medication code: insulin product 2 Body mass index 0.008843 0.001011 2.181925e-18 0.006861 0.010824 FE IVW DF + HF 0.89
UKB-a:287 Arm fat mass (left) 785 Body mass index 0.731144 0.027282 2.726717e-18 0.677670 0.784617 Simple mean HF 0.88
51 Hip circumference 95 Body mass index 0.675288 0.077787 3.915109e-18 0.522828 0.827748 Penalised median Tophits 0.63
UKB-a:61 Non-cancer illness code self-reported: hyperte... 2 Body mass index 0.082804 0.006634 4.501768e-18 0.069802 0.095806 Simple mean DF + HF 0.93
UKB-a:310 Taking other prescription medications 2 Body mass index 0.049094 0.005674 5.050770e-18 0.031634 0.066554 FE IVW Tophits 0.87
UKB-a:283 Arm fat mass (right) 785 Body mass index 0.734739 0.028243 5.143168e-18 0.679382 0.790097 Simple mean HF 0.87
UKB-a:150 Treatment/medication code: amlodipine 2 Body mass index 0.017493 0.002023 5.317829e-18 0.013528 0.021459 FE IVW HF 0.89
UKB-a:559 Diagnoses - main ICD10: K80 Cholelithiasis 2 Body mass index 0.012078 0.001397 5.384128e-18 0.009340 0.014817 FE IVW HF 0.85
107 Weight 95 Body mass index 0.891616 0.103373 6.396501e-18 0.689008 1.094223 Penalised median HF 0.71
999 Body fat 785 Body mass index 0.593353 0.025682 6.625010e-18 0.543016 0.643691 Simple mean HF 0.92
UKB-a:22 Number of self-reported non-cancer illnesses 2 Body mass index 0.102070 0.008432 7.260774e-18 0.085544 0.118596 RE IVW DF + HF 0.93
109 Waist-to-hip ratio 2 Body mass index 0.347237 0.029750 1.059922e-17 0.288927 0.405548 Simple mean DF + HF 0.88
775 Fasting insulin 2 Body mass index 0.161156 0.014138 1.064233e-17 0.133446 0.188865 Simple mean HF 0.91
UKB-a:306 Diabetes diagnosed by doctor 785 Body mass index 0.046201 0.005412 1.386822e-17 0.035593 0.056809 Simple median Tophits 0.83
UKB-a:490 Medication for cholesterol blood pressure or d... 95 Body mass index 0.101288 0.011868 1.409070e-17 0.078027 0.124550 FE IVW HF 0.81
76 Waist-to-hip ratio 974 Body mass index 0.430225 0.026552 1.471659e-17 0.378183 0.482268 Simple mean HF 0.94
UKB-a:61 Non-cancer illness code self-reported: hyperte... 835 Body mass index 0.081862 0.006377 1.903875e-17 0.069363 0.094362 Simple mean DF + HF 0.92
1055 Urate 835 Body mass index 0.361767 0.029225 2.902077e-17 0.304485 0.419048 Simple mean HF 0.94
1003 Leptin 835 Body mass index 0.430911 0.051310 4.536788e-17 0.330345 0.531478 Weighted median DF 0.80
49 Hip circumference 785 Body mass index 0.755560 0.026549 4.825808e-17 0.703525 0.807595 RE IVW DF + HF 0.85
62 Waist circumference 95 Body mass index 0.673188 0.080470 5.975759e-17 0.515470 0.830907 Penalised median HF 0.64
UKB-a:251 Overall health rating 2 Body mass index 0.116215 0.009949 7.172436e-17 0.096716 0.135714 RE IVW DF + HF 0.88
UKB-a:25 Alcohol intake frequency. 974 Body mass index 0.264775 0.031734 7.200695e-17 0.202578 0.326972 Weighted median HF 0.92
13 Crohn's disease 95 Body mass index 1.232424 0.147750 7.347528e-17 0.942835 1.522013 FE IVW DF 1.00
UKB-a:35 Comparative height size at age 10 835 Body mass index 0.163507 0.019648 8.657835e-17 0.124998 0.202016 Simple median DF + HF 0.91
UKB-a:475 Pain type(s) experienced in last month: Hip pain 2 Body mass index 0.040069 0.003722 9.990363e-17 0.032774 0.047364 Simple mean HF 0.88
UKB-a:475 Pain type(s) experienced in last month: Hip pain 835 Body mass index 0.033886 0.004091 1.192083e-16 0.025628 0.042144 FE IVW DF + HF 0.88
UKB-a:121 Treatment/medication code: simvastatin 2 Body mass index 0.031216 0.003779 1.456319e-16 0.023809 0.038623 FE IVW DF + HF 0.91
1055 Urate 95 Body mass index 0.344392 0.041789 1.706129e-16 0.246265 0.442519 FE IVW HF 0.81
UKB-a:359 Diastolic blood pressure automated reading 2 Body mass index 0.126295 0.015338 1.805636e-16 0.095002 0.157587 FE IVW DF + HF 0.87
65 Waist circumference 785 Body mass index 0.775185 0.031601 2.122153e-16 0.713246 0.837124 Simple mean HF 0.89
1055 Urate 2 Body mass index 0.366601 0.044847 2.972839e-16 0.278702 0.454501 Simple median HF 0.92
UKB-a:74 Non-cancer illness code self-reported: diabetes 785 Body mass index 0.038480 0.004727 3.947617e-16 0.029215 0.047745 Simple median Tophits 0.87
UKB-a:284 Arm fat-free mass (right) 94 Body mass index 0.252342 0.031007 4.007391e-16 0.191570 0.313113 Penalised median Tophits 0.68
98 Hip circumference 785 Body mass index 0.729539 0.041205 1.172604e-15 0.648778 0.810300 Simple mean DF + HF 0.89
1033 Height 95 Body mass index 0.495345 0.061896 1.215244e-15 0.374029 0.616661 FE IVW HF 0.74
203 CD4mem:%Th22 94 Body mass index 0.102034 0.012776 1.392291e-15 0.076993 0.127076 FE IVW DF 0.72
UKB-a:490 Medication for cholesterol blood pressure or d... 835 Body mass index 0.092458 0.008269 1.471313e-15 0.076250 0.108666 RE IVW DF + HF 0.95
UKB-a:74 Non-cancer illness code self-reported: diabetes 974 Body mass index 0.030464 0.003824 1.635669e-15 0.022969 0.037960 Simple median HF 0.94
60 Waist circumference 785 Body mass index 0.724392 0.030904 1.746764e-15 0.663820 0.784965 RE IVW DF + HF 0.84
771 HOMA-IR 785 Body mass index 0.187912 0.023619 1.775209e-15 0.134989 0.240834 FE IVW DF 0.86
UKB-a:108 Non-cancer illness code self-reported: high ch... 974 Body mass index 0.028766 0.003633 2.413154e-15 0.021645 0.035886 FE IVW DF + HF 0.81
UKB-a:153 Treatment/medication code: insulin product 835 Body mass index 0.008441 0.001069 2.857532e-15 0.006346 0.010536 FE IVW DF + HF 0.86
UKB-a:306 Diabetes diagnosed by doctor 95 Body mass index 0.035843 0.004550 3.316369e-15 0.026899 0.044788 FE IVW HF 0.78
7 Coronary heart disease 974 Body mass index 0.388520 0.049338 3.417302e-15 0.279017 0.498022 FE IVW DF 0.89
UKB-a:488 Medication for cholesterol blood pressure or d... 974 Body mass index 0.061469 0.007819 3.781013e-15 0.039639 0.083300 FE IVW Tophits 0.90
UKB-a:437 Vascular/heart problems diagnosed by doctor: H... 835 Body mass index 0.077617 0.009904 4.607662e-15 0.058206 0.097028 Weighted median HF 0.92
UKB-a:310 Taking other prescription medications 974 Body mass index 0.049055 0.006267 5.002365e-15 0.032166 0.065943 FE IVW DF 0.85
UKB-a:361 Heel bone mineral density (BMD) T-score automa... 2 Body mass index 0.172345 0.022068 5.730365e-15 0.129092 0.215599 FE IVW DF + HF 0.81
UKB-a:216 Illnesses of mother: Diabetes 974 Body mass index 0.027181 0.003481 5.805905e-15 0.020358 0.034004 FE IVW DF + HF 0.85
UKB-a:117 Treatment/medication code: ramipril 2 Body mass index 0.018629 0.002389 6.311165e-15 0.012777 0.024481 FE IVW Tophits 0.84
771 HOMA-IR 2 Body mass index 0.199289 0.020295 6.342266e-15 0.159510 0.239067 Simple mean HF 0.85
109 Waist-to-hip ratio 835 Body mass index 0.331045 0.032470 8.462077e-15 0.267403 0.394686 Simple mean HF 0.90
798 Myocardial infarction 835 Body mass index 0.367509 0.047360 8.501511e-15 0.274683 0.460335 FE IVW DF + HF 0.89
99 Hip circumference 94 Body mass index 0.670147 0.086458 9.110689e-15 0.500692 0.839602 Weighted median DF + HF 0.76
UKB-a:121 Treatment/medication code: simvastatin 974 Body mass index 0.030356 0.003921 9.732121e-15 0.022671 0.038040 FE IVW DF + HF 0.83
UKB-a:285 Arm predicted mass (right) 94 Body mass index 0.249625 0.032295 1.080157e-14 0.186327 0.312923 Simple median DF + HF 0.68
UKB-a:25 Alcohol intake frequency. 2 Body mass index 0.248172 0.032212 1.316264e-14 0.185037 0.311307 Weighted median HF 0.93
50 Hip circumference 785 Body mass index 0.600032 0.030507 1.485554e-14 0.540238 0.659826 Simple mean DF + HF 0.88
UKB-a:121 Treatment/medication code: simvastatin 95 Body mass index 0.038669 0.005054 1.985382e-14 0.028764 0.048575 FE IVW HF 0.81
UKB-a:488 Medication for cholesterol blood pressure or d... 835 Body mass index 0.066628 0.008726 2.254798e-14 0.049524 0.083732 FE IVW DF + HF 0.93
UKB-a:306 Diabetes diagnosed by doctor 974 Body mass index 0.040391 0.003156 2.397091e-14 0.034206 0.046576 Simple mean HF 0.96
107 Weight 785 Body mass index 0.739395 0.046057 2.453305e-14 0.649123 0.829668 Simple mean HF 0.80
UKB-a:450 Medication for cholesterol blood pressure diab... 835 Body mass index 0.055416 0.007273 2.539695e-14 0.040614 0.070218 FE IVW DF + HF 0.86
UKB-a:423 Eye problems/disorders: Diabetes related eye d... 2 Body mass index 0.023954 0.002522 2.842868e-14 0.019011 0.028897 Simple mean HF 0.90
UKB-a:249 Weight 785 Body mass index 0.598569 0.027900 2.858375e-14 0.543885 0.653253 RE IVW HF 0.82
UKB-a:238 Pack years adult smoking as proportion of life... 835 Body mass index 0.171499 0.022572 3.007674e-14 0.110119 0.232879 FE IVW DF 0.81
UKB-a:159 Treatment/medication code: metformin 785 Body mass index 0.032176 0.004236 3.043800e-14 0.023874 0.040478 Simple median Tophits 0.88
919 Phenylalanine 95 Body mass index 0.314637 0.041530 3.562095e-14 0.233237 0.396036 FE IVW DF 0.70
775 Fasting insulin 835 Body mass index 0.150641 0.015299 3.824817e-14 0.120656 0.180627 Simple mean HF 0.92
107 Weight 94 Body mass index 0.666667 0.088112 3.845504e-14 0.493970 0.839363 Simple median DF + HF 0.68
109 Waist-to-hip ratio 95 Body mass index 0.380100 0.050283 4.055348e-14 0.272594 0.487606 FE IVW HF 0.74
98 Hip circumference 94 Body mass index 0.681548 0.090163 4.060933e-14 0.504831 0.858265 Simple median Tophits 0.73
UKB-a:369 Health satisfaction 974 Body mass index 0.142714 0.018966 5.284727e-14 0.104536 0.180893 FE IVW DF 0.91
768 Fasting insulin 974 Body mass index 0.154274 0.020534 5.776699e-14 0.114027 0.194521 FE IVW DF + HF 0.91
UKB-a:252 Long-standing illness disability or infirmity 835 Body mass index 0.059025 0.006008 5.950901e-14 0.047250 0.070800 Simple mean HF 0.97
1034 Height 974 Body mass index 0.483438 0.064618 7.351520e-14 0.312377 0.654500 FE IVW Tophits 0.70
783 Triglycerides 835 Body mass index 0.192852 0.025839 8.422474e-14 0.124017 0.261686 FE IVW Tophits 0.86
108 Waist-to-hip ratio 974 Body mass index 0.442944 0.036347 9.200827e-14 0.371703 0.514184 Simple mean HF 0.85
UKB-a:476 Pain type(s) experienced in last month: Knee pain 835 Body mass index 0.054765 0.005613 9.208796e-14 0.043763 0.065767 Simple mean HF 0.89
476 Butyrylcarnitine 95 Body mass index 0.082442 0.011095 1.081162e-13 0.060696 0.104189 FE IVW Tophits 0.67
UKB-a:22 Number of self-reported non-cancer illnesses 95 Body mass index 0.107776 0.014513 1.120212e-13 0.076433 0.139119 FE IVW HF 0.83
UKB-a:361 Heel bone mineral density (BMD) T-score automa... 835 Body mass index 0.173915 0.023425 1.132975e-13 0.126922 0.220908 FE IVW DF + HF 0.81
UKB-a:294 Wheeze or whistling in the chest in last year 835 Body mass index 0.059245 0.006050 1.428249e-13 0.047387 0.071103 Simple mean HF 0.90
1095 Age at menarche 94 Body mass index -0.517140 0.070330 1.937086e-13 -0.654984 -0.379296 Weighted median DF + HF 0.67
UKB-a:475 Pain type(s) experienced in last month: Hip pain 974 Body mass index 0.026272 0.003578 2.082725e-13 0.019260 0.033285 FE IVW DF + HF 0.94
771 HOMA-IR 974 Body mass index 0.152163 0.020797 2.546462e-13 0.100907 0.203419 FE IVW DF 0.85
UKB-a:488 Medication for cholesterol blood pressure or d... 95 Body mass index 0.083439 0.011408 2.590304e-13 0.060650 0.106229 FE IVW HF 0.71
UKB-a:294 Wheeze or whistling in the chest in last year 785 Body mass index 0.045235 0.006201 2.985978e-13 0.033062 0.057408 FE IVW DF + HF 0.92
UKB-a:237 Pack years of smoking PREVIEW ONLY 835 Body mass index 0.163847 0.022482 3.146598e-13 0.106478 0.221216 FE IVW Tophits 0.83
UKB-a:563 Diagnoses - main ICD10: M17 Gonarthrosis [arth... 2 Body mass index 0.010828 0.001490 3.705426e-13 0.007907 0.013749 FE IVW DF + HF 0.89
863 Glycoprotein acetyls 2 Body mass index 0.298485 0.041096 3.780985e-13 0.217938 0.379033 FE IVW DF + HF 0.77
771 HOMA-IR 835 Body mass index 0.195170 0.021374 3.841285e-13 0.153277 0.237063 Simple mean HF 0.89
UKB-a:208 Illnesses of father: Diabetes 2 Body mass index 0.028172 0.003888 4.288106e-13 0.020552 0.035792 FE IVW HF 0.94
1034 Height 835 Body mass index 0.410977 0.056760 4.466517e-13 0.299727 0.522226 FE IVW DF + HF 0.79
92 Obesity class 3 785 Body mass index 3.650699 0.251588 4.574016e-13 3.157588 4.143811 Simple mean HF 0.82
UKB-a:559 Diagnoses - main ICD10: K80 Cholelithiasis 835 Body mass index 0.013200 0.001465 4.744900e-13 0.010329 0.016071 Simple mean HF 0.90
UKB-a:164 Treatment/medication code: furosemide 2 Body mass index 0.008740 0.001000 5.670145e-13 0.006781 0.010700 Simple mean HF 0.90
77 Waist-to-hip ratio 95 Body mass index 0.418630 0.058195 6.313983e-13 0.304569 0.532691 Penalised median HF 0.78
UKB-a:500 Heel bone mineral density (BMD) T-score automated 94 Body mass index 0.197585 0.027494 6.650719e-13 0.139171 0.256000 FE IVW HF 0.76
UKB-a:251 Overall health rating 835 Body mass index 0.110724 0.015501 9.123057e-13 0.080343 0.141105 Weighted median HF 0.85
783 Triglycerides 2 Body mass index 0.229930 0.024921 9.203782e-13 0.181085 0.278775 RE IVW HF 0.90
1003 Leptin 974 Body mass index 0.354032 0.032489 1.235693e-12 0.290354 0.417710 RE IVW HF 0.86
UKB-a:310 Taking other prescription medications 95 Body mass index 0.056536 0.007972 1.327764e-12 0.040910 0.072162 FE IVW DF 0.89
UKB-a:443 Blood clot DVT bronchitis emphysema asthma rhi... 2 Body mass index 0.010202 0.001442 1.487279e-12 0.007376 0.013027 FE IVW DF + HF 0.83
UKB-a:433 Mouth/teeth dental problems: Dentures 974 Body mass index 0.033374 0.004720 1.536295e-12 0.024123 0.042625 FE IVW HF 0.77
UKB-a:437 Vascular/heart problems diagnosed by doctor: H... 94 Body mass index 0.089185 0.012635 1.683783e-12 0.064421 0.113950 Simple median Tophits 0.74
53 Hip circumference 95 Body mass index 0.538555 0.076430 1.836582e-12 0.388754 0.688355 Penalised median Tophits 0.63
UKB-a:208 Illnesses of father: Diabetes 974 Body mass index 0.032593 0.004627 1.865759e-12 0.023524 0.041661 FE IVW DF + HF 0.87
UKB-a:106 Non-cancer illness code self-reported: osteoar... 94 Body mass index 0.028138 0.004002 2.047874e-12 0.020294 0.035981 FE IVW HF 0.78
UKB-a:476 Pain type(s) experienced in last month: Knee pain 95 Body mass index 0.042714 0.006077 2.081331e-12 0.030803 0.054625 FE IVW HF 0.77
UKB-a:159 Treatment/medication code: metformin 95 Body mass index 0.022801 0.003251 2.309310e-12 0.016142 0.029459 FE IVW HF 0.81
919 Phenylalanine 2 Body mass index 0.275208 0.039397 2.839196e-12 0.197989 0.352426 FE IVW HF 0.83
798 Myocardial infarction 2 Body mass index 0.396230 0.047086 2.842824e-12 0.303941 0.488520 Simple mean HF 0.92
UKB-a:310 Taking other prescription medications 835 Body mass index 0.044016 0.006357 4.381024e-12 0.031557 0.056475 FE IVW DF + HF 0.86
UKB-a:361 Heel bone mineral density (BMD) T-score automa... 974 Body mass index 0.166931 0.024115 4.444676e-12 0.118024 0.215839 FE IVW DF + HF 0.81
UKB-a:269 Impedance of whole body 2 Body mass index -0.553729 0.062332 5.257011e-12 -0.675898 -0.431561 Simple mode DF + HF 0.76
52 Hip circumference 95 Body mass index 0.569228 0.083226 7.945850e-12 0.406107 0.732348 Weighted median Tophits 0.62
109 Waist-to-hip ratio 974 Body mass index 0.343742 0.034036 9.053216e-12 0.277031 0.410453 Simple mean HF 0.82
UKB-a:35 Comparative height size at age 10 974 Body mass index 0.144335 0.011271 1.129210e-11 0.122244 0.166426 RE IVW HF 0.95
UKB-a:513 Usual walking pace 2 Body mass index -0.125056 0.014852 1.216134e-11 -0.154166 -0.095946 Penalised mode DF + HF 0.70
UKB-a:450 Medication for cholesterol blood pressure diab... 974 Body mass index 0.050708 0.007534 1.687891e-11 0.035018 0.066398 FE IVW DF + HF 0.86
UKB-a:271 Impedance of leg (left) 2 Body mass index -0.713440 0.084967 1.727483e-11 -0.879972 -0.546908 Simple mode DF + HF 0.65
302 Triglycerides 94 Body mass index 0.173485 0.025795 1.748902e-11 0.120932 0.226037 FE IVW HF 0.77
897 Leucine 2 Body mass index 0.232107 0.034644 2.086500e-11 0.164206 0.300009 FE IVW DF + HF 0.86
UKB-a:369 Health satisfaction 2 Body mass index 0.139973 0.017516 2.275999e-11 0.105641 0.174305 Simple mean DF + HF 0.82
UKB-a:563 Diagnoses - main ICD10: M17 Gonarthrosis [arth... 835 Body mass index 0.011324 0.001694 2.292124e-11 0.008004 0.014643 FE IVW DF + HF 0.90
UKB-a:23 Number of operations self-reported 835 Body mass index 0.065255 0.009781 2.531919e-11 0.039347 0.091163 FE IVW Tophits 0.78
UKB-a:132 Treatment/medication code: aspirin 2 Body mass index 0.025493 0.003822 2.548112e-11 0.014542 0.036445 FE IVW Tophits 0.92
UKB-a:513 Usual walking pace 94 Body mass index -0.116854 0.017539 2.694100e-11 -0.151230 -0.082477 Weighted median DF + HF 0.64
UKB-a:71 Non-cancer illness code self-reported: choleli... 974 Body mass index 0.008744 0.001314 2.797051e-11 0.006169 0.011318 FE IVW DF + HF 0.84
UKB-a:32 Alcohol intake versus 10 years previously 2 Body mass index 0.057076 0.008579 2.866916e-11 0.032845 0.081306 FE IVW Tophits 0.78
UKB-a:61 Non-cancer illness code self-reported: hyperte... 974 Body mass index 0.069963 0.006227 2.904512e-11 0.057759 0.082168 RE IVW HF 0.92
91 Obesity class 2 785 Body mass index 1.936937 0.291333 2.960161e-11 1.365935 2.507939 Simple median DF + HF 0.90
UKB-a:270 Impedance of leg (right) 2 Body mass index -0.618413 0.074830 4.244612e-11 -0.765078 -0.471748 Simple mode DF + HF 0.66
775 Fasting insulin 974 Body mass index 0.140534 0.014627 4.364943e-11 0.111865 0.169202 Simple mean HF 0.87
75 Waist-to-hip ratio 94 Body mass index 0.337719 0.051338 4.757966e-11 0.237098 0.438340 Simple median Tophits 0.69
UKB-a:35 Comparative height size at age 10 95 Body mass index 0.118703 0.018120 5.715916e-11 0.083188 0.154217 Weighted median DF + HF 0.73
UKB-a:222 Illnesses of siblings: High blood pressure 974 Body mass index 0.046335 0.004910 6.782913e-11 0.036711 0.055959 Simple mean HF 0.93
UKB-a:44 Townsend deprivation index at recruitment 835 Body mass index 0.079045 0.012130 7.196498e-11 0.045158 0.112932 FE IVW DF 0.79
UKB-a:476 Pain type(s) experienced in last month: Knee pain 974 Body mass index 0.052106 0.005613 7.582779e-11 0.041103 0.063108 Simple mean HF 0.90
1037 Difference in height between childhood and adu... 785 Body mass index -0.520875 0.080135 8.034038e-11 -0.731812 -0.309938 FE IVW Tophits 0.71
1034 Height 2 Body mass index 0.356558 0.055004 9.023411e-11 0.248752 0.464365 FE IVW DF + HF 0.78
UKB-a:294 Wheeze or whistling in the chest in last year 2 Body mass index 0.052605 0.008118 9.166369e-11 0.036694 0.068515 Simple median DF 0.89
302 Triglycerides 785 Body mass index 0.211113 0.019410 9.298377e-11 0.173069 0.249158 Simple mean DF + HF 0.87
UKB-a:381 Leg pain on walking 835 Body mass index 0.054306 0.008415 1.094307e-10 0.037812 0.070800 FE IVW DF + HF 0.86
1003 Leptin 95 Body mass index 0.402718 0.062415 1.101716e-10 0.280388 0.525049 Weighted median DF + HF 0.78
873 Isoleucine 2 Body mass index 0.238703 0.037096 1.237252e-10 0.165994 0.311412 FE IVW DF + HF 0.79
UKB-a:35 Comparative height size at age 10 94 Body mass index 0.113323 0.017614 1.245199e-10 0.078801 0.147846 Weighted median Tophits 0.70
UKB-a:359 Diastolic blood pressure automated reading 974 Body mass index 0.100407 0.015617 1.282585e-10 0.066646 0.134168 FE IVW HF 0.78
UKB-a:193 Treatment/medication code: bendroflumethiazide 2 Body mass index 0.018073 0.002814 1.332343e-10 0.012558 0.023587 FE IVW DF + HF 0.88
UKB-a:504 Job involves shift work 835 Body mass index 0.103641 0.013401 1.393706e-10 0.077376 0.129906 Simple mean HF 0.82
UKB-a:380 Shortness of breath walking on level ground 2 Body mass index 0.044671 0.005957 1.415106e-10 0.032995 0.056346 RE IVW DF + HF 0.78
UKB-a:193 Treatment/medication code: bendroflumethiazide 974 Body mass index 0.018142 0.002839 1.654117e-10 0.012578 0.023706 FE IVW DF + HF 0.87
UKB-a:289 Arm predicted mass (left) 785 Body mass index 0.333875 0.020579 1.795144e-10 0.293540 0.374210 Simple mean HF 0.76
UKB-a:75 Non-cancer illness code self-reported: type 2 ... 835 Body mass index 0.008454 0.001107 1.830596e-10 0.006285 0.010623 Simple mean DF + HF 0.83
UKB-a:381 Leg pain on walking 95 Body mass index 0.068023 0.010671 1.831539e-10 0.047109 0.088937 FE IVW DF 0.83
UKB-a:48 Sensitivity / hurt feelings 95 Body mass index 0.042475 0.006671 1.924442e-10 0.029400 0.055550 FE IVW HF 0.76
UKB-a:284 Arm fat-free mass (right) 785 Body mass index 0.304983 0.019071 2.174769e-10 0.267604 0.342362 Simple mean HF 0.73
UKB-a:369 Health satisfaction 835 Body mass index 0.136580 0.017931 2.209269e-10 0.101436 0.171725 RE IVW HF 0.85
UKB-a:423 Eye problems/disorders: Diabetes related eye d... 94 Body mass index 0.024747 0.003902 2.264979e-10 0.017099 0.032394 FE IVW HF 0.78
UKB-a:309 Other serious medical condition/disability dia... 835 Body mass index 0.030396 0.004033 2.299386e-10 0.022492 0.038301 Simple mean HF 0.90
UKB-a:490 Medication for cholesterol blood pressure or d... 785 Body mass index 0.095635 0.008813 2.676061e-10 0.078361 0.112909 Simple mean HF 0.84
UKB-a:117 Treatment/medication code: ramipril 835 Body mass index 0.016623 0.002635 2.805859e-10 0.009746 0.023499 FE IVW DF 0.79
UKB-a:559 Diagnoses - main ICD10: K80 Cholelithiasis 785 Body mass index 0.010680 0.001693 2.843698e-10 0.007361 0.013999 FE IVW DF + HF 0.84
UKB-a:361 Heel bone mineral density (BMD) T-score automa... 95 Body mass index 0.249303 0.039563 2.950305e-10 0.171760 0.326845 Penalised median DF 0.75
UKB-a:437 Vascular/heart problems diagnosed by doctor: H... 785 Body mass index 0.084686 0.006591 3.516833e-10 0.071767 0.097606 RE IVW HF 0.84
102 Waist circumference 94 Body mass index 0.867760 0.030544 4.035335e-10 0.807894 0.927626 RE IVW HF 0.71
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks 2 Body mass index 0.064091 0.010259 4.177893e-10 0.043579 0.084602 FE IVW HF 0.85
UKB-a:222 Illnesses of siblings: High blood pressure 785 Body mass index 0.061841 0.009902 4.234363e-10 0.042433 0.081249 Penalised median DF 0.85
UKB-a:270 Impedance of leg (right) 835 Body mass index -0.586655 0.093981 4.312011e-10 -0.790899 -0.382412 FE Egger HF 0.69
775 Fasting insulin 95 Body mass index 0.183655 0.029426 4.338068e-10 0.125982 0.241328 Weighted median DF + HF 0.75
UKB-a:65 Non-cancer illness code self-reported: deep ve... 785 Body mass index 0.008877 0.001422 4.362156e-10 0.006089 0.011664 FE IVW DF + HF 0.87
UKB-a:63 Non-cancer illness code self-reported: heart a... 2 Body mass index 0.010375 0.001663 4.425449e-10 0.007115 0.013634 FE IVW DF + HF 0.92
UKB-a:34 Comparative body size at age 10 785 Body mass index 0.330441 0.021800 4.429552e-10 0.287714 0.373168 RE IVW DF + HF 0.83
UKB-a:362 Heel bone mineral density (BMD) T-score automa... 974 Body mass index 0.152393 0.024436 4.476041e-10 0.101037 0.203749 FE IVW DF + HF 0.78
UKB-a:71 Non-cancer illness code self-reported: choleli... 2 Body mass index 0.008867 0.001423 4.591740e-10 0.006078 0.011655 FE IVW Tophits 0.77
103 Waist circumference 95 Body mass index 0.808001 0.034553 4.632560e-10 0.740276 0.875726 RE IVW HF 0.76
UKB-a:452 Medication for pain relief constipation heartb... 2 Body mass index 0.029719 0.004092 5.942029e-10 0.021699 0.037739 RE IVW DF + HF 0.95
798 Myocardial infarction 974 Body mass index 0.404068 0.046554 6.427648e-10 0.312823 0.495313 RE IVW HF 0.94
UKB-a:381 Leg pain on walking 2 Body mass index 0.056923 0.007978 7.084331e-10 0.041286 0.072560 Simple mean HF 0.90
UKB-a:361 Heel bone mineral density (BMD) T-score automa... 94 Body mass index 0.191038 0.031017 7.316065e-10 0.118641 0.263435 FE IVW DF + HF 0.70
UKB-a:25 Alcohol intake frequency. 835 Body mass index 0.191386 0.031187 8.428708e-10 0.130260 0.252513 Simple median Tophits 0.88
UKB-a:262 Falls in the last year 2 Body mass index 0.039308 0.006407 8.513451e-10 0.021335 0.057280 FE IVW DF 0.74
UKB-a:273 Impedance of arm (left) 835 Body mass index -0.436771 0.060916 8.678259e-10 -0.556164 -0.317378 Simple mode DF 0.72
UKB-a:434 Vascular/heart problems diagnosed by doctor: H... 2 Body mass index 0.010265 0.001680 1.002469e-09 0.006972 0.013559 FE IVW DF + HF 0.88
UKB-a:71 Non-cancer illness code self-reported: choleli... 835 Body mass index 0.010273 0.001438 1.131844e-09 0.007453 0.013092 RE IVW HF 0.78
UKB-a:528 Diagnoses - main ICD10: G56 Mononeuropathies o... 94 Body mass index 0.013658 0.002245 1.163853e-09 0.009259 0.018058 FE IVW HF 0.76
UKB-a:452 Medication for pain relief constipation heartb... 835 Body mass index 0.027204 0.004472 1.175629e-09 0.018439 0.035969 FE IVW DF + HF 0.89
UKB-a:22 Number of self-reported non-cancer illnesses 94 Body mass index 0.086837 0.014283 1.205196e-09 0.058841 0.114833 FE IVW HF 0.74
99 Hip circumference 95 Body mass index 0.785044 0.037176 1.260788e-09 0.712179 0.857909 Simple mean DF + HF 0.79
768 Fasting insulin 95 Body mass index 0.162410 0.026761 1.287107e-09 0.093870 0.230950 FE IVW DF 0.77
UKB-a:28 Average weekly beer plus cider intake 94 Body mass index -0.128175 0.021155 1.370403e-09 -0.169637 -0.086712 Penalised median DF 0.75
UKB-a:504 Job involves shift work 974 Body mass index 0.087192 0.014471 1.687745e-09 0.058291 0.116093 FE IVW DF + HF 0.87
UKB-a:491 Medication for cholesterol blood pressure or d... 2 Body mass index 0.011522 0.001917 1.845762e-09 0.007765 0.015279 FE IVW DF 0.82
775 Fasting insulin 785 Body mass index 0.164119 0.017956 1.905405e-09 0.128925 0.199312 Simple mean HF 0.95
1032 Height 835 Body mass index 0.602194 0.084441 1.920612e-09 0.436690 0.767697 Simple mean HF 0.77
UKB-a:227 Alcohol drinker status: Previous 835 Body mass index 0.013630 0.002273 2.032183e-09 0.008359 0.018901 FE IVW DF 0.81
UKB-a:106 Non-cancer illness code self-reported: osteoar... 974 Body mass index 0.029094 0.003458 2.168856e-09 0.022317 0.035872 Simple mean HF 0.92
UKB-a:238 Pack years adult smoking as proportion of life... 2 Body mass index 0.139221 0.020096 2.326205e-09 0.099833 0.178609 Simple mean HF 0.81
UKB-a:223 Illnesses of siblings: Diabetes 974 Body mass index 0.034712 0.004238 2.350633e-09 0.026405 0.043018 Simple mean HF 0.89
1035 Difference in height between childhood and adu... 95 Body mass index -0.476609 0.079850 2.389944e-09 -0.633115 -0.320103 FE IVW HF 0.68
UKB-a:223 Illnesses of siblings: Diabetes 785 Body mass index 0.038857 0.006517 2.491080e-09 0.026083 0.051631 Penalised median HF 0.89
UKB-a:491 Medication for cholesterol blood pressure or d... 835 Body mass index 0.011976 0.002017 2.917518e-09 0.008022 0.015930 FE IVW Tophits 0.84
UKB-a:22 Number of self-reported non-cancer illnesses 974 Body mass index 0.088849 0.010970 3.005147e-09 0.067347 0.110351 RE IVW HF 0.87
75 Waist-to-hip ratio 785 Body mass index 0.317600 0.034284 3.170291e-09 0.250404 0.384796 Simple mean DF + HF 0.85
UKB-a:488 Medication for cholesterol blood pressure or d... 94 Body mass index 0.091733 0.015555 3.692847e-09 0.061246 0.122220 Penalised median HF 0.83
UKB-a:108 Non-cancer illness code self-reported: high ch... 2 Body mass index 0.021804 0.003698 3.711042e-09 0.008986 0.034623 FE IVW Tophits 0.90
UKB-a:381 Leg pain on walking 974 Body mass index 0.062064 0.007827 3.823294e-09 0.046722 0.077406 RE IVW HF 0.91
UKB-a:176 Treatment/medication code: atorvastatin 2 Body mass index 0.012793 0.001890 3.897541e-09 0.009090 0.016497 RE IVW HF 0.86
UKB-a:300 Relative age voice broke 835 Body mass index -0.063415 0.009392 4.203234e-09 -0.081824 -0.045006 Simple mean DF 0.69
UKB-a:149 Treatment/medication code: doxazosin 785 Body mass index 0.007119 0.001212 4.246487e-09 0.004743 0.009494 FE IVW DF + HF 0.75
870 Concentration of IDL particles 95 Body mass index 0.195220 0.033251 4.329931e-09 0.130048 0.260392 FE IVW DF + HF 0.67
302 Triglycerides 95 Body mass index 0.207427 0.035431 4.787441e-09 0.137984 0.276871 Weighted median HF 0.77
UKB-a:62 Non-cancer illness code self-reported: angina 835 Body mass index 0.012386 0.002117 4.880228e-09 0.008237 0.016536 FE IVW DF + HF 0.88
UKB-a:223 Illnesses of siblings: Diabetes 95 Body mass index 0.044321 0.007576 4.911979e-09 0.029472 0.059170 Weighted median HF 0.80
UKB-a:446 Blood clot DVT bronchitis emphysema asthma rhi... 95 Body mass index 0.020623 0.003533 5.322126e-09 0.013698 0.027548 FE IVW DF 0.76
UKB-a:252 Long-standing illness disability or infirmity 785 Body mass index 0.065090 0.007382 5.409125e-09 0.050621 0.079559 Simple mean DF + HF 0.89
UKB-a:24 Number of treatments/medications taken 94 Body mass index 0.120801 0.020715 5.488010e-09 0.080201 0.161401 Weighted median DF + HF 0.79
UKB-a:443 Blood clot DVT bronchitis emphysema asthma rhi... 785 Body mass index 0.011326 0.001335 5.793800e-09 0.008709 0.013944 Simple mean HF 0.88
UKB-a:272 Impedance of arm (right) 835 Body mass index -0.292320 0.041058 6.028590e-09 -0.372792 -0.211848 Penalised mode DF + HF 0.75
UKB-a:436 Vascular/heart problems diagnosed by doctor: A... 2 Body mass index 0.012350 0.002140 7.923303e-09 0.008155 0.016545 FE IVW DF + HF 0.84
UKB-a:380 Shortness of breath walking on level ground 835 Body mass index 0.042381 0.006283 8.436587e-09 0.030067 0.054695 Simple mean DF + HF 0.82
UKB-a:269 Impedance of whole body 835 Body mass index -0.374075 0.053344 8.728213e-09 -0.478628 -0.269522 Penalised mode DF + HF 0.70
UKB-a:504 Job involves shift work 2 Body mass index 0.071528 0.012437 8.860508e-09 0.041850 0.101205 FE IVW Tophits 0.84
UKB-a:121 Treatment/medication code: simvastatin 94 Body mass index 0.043692 0.007609 9.333582e-09 0.028779 0.058605 Penalised median HF 0.88
UKB-a:362 Heel bone mineral density (BMD) T-score automa... 2 Body mass index 0.145354 0.022046 9.568543e-09 0.102144 0.188563 RE IVW HF 0.85
1095 Age at menarche 2 Body mass index -0.525306 0.079367 1.043425e-08 -0.680863 -0.369749 Penalised mode DF + HF 0.71
938 Tyrosine 974 Body mass index 0.234649 0.040999 1.044850e-08 0.154291 0.315008 FE IVW DF 0.83
UKB-a:75 Non-cancer illness code self-reported: type 2 ... 2 Body mass index 0.008586 0.001503 1.101224e-08 0.005641 0.011531 Penalised median DF 0.82
UKB-a:423 Eye problems/disorders: Diabetes related eye d... 974 Body mass index 0.020544 0.002746 1.104643e-08 0.015162 0.025925 Simple mean HF 0.92
UKB-a:116 Treatment/medication code: lisinopril 2 Body mass index 0.010627 0.001861 1.118145e-08 0.005840 0.015415 FE IVW Tophits 0.74
UKB-a:39 Maternal smoking around birth 835 Body mass index 0.035305 0.006184 1.138182e-08 0.018379 0.052232 FE IVW DF 0.76
UKB-a:121 Treatment/medication code: simvastatin 835 Body mass index 0.034078 0.005975 1.170888e-08 0.022369 0.045788 Weighted median HF 0.89
UKB-a:106 Non-cancer illness code self-reported: osteoar... 2 Body mass index 0.027151 0.004772 1.274233e-08 0.017798 0.036504 Simple median DF + HF 0.88
1033 Height 835 Body mass index 0.519310 0.091456 1.360897e-08 0.291141 0.747479 FE IVW Tophits 0.78
UKB-a:22 Number of self-reported non-cancer illnesses 785 Body mass index 0.108756 0.019180 1.425489e-08 0.071164 0.146347 Penalised median HF 0.87
914 Phospholipids in medium VLDL 2 Body mass index 0.230231 0.040726 1.574875e-08 0.150409 0.310054 FE IVW DF + HF 0.78
UKB-a:560 Diagnoses - main ICD10: L03 Cellulitis 2 Body mass index 0.005663 0.000890 1.633935e-08 0.003918 0.007408 Simple mean DF + HF 0.82
UKB-a:252 Long-standing illness disability or infirmity 95 Body mass index 0.066036 0.011698 1.650057e-08 0.043109 0.088964 Penalised median HF 0.88
873 Isoleucine 785 Body mass index 0.218439 0.038729 1.698034e-08 0.142531 0.294347 FE IVW DF + HF 0.76
UKB-a:39 Maternal smoking around birth 2 Body mass index 0.039437 0.006197 2.048572e-08 0.027290 0.051583 Simple mean HF 0.80
UKB-a:359 Diastolic blood pressure automated reading 835 Body mass index 0.130666 0.023310 2.077134e-08 0.084978 0.176353 Weighted median HF 0.88
773 Fasting glucose 785 Body mass index 0.080650 0.014425 2.256995e-08 0.052378 0.108923 FE IVW DF + HF 0.86
UKB-a:223 Illnesses of siblings: Diabetes 94 Body mass index 0.043497 0.007780 2.259534e-08 0.028249 0.058746 Penalised median HF 0.75
UKB-a:139 Treatment/medication code: gliclazide 785 Body mass index 0.010746 0.001922 2.271162e-08 0.006978 0.014514 Simple median Tophits 0.86
940 Valine 785 Body mass index 0.234862 0.042053 2.337958e-08 0.152439 0.317286 FE IVW DF + HF 0.79
UKB-a:251 Overall health rating 94 Body mass index 0.103891 0.018624 2.428028e-08 0.067389 0.140394 Penalised median HF 0.82
UKB-a:537 Diagnoses - main ICD10: I80 Phlebitis and thro... 2 Body mass index 0.003465 0.000621 2.464091e-08 0.002247 0.004683 FE IVW DF + HF 0.89
UKB-a:436 Vascular/heart problems diagnosed by doctor: A... 835 Body mass index 0.013678 0.002134 2.512443e-08 0.009496 0.017860 RE IVW HF 0.86
UKB-a:153 Treatment/medication code: insulin product 95 Body mass index 0.008504 0.001527 2.574457e-08 0.005511 0.011497 FE IVW DF 0.77
UKB-a:69 Non-cancer illness code self-reported: sleep a... 835 Body mass index 0.003016 0.000542 2.642282e-08 0.001954 0.004079 FE IVW DF + HF 0.88
UKB-a:217 Illnesses of siblings: Heart disease 95 Body mass index 0.024593 0.004426 2.747429e-08 0.015918 0.033267 FE IVW HF 0.81
UKB-a:77 Non-cancer illness code self-reported: hypothy... 2 Body mass index 0.013331 0.002408 3.108264e-08 0.007142 0.019520 FE IVW Tophits 0.74
UKB-a:131 Treatment/medication code: atenolol 94 Body mass index 0.014216 0.002586 3.855936e-08 0.009148 0.019285 FE IVW HF 0.73
770 HOMA-B 974 Body mass index 0.093628 0.017081 4.215833e-08 0.056118 0.131138 FE IVW DF 0.80
UKB-a:381 Leg pain on walking 785 Body mass index 0.054632 0.009972 4.291624e-08 0.026807 0.082458 FE IVW DF 0.77
UKB-a:222 Illnesses of siblings: High blood pressure 94 Body mass index 0.058848 0.010775 4.714518e-08 0.037730 0.079965 Penalised median DF 0.79
7 Coronary heart disease 2 Body mass index 0.397101 0.072745 4.793827e-08 0.254523 0.539680 Simple median HF 0.92
UKB-a:162 Treatment/medication code: perindopril 2 Body mass index 0.007327 0.001342 4.796732e-08 0.004414 0.010241 FE IVW Tophits 0.76
1033 Height 2 Body mass index 0.350794 0.064301 4.884001e-08 0.224764 0.476824 FE IVW DF 0.73
UKB-a:25 Alcohol intake frequency. 785 Body mass index 0.240872 0.044182 4.986787e-08 0.154276 0.327467 Weighted median HF 0.76
770 HOMA-B 785 Body mass index 0.106513 0.019549 5.082011e-08 0.059860 0.153166 FE IVW DF 0.81
UKB-a:172 Treatment/medication code: co-codamol 2 Body mass index 0.009275 0.001707 5.487035e-08 0.005165 0.013385 FE IVW Tophits 0.78
UKB-a:237 Pack years of smoking PREVIEW ONLY 974 Body mass index 0.121403 0.022346 5.543305e-08 0.050188 0.192617 FE IVW DF 0.75
UKB-a:286 Arm fat percentage (left) 94 Body mass index 0.472522 0.024572 5.544973e-08 0.424361 0.520683 RE IVW DF + HF 0.70
299 HDL cholesterol 94 Body mass index -0.204876 0.037756 5.751456e-08 -0.278875 -0.130876 Weighted median DF + HF 0.73
UKB-a:208 Illnesses of father: Diabetes 785 Body mass index 0.037257 0.006874 5.960060e-08 0.023784 0.050730 Penalised median DF 0.93
UKB-a:513 Usual walking pace 785 Body mass index -0.123577 0.022838 6.266807e-08 -0.168340 -0.078815 FE Egger HF 0.74
UKB-a:149 Treatment/medication code: doxazosin 94 Body mass index 0.007705 0.001425 6.432328e-08 0.004911 0.010498 FE IVW HF 0.76
UKB-a:559 Diagnoses - main ICD10: K80 Cholelithiasis 974 Body mass index 0.010538 0.001534 6.579334e-08 0.007531 0.013546 Simple mean HF 0.90
UKB-a:65 Non-cancer illness code self-reported: deep ve... 2 Body mass index 0.008662 0.001448 6.942882e-08 0.005825 0.011500 RE IVW HF 0.79
UKB-a:117 Treatment/medication code: ramipril 974 Body mass index 0.018016 0.002631 6.976321e-08 0.012859 0.023172 RE IVW HF 0.78
UKB-a:227 Alcohol drinker status: Previous 95 Body mass index 0.013901 0.002578 6.992427e-08 0.008847 0.018954 FE IVW HF 0.76
UKB-a:150 Treatment/medication code: amlodipine 974 Body mass index 0.016311 0.002326 7.155432e-08 0.011752 0.020870 Simple mean HF 0.85
950 Concentration of very large VLDL particles 2 Body mass index 0.279531 0.046645 7.184947e-08 0.188108 0.370954 Simple mean HF 0.72
UKB-a:278 Leg fat percentage (left) 94 Body mass index 0.345193 0.014995 7.398837e-08 0.315803 0.374582 RE IVW DF + HF 0.72
UKB-a:63 Non-cancer illness code self-reported: heart a... 835 Body mass index 0.009979 0.001860 8.153030e-08 0.005515 0.014443 FE IVW DF 0.79
919 Phenylalanine 974 Body mass index 0.235283 0.043994 8.889055e-08 0.149055 0.321511 FE IVW DF + HF 0.77
873 Isoleucine 974 Body mass index 0.258000 0.038490 9.264184e-08 0.182560 0.333441 Simple mean HF 0.88
UKB-a:362 Heel bone mineral density (BMD) T-score automa... 835 Body mass index 0.112953 0.021196 9.874285e-08 0.041647 0.184259 FE IVW Tophits 0.82
77 Waist-to-hip ratio 94 Body mass index 0.494947 0.032567 1.006846e-07 0.431115 0.558779 RE IVW HF 0.75
940 Valine 2 Body mass index 0.213921 0.040206 1.034290e-07 0.135117 0.292726 FE IVW DF 0.77
UKB-a:149 Treatment/medication code: doxazosin 2 Body mass index 0.006344 0.001194 1.067037e-07 0.003968 0.008720 FE IVW DF 0.77
775 Fasting insulin 94 Body mass index 0.172965 0.032548 1.071164e-07 0.109173 0.236758 Penalised median DF 0.67
299 HDL cholesterol 95 Body mass index -0.191858 0.036148 1.110713e-07 -0.262707 -0.121010 Weighted median DF + HF 0.77
1095 Age at menarche 835 Body mass index -0.881425 0.166203 1.137274e-07 -1.207182 -0.555667 FE Egger HF 0.68
UKB-a:293 Trunk predicted mass 785 Body mass index 0.309817 0.044441 1.154211e-07 0.222715 0.396920 Simple mode Tophits 0.69
UKB-a:382 Waist circumference 95 Body mass index 0.522344 0.029929 1.185250e-07 0.463682 0.581005 RE IVW DF + HF 0.70
UKB-a:563 Diagnoses - main ICD10: M17 Gonarthrosis [arth... 974 Body mass index 0.008672 0.001639 1.208788e-07 0.005460 0.011883 FE IVW HF 0.79
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic ... 2 Body mass index 0.009694 0.001833 1.231921e-07 0.006089 0.013299 FE IVW DF + HF 0.90
892 Triglycerides in large VLDL 974 Body mass index 0.256783 0.048572 1.245720e-07 0.161582 0.351984 FE IVW DF 0.81
UKB-a:24 Number of treatments/medications taken 974 Body mass index 0.091411 0.017306 1.277665e-07 0.057492 0.125330 Simple median Tophits 0.89
798 Myocardial infarction 95 Body mass index 0.358480 0.067947 1.321243e-07 0.225304 0.491656 FE IVW HF 0.77
897 Leucine 95 Body mass index 0.221035 0.041906 1.331172e-07 0.138899 0.303172 FE IVW DF 0.72
70 Waist circumference 2 Body mass index 0.113151 0.021490 1.400023e-07 0.071030 0.155271 FE IVW DF + HF 0.88
UKB-a:131 Treatment/medication code: atenolol 2 Body mass index 0.011494 0.002190 1.543231e-07 0.005521 0.017466 FE IVW DF 0.79
66 Waist circumference 2 Body mass index 0.084620 0.014444 1.560625e-07 0.056310 0.112931 Simple mean DF + HF 0.92
UKB-a:217 Illnesses of siblings: Heart disease 2 Body mass index 0.019789 0.003777 1.616401e-07 0.011198 0.028380 FE IVW Tophits 0.77
UKB-a:150 Treatment/medication code: amlodipine 835 Body mass index 0.012886 0.002461 1.631878e-07 0.007121 0.018651 FE IVW DF 0.88
UKB-a:274 Leg fat percentage (right) 94 Body mass index 0.345681 0.016842 1.635343e-07 0.312670 0.378692 RE IVW DF + HF 0.73
UKB-a:106 Non-cancer illness code self-reported: osteoar... 95 Body mass index 0.034221 0.006542 1.685142e-07 0.021399 0.047043 Simple median Tophits 0.81
UKB-a:292 Trunk fat-free mass 785 Body mass index 0.310995 0.045571 1.707040e-07 0.221678 0.400312 Simple mode Tophits 0.71
UKB-a:491 Medication for cholesterol blood pressure or d... 974 Body mass index 0.010920 0.002092 1.798250e-07 0.006819 0.015021 FE IVW Tophits 0.79
UKB-a:256 Other eye problems 95 Body mass index 0.018236 0.003496 1.818208e-07 0.011385 0.025088 FE IVW HF 0.83
UKB-a:116 Treatment/medication code: lisinopril 974 Body mass index 0.011050 0.002120 1.876066e-07 0.006723 0.015376 FE IVW DF + HF 0.77
UKB-a:262 Falls in the last year 835 Body mass index 0.036789 0.007070 1.955955e-07 0.016975 0.056604 FE IVW DF 0.73
UKB-a:150 Treatment/medication code: amlodipine 95 Body mass index 0.016980 0.003265 1.977598e-07 0.010559 0.023402 FE IVW HF 0.78
UKB-a:190 Treatment/medication code: levothyroxine sodium 2 Body mass index 0.013147 0.002272 1.994477e-07 0.008694 0.017600 RE IVW HF 0.76
UKB-a:61 Non-cancer illness code self-reported: hyperte... 95 Body mass index 0.066604 0.012812 2.007047e-07 0.041493 0.091714 Penalised median DF 0.71
UKB-a:245 Frequency of tiredness / lethargy in last 2 weeks 835 Body mass index 0.067934 0.011455 2.082635e-07 0.045482 0.090386 RE IVW DF + HF 0.84
892 Triglycerides in large VLDL 2 Body mass index 0.200127 0.038656 2.253821e-07 0.124360 0.275893 FE IVW DF 0.76
64 Waist circumference 94 Body mass index 0.744632 0.046435 2.293730e-07 0.653619 0.835644 Simple mean DF + HF 0.69
108 Waist-to-hip ratio 95 Body mass index 0.463415 0.089781 2.448357e-07 0.287447 0.639382 Simple median Tophits 0.76
UKB-a:491 Medication for cholesterol blood pressure or d... 94 Body mass index 0.011922 0.002311 2.489796e-07 0.007392 0.016451 FE IVW HF 0.77
768 Fasting insulin 785 Body mass index 0.184307 0.035746 2.522595e-07 0.114246 0.254368 Weighted median DF + HF 0.90
UKB-a:227 Alcohol drinker status: Previous 2 Body mass index 0.012554 0.002205 2.604480e-07 0.008232 0.016875 Simple mean DF + HF 0.81
UKB-a:215 Illnesses of mother: High blood pressure 835 Body mass index 0.030590 0.005949 2.715561e-07 0.016638 0.044541 FE IVW DF 0.72
UKB-a:184 Treatment/medication code: rosiglitazone 95 Body mass index 0.002957 0.000576 2.877780e-07 0.001827 0.004086 FE IVW HF 0.81
UKB-a:75 Non-cancer illness code self-reported: type 2 ... 785 Body mass index 0.006821 0.001331 2.967282e-07 0.003996 0.009646 FE IVW HF 0.79
UKB-a:106 Non-cancer illness code self-reported: osteoar... 835 Body mass index 0.027597 0.005388 3.021427e-07 0.017037 0.038156 Weighted median HF 0.89
UKB-a:65 Non-cancer illness code self-reported: deep ve... 835 Body mass index 0.008974 0.001752 3.023367e-07 0.005480 0.012469 FE IVW DF 0.76
UKB-a:475 Pain type(s) experienced in last month: Hip pain 785 Body mass index 0.033364 0.004828 3.037905e-07 0.023902 0.042826 Simple mean HF 0.90
UKB-a:190 Treatment/medication code: levothyroxine sodium 835 Body mass index 0.014340 0.002485 3.094943e-07 0.009470 0.019211 Simple mean HF 0.79
72 Waist-to-hip ratio 94 Body mass index 0.393453 0.025554 3.146583e-07 0.343367 0.443539 RE IVW HF 0.73
940 Valine 835 Body mass index 0.235029 0.046035 3.300969e-07 0.144800 0.325258 FE IVW HF 0.74
UKB-a:77 Non-cancer illness code self-reported: hypothy... 835 Body mass index 0.013571 0.002659 3.330923e-07 0.006737 0.020405 FE IVW DF 0.74
UKB-a:222 Illnesses of siblings: High blood pressure 95 Body mass index 0.053211 0.010437 3.427207e-07 0.032755 0.073668 Penalised median DF 0.81
1033 Height 974 Body mass index 0.460904 0.090543 3.572283e-07 0.218004 0.703803 FE IVW Tophits 0.75
UKB-a:448 Medication for cholesterol blood pressure diab... 2 Body mass index 0.029532 0.005206 3.645432e-07 0.019328 0.039735 RE IVW DF + HF 0.84
891 Phospholipids in large VLDL 974 Body mass index 0.225887 0.044438 3.712334e-07 0.138787 0.312986 FE IVW DF 0.80
85 Extreme body mass index 835 Body mass index 2.199342 0.121329 3.845852e-07 1.961537 2.437147 RE IVW DF 0.83
1032 Height 974 Body mass index 0.351165 0.069208 3.894690e-07 0.215517 0.486813 FE IVW DF + HF 0.79
915 Triglycerides in medium VLDL 2 Body mass index 0.207396 0.040875 3.897384e-07 0.127281 0.287512 FE IVW DF 0.77
UKB-a:142 Treatment/medication code: allopurinol 2 Body mass index 0.006040 0.001191 3.946515e-07 0.003288 0.008793 FE IVW Tophits 0.76
897 Leucine 974 Body mass index 0.232107 0.045788 3.996136e-07 0.142362 0.321852 FE IVW DF 0.81
UKB-a:142 Treatment/medication code: allopurinol 974 Body mass index 0.006646 0.001312 4.085098e-07 0.003410 0.009882 FE IVW DF 0.80
UKB-a:528 Diagnoses - main ICD10: G56 Mononeuropathies o... 95 Body mass index 0.015950 0.003158 4.388443e-07 0.009761 0.022139 Penalised median DF 0.78
UKB-a:62 Non-cancer illness code self-reported: angina 2 Body mass index 0.009916 0.001968 4.686446e-07 0.004769 0.015062 FE IVW DF 0.83
757 Fasting glucose 2 Body mass index 0.085036 0.016883 4.734053e-07 0.051945 0.118126 FE IVW HF 0.72
783 Triglycerides 785 Body mass index 0.232807 0.046358 5.113873e-07 0.141948 0.323666 Penalised median DF 0.79
UKB-a:20 Exposure to tobacco smoke outside home 835 Body mass index 0.038649 0.006894 5.298733e-07 0.025137 0.052161 Simple mean HF 0.80
UKB-a:560 Diagnoses - main ICD10: L03 Cellulitis 94 Body mass index 0.006086 0.001215 5.455432e-07 0.003705 0.008467 FE IVW HF 0.81
UKB-a:513 Usual walking pace 835 Body mass index -0.126638 0.021917 5.461508e-07 -0.169594 -0.083682 Penalised mode DF + HF 0.70
915 Triglycerides in medium VLDL 974 Body mass index 0.257143 0.051380 5.595278e-07 0.150214 0.364072 FE IVW DF 0.82
UKB-a:75 Non-cancer illness code self-reported: type 2 ... 974 Body mass index 0.006264 0.001013 5.662528e-07 0.004278 0.008251 RE IVW HF 0.82
61 Waist circumference 94 Body mass index 0.726238 0.051070 5.824605e-07 0.626140 0.826336 RE IVW DF + HF 0.72
938 Tyrosine 95 Body mass index 0.295073 0.059098 5.946038e-07 0.179241 0.410904 FE IVW DF 0.79
UKB-a:500 Heel bone mineral density (BMD) T-score automated 95 Body mass index 0.144704 0.028997 6.028693e-07 0.087870 0.201539 FE IVW HF 0.72
891 Phospholipids in large VLDL 2 Body mass index 0.187048 0.037541 6.276724e-07 0.113468 0.260628 FE IVW DF 0.76
UKB-a:398 Qualifications: None of the above 2 Body mass index 0.021303 0.004284 6.606472e-07 0.006194 0.036413 FE IVW Tophits 0.78
771 HOMA-IR 95 Body mass index 0.190071 0.038288 6.896647e-07 0.115028 0.265114 Weighted median DF + HF 0.79
960 Triglycerides in chylomicrons and largest VLDL... 2 Body mass index 0.206441 0.041587 6.904912e-07 0.124929 0.287952 FE IVW DF + HF 0.79
UKB-a:149 Treatment/medication code: doxazosin 974 Body mass index 0.006075 0.001227 7.343694e-07 0.003671 0.008479 FE IVW DF 0.79
940 Valine 974 Body mass index 0.232191 0.046892 7.360607e-07 0.140282 0.324100 FE IVW DF 0.86
UKB-a:560 Diagnoses - main ICD10: L03 Cellulitis 835 Body mass index 0.005375 0.000976 7.446709e-07 0.003462 0.007288 Simple mean HF 0.82
UKB-a:20 Exposure to tobacco smoke outside home 2 Body mass index 0.034007 0.006872 7.486625e-07 0.018673 0.049341 FE IVW Tophits 0.77
1037 Difference in height between childhood and adu... 2 Body mass index -0.297414 0.053494 7.814717e-07 -0.402263 -0.192566 Simple mean DF 0.67
UKB-a:215 Illnesses of mother: High blood pressure 2 Body mass index 0.026500 0.005384 8.585962e-07 0.014033 0.038966 FE IVW DF 0.72
109 Waist-to-hip ratio 94 Body mass index 0.357965 0.072755 8.646801e-07 0.215369 0.500562 Penalised median DF + HF 0.70
UKB-a:16 Current tobacco smoking 974 Body mass index 0.059211 0.012044 8.824129e-07 0.035605 0.082817 Penalised median DF 0.83
71 Waist circumference 2 Body mass index 0.124490 0.022946 8.859776e-07 0.079515 0.169464 Simple mean DF + HF 0.85
UKB-a:262 Falls in the last year 974 Body mass index 0.048567 0.007817 8.885864e-07 0.033246 0.063887 Simple mean HF 0.75
UKB-a:190 Treatment/medication code: levothyroxine sodium 974 Body mass index 0.016802 0.002731 9.130873e-07 0.011449 0.022155 RE IVW HF 0.81
UKB-a:262 Falls in the last year 95 Body mass index 0.069381 0.014165 9.677194e-07 0.041618 0.097144 Weighted median HF 0.83
1055 Urate 785 Body mass index 0.270053 0.055198 9.959145e-07 0.161867 0.378239 Weighted median HF 0.77
7 Coronary heart disease 95 Body mass index 0.454937 0.093067 1.017140e-06 0.272530 0.637344 Penalised median DF 0.78
UKB-a:116 Treatment/medication code: lisinopril 835 Body mass index 0.010036 0.002053 1.020898e-06 0.004764 0.015308 FE IVW Tophits 0.74
771 HOMA-IR 94 Body mass index 0.217500 0.044713 1.148371e-06 0.129864 0.305136 Simple median HF 0.69
919 Phenylalanine 94 Body mass index 0.282053 0.058062 1.186861e-06 0.168252 0.395854 FE IVW DF 0.79
863 Glycoprotein acetyls 94 Body mass index 0.337150 0.069472 1.215699e-06 0.200986 0.473315 FE IVW HF 0.72
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic ... 835 Body mass index 0.011088 0.002060 1.234827e-06 0.007051 0.015126 RE IVW DF + HF 0.87
999 Body fat 95 Body mass index 0.517011 0.040146 1.249232e-06 0.438325 0.595696 Simple mean HF 0.70
770 HOMA-B 835 Body mass index 0.122731 0.025325 1.258152e-06 0.073095 0.172367 Simple median Tophits 0.85
8 Coronary heart disease 2 Body mass index 0.330890 0.068387 1.308513e-06 0.189942 0.471837 FE IVW DF 0.75
UKB-a:286 Arm fat percentage (left) 95 Body mass index 0.428836 0.022463 1.335928e-06 0.384808 0.472864 RE IVW DF + HF 0.67
960 Triglycerides in chylomicrons and largest VLDL... 974 Body mass index 0.253322 0.052416 1.345647e-06 0.150586 0.356058 FE IVW DF + HF 0.81
UKB-a:489 Medication for cholesterol blood pressure or d... 974 Body mass index -0.122780 0.020267 1.357784e-06 -0.162502 -0.083058 Penalised mode DF + HF 0.82
UKB-a:65 Non-cancer illness code self-reported: deep ve... 974 Body mass index 0.007816 0.001618 1.365822e-06 0.004644 0.010988 FE IVW DF + HF 0.80
UKB-a:310 Taking other prescription medications 785 Body mass index 0.047930 0.007322 1.388542e-06 0.033579 0.062281 RE IVW HF 0.90
940 Valine 95 Body mass index 0.228108 0.047269 1.394651e-06 0.135461 0.320755 FE IVW DF 0.78
UKB-a:160 Treatment/medication code: warfarin 2 Body mass index 0.006414 0.001221 1.447881e-06 0.004022 0.008806 Simple mean HF 0.89
864 Total cholesterol in HDL 2 Body mass index -0.223235 0.046449 1.539719e-06 -0.344770 -0.101700 FE IVW Tophits 0.67
UKB-a:437 Vascular/heart problems diagnosed by doctor: H... 95 Body mass index 0.069260 0.014420 1.563916e-06 0.040996 0.097524 Simple median HF 0.70
863 Glycoprotein acetyls 974 Body mass index 0.326902 0.056039 1.575100e-06 0.217067 0.436738 RE IVW HF 0.82
UKB-a:282 Arm fat percentage (right) 95 Body mass index 0.432474 0.023389 1.613621e-06 0.386631 0.478317 RE IVW DF + HF 0.67
950 Concentration of very large VLDL particles 974 Body mass index 0.262812 0.054866 1.667112e-06 0.142735 0.382890 FE IVW DF 0.75
UKB-a:528 Diagnoses - main ICD10: G56 Mononeuropathies o... 835 Body mass index 0.007528 0.001575 1.747793e-06 0.004442 0.010615 FE IVW HF 0.73
UKB-a:423 Eye problems/disorders: Diabetes related eye d... 835 Body mass index 0.022831 0.004777 1.756024e-06 0.013469 0.032193 Simple median HF 0.84
UKB-a:132 Treatment/medication code: aspirin 974 Body mass index 0.024939 0.004276 1.766364e-06 0.016558 0.033320 RE IVW HF 0.77
7 Coronary heart disease 835 Body mass index 0.359686 0.075569 1.938765e-06 0.211573 0.507798 Simple median Tophits 0.91
715 X-14056 835 Body mass index 0.078441 0.016484 1.949598e-06 0.046132 0.110751 FE IVW HF 0.73
UKB-a:50 Nervous feelings 2 Body mass index -0.043641 0.008485 1.956071e-06 -0.060271 -0.027011 RE IVW DF 0.74
1055 Urate 94 Body mass index 0.281321 0.059167 1.987414e-06 0.165356 0.397286 Penalised median DF + HF 0.75
941 Mean diameter for VLDL particles 95 Body mass index 0.164467 0.034619 2.026902e-06 0.096613 0.232321 FE IVW HF 0.71
360 Gamma-glutamyltyrosine 94 Body mass index 0.043600 0.009198 2.135339e-06 0.025572 0.061627 FE IVW HF 0.68
1032 Height 2 Body mass index 0.288911 0.061009 2.184687e-06 0.169333 0.408489 FE IVW DF 0.76
UKB-a:423 Eye problems/disorders: Diabetes related eye d... 785 Body mass index 0.020389 0.003337 2.191892e-06 0.013848 0.026930 RE IVW HF 0.82
UKB-a:34 Comparative body size at age 10 94 Body mass index 0.534533 0.030502 2.214794e-06 0.474750 0.594316 RE IVW HF 0.70
UKB-a:272 Impedance of arm (right) 2 Body mass index -0.287924 0.054238 2.220804e-06 -0.394228 -0.181620 Penalised mode DF + HF 0.78
UKB-a:299 Relative age of first facial hair 974 Body mass index -0.135669 0.024143 2.241933e-06 -0.182988 -0.088351 Simple mode Tophits 0.84
UKB-a:270 Impedance of leg (right) 974 Body mass index -0.401062 0.064213 2.258681e-06 -0.526918 -0.275206 Weighted mode DF + HF 0.63
798 Myocardial infarction 94 Body mass index 0.257741 0.054506 2.260203e-06 0.150909 0.364573 FE IVW HF 0.74
UKB-a:217 Illnesses of siblings: Heart disease 835 Body mass index 0.019673 0.004170 2.386687e-06 0.009761 0.029584 FE IVW DF 0.81
UKB-a:193 Treatment/medication code: bendroflumethiazide 785 Body mass index 0.016986 0.003603 2.416673e-06 0.009925 0.024047 FE IVW HF 0.80
876 Free cholesterol in large HDL 835 Body mass index -0.253450 0.053834 2.501580e-06 -0.358964 -0.147935 FE IVW DF 0.66
UKB-a:184 Treatment/medication code: rosiglitazone 2 Body mass index 0.002011 0.000428 2.577166e-06 0.001074 0.002947 FE IVW DF 0.77
UKB-a:218 Illnesses of siblings: None of the above (grou... 2 Body mass index -0.068043 0.014490 2.653487e-06 -0.096443 -0.039643 FE Egger HF 0.74
524 X-11491 94 Body mass index 0.136380 0.029053 2.677623e-06 0.079435 0.193325 FE IVW DF + HF 0.66
UKB-a:149 Treatment/medication code: doxazosin 95 Body mass index 0.006859 0.001463 2.754594e-06 0.003991 0.009726 FE IVW HF 0.83
843 Apolipoprotein B 974 Body mass index 0.249886 0.053319 2.777388e-06 0.145381 0.354391 FE IVW DF + HF 0.75
UKB-a:225 Smoking status: Current 2 Body mass index 0.018187 0.003881 2.790677e-06 0.010579 0.025794 FE IVW HF 0.71
UKB-a:117 Treatment/medication code: ramipril 95 Body mass index 0.021054 0.004495 2.816226e-06 0.012244 0.029864 Simple median HF 0.77
950 Concentration of very large VLDL particles 95 Body mass index 0.265777 0.056831 2.916327e-06 0.154388 0.377165 FE IVW DF 0.74
952 Triglycerides in very large VLDL 2 Body mass index 0.219501 0.046997 3.004029e-06 0.124861 0.314140 FE IVW Tophits 0.65
961 Cigarettes smoked per day 2 Body mass index 1.840032 0.394699 3.133649e-06 0.992392 2.687673 FE IVW DF 0.74
UKB-a:433 Mouth/teeth dental problems: Dentures 835 Body mass index 0.038477 0.008265 3.231084e-06 0.022278 0.054675 Penalised median DF 0.75
884 Concentration of large LDL particles 2 Body mass index 0.205196 0.044148 3.352726e-06 0.118666 0.291725 FE IVW HF 0.69
897 Leucine 785 Body mass index 0.173362 0.037346 3.450066e-06 0.100163 0.246560 FE IVW DF + HF 0.71
UKB-a:132 Treatment/medication code: aspirin 835 Body mass index 0.031564 0.006801 3.462775e-06 0.018235 0.044894 Simple median Tophits 0.85
UKB-a:16 Current tobacco smoking 835 Body mass index 0.056810 0.012247 3.508471e-06 0.032806 0.080814 Penalised median DF 0.77
UKB-a:172 Treatment/medication code: co-codamol 835 Body mass index 0.008729 0.001883 3.569964e-06 0.004210 0.013248 FE IVW Tophits 0.76
UKB-a:267 Whole body water mass 95 Body mass index 0.435105 0.026943 3.584638e-06 0.382297 0.487913 RE IVW HF 0.66
UKB-a:66 Non-cancer illness code self-reported: asthma 2 Body mass index 0.016753 0.003616 3.613049e-06 0.007626 0.025880 FE IVW Tophits 0.78
UKB-a:16 Current tobacco smoking 2 Body mass index 0.053218 0.011499 3.688337e-06 0.030681 0.075755 Penalised median DF 0.75
UKB-a:494 Mineral and other dietary supplements: Glucosa... 785 Body mass index 0.026784 0.004539 3.710936e-06 0.017887 0.035682 RE IVW HF 0.82
770 HOMA-B 95 Body mass index 0.105224 0.022752 3.748736e-06 0.054720 0.155729 FE IVW DF 0.77
UKB-a:334 Potassium in urine 785 Body mass index 0.097322 0.021048 3.767123e-06 0.056069 0.138575 Penalised median DF 0.81
UKB-a:475 Pain type(s) experienced in last month: Hip pain 94 Body mass index 0.033017 0.007142 3.777035e-06 0.019020 0.047015 Penalised median DF 0.76
UKB-a:483 Types of physical activity in last 4 weeks: No... 2 Body mass index 0.012230 0.002650 3.928790e-06 0.004965 0.019495 FE IVW DF 0.78
UKB-a:528 Diagnoses - main ICD10: G56 Mononeuropathies o... 2 Body mass index 0.008180 0.001650 4.093052e-06 0.004945 0.011415 Simple mean DF 0.71
909 Total cholesterol in medium VLDL 2 Body mass index 0.232015 0.046607 4.239052e-06 0.140666 0.323364 Simple mean HF 0.73
UKB-a:239 Loneliness isolation 2 Body mass index 0.019906 0.004331 4.305640e-06 0.006492 0.033319 FE IVW Tophits 0.73
UKB-a:452 Medication for pain relief constipation heartb... 974 Body mass index 0.025649 0.004643 4.314422e-06 0.016549 0.034748 RE IVW HF 0.76
UKB-a:117 Treatment/medication code: ramipril 785 Body mass index 0.021647 0.004711 4.339012e-06 0.012412 0.030881 Penalised median HF 0.81
863 Glycoprotein acetyls 835 Body mass index 0.227832 0.049594 4.348832e-06 0.130628 0.325035 FE IVW DF 0.72
UKB-a:69 Non-cancer illness code self-reported: sleep a... 2 Body mass index 0.002906 0.000634 4.519245e-06 0.001650 0.004163 FE IVW Tophits 0.73
UKB-a:184 Treatment/medication code: rosiglitazone 94 Body mass index 0.003883 0.000848 4.652897e-06 0.002221 0.005544 Penalised median HF 0.76
UKB-a:153 Treatment/medication code: insulin product 785 Body mass index 0.007457 0.001298 4.790727e-06 0.004912 0.010001 RE IVW DF + HF 0.80
758 HbA1C 2 Body mass index 0.069716 0.015252 4.854137e-06 0.039822 0.099609 FE IVW DF 0.77
1144 Docosapentaenoic acid (22:5n3) 2 Body mass index -0.057471 0.012578 4.896663e-06 -0.082124 -0.032818 FE IVW Tophits 0.66
UKB-a:225 Smoking status: Current 974 Body mass index 0.030327 0.006637 4.897689e-06 0.017318 0.043336 Simple median Tophits 0.85
UKB-a:218 Illnesses of siblings: None of the above (grou... 94 Body mass index -0.059288 0.012992 5.032516e-06 -0.084751 -0.033824 Penalised median HF 0.80
UKB-a:380 Shortness of breath walking on level ground 974 Body mass index 0.039275 0.007145 5.163031e-06 0.025271 0.053279 RE IVW DF + HF 0.77
UKB-a:168 Treatment/medication code: losartan 2 Body mass index 0.004168 0.000914 5.166515e-06 0.002375 0.005960 FE IVW DF + HF 0.84
UKB-a:164 Treatment/medication code: furosemide 835 Body mass index 0.007573 0.001662 5.212877e-06 0.004315 0.010831 Weighted median HF 0.85
873 Isoleucine 835 Body mass index 0.204230 0.044857 5.292040e-06 0.116309 0.292150 FE IVW DF 0.83
53 Hip circumference 94 Body mass index 0.666972 0.054112 5.311184e-06 0.560912 0.773032 Simple mean DF + HF 0.67
UKB-a:431 Mouth/teeth dental problems: Loose teeth 2 Body mass index 0.010003 0.002202 5.554843e-06 0.004878 0.015129 FE IVW Tophits 0.79
UKB-a:23 Number of operations self-reported 2 Body mass index 0.069605 0.015325 5.574992e-06 0.039568 0.099641 Simple median Tophits 0.83
UKB-a:273 Impedance of arm (left) 2 Body mass index -0.288151 0.056871 5.667996e-06 -0.399617 -0.176686 Penalised mode DF + HF 0.78
883 Total lipids in large LDL 2 Body mass index 0.202204 0.044711 6.111375e-06 0.114571 0.289837 FE IVW HF 0.68
UKB-a:446 Blood clot DVT bronchitis emphysema asthma rhi... 2 Body mass index 0.016323 0.003609 6.116306e-06 0.007168 0.025477 FE IVW Tophits 0.73
UKB-a:164 Treatment/medication code: furosemide 785 Body mass index 0.007222 0.001272 6.545145e-06 0.004729 0.009716 RE IVW HF 0.84
911 Free cholesterol in medium VLDL 2 Body mass index 0.209729 0.046603 6.784732e-06 0.109782 0.309675 FE IVW Tophits 0.74
UKB-a:208 Illnesses of father: Diabetes 835 Body mass index 0.025911 0.005758 6.798789e-06 0.014625 0.037196 Weighted median HF 0.91
8 Coronary heart disease 974 Body mass index 0.328476 0.073081 6.966327e-06 0.161582 0.495370 FE IVW DF 0.85
505 X-03056--N-[3-(2-Oxopyrrolidin-1-yl)propyl]ace... 94 Body mass index 0.046882 0.010434 7.018774e-06 0.026431 0.067333 FE IVW HF 0.65
897 Leucine 835 Body mass index 0.191116 0.042586 7.195339e-06 0.107649 0.274584 FE IVW DF 0.82
1024 Multiple sclerosis 95 Body mass index 0.428577 0.095548 7.275980e-06 0.241302 0.615851 FE IVW DF 1.00
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic ... 974 Body mass index 0.008423 0.001878 7.299192e-06 0.004742 0.012104 FE IVW DF + HF 0.85
960 Triglycerides in chylomicrons and largest VLDL... 95 Body mass index 0.238896 0.053302 7.397765e-06 0.134424 0.343368 FE IVW Tophits 0.66
768 Fasting insulin 94 Body mass index 0.177366 0.039590 7.461088e-06 0.099771 0.254961 Weighted median DF + HF 0.74
UKB-a:108 Non-cancer illness code self-reported: high ch... 835 Body mass index 0.030967 0.006913 7.491155e-06 0.017417 0.044517 Penalised median DF 0.85
541 X-11787 94 Body mass index 0.035688 0.007974 7.623318e-06 0.020059 0.051316 FE IVW DF 0.75
UKB-a:360 Systolic blood pressure automated reading 2 Body mass index 0.096812 0.021660 7.837462e-06 0.054358 0.139265 Weighted median Tophits 0.72
UKB-a:433 Mouth/teeth dental problems: Dentures 2 Body mass index 0.037082 0.008301 7.919486e-06 0.020813 0.053351 Simple median DF + HF 0.74
UKB-a:271 Impedance of leg (left) 785 Body mass index -0.646189 0.116458 7.948204e-06 -0.874443 -0.417935 Simple mode Tophits 0.65
974 Body mass index 94 Body mass index 0.785595 0.055724 7.951599e-06 0.676376 0.894815 Simple mean DF + HF 0.78
UKB-a:132 Treatment/medication code: aspirin 95 Body mass index 0.037289 0.008359 8.162286e-06 0.020905 0.053672 Penalised median DF 0.77
299 HDL cholesterol 835 Body mass index -0.196861 0.040339 8.182236e-06 -0.275926 -0.117796 Simple mean DF 0.79
UKB-a:252 Long-standing illness disability or infirmity 94 Body mass index 0.052922 0.011874 8.307769e-06 0.029650 0.076193 Penalised median HF 0.82
UKB-a:294 Wheeze or whistling in the chest in last year 974 Body mass index 0.038737 0.008695 8.382842e-06 0.021695 0.055779 Simple median HF 0.89
UKB-a:108 Non-cancer illness code self-reported: high ch... 94 Body mass index 0.032625 0.007328 8.496320e-06 0.018263 0.046987 Weighted median Tophits 0.71
UKB-a:131 Treatment/medication code: atenolol 835 Body mass index 0.010746 0.002417 8.753071e-06 0.004166 0.017326 FE IVW DF 0.82
UKB-a:216 Illnesses of mother: Diabetes 94 Body mass index 0.032522 0.007323 8.939319e-06 0.018170 0.046874 Simple median Tophits 0.67
UKB-a:369 Health satisfaction 95 Body mass index 0.160039 0.017888 8.961234e-06 0.124979 0.195099 RE IVW HF 0.77
1107 Urinary albumin-to-creatinine ratio 2 Body mass index 0.123606 0.025886 9.182300e-06 0.072870 0.174343 Simple mean DF + HF 0.67
UKB-a:237 Pack years of smoking PREVIEW ONLY 2 Body mass index 0.160522 0.036213 9.307040e-06 0.089545 0.231498 Simple median Tophits 0.74
UKB-a:294 Wheeze or whistling in the chest in last year 95 Body mass index 0.045233 0.010221 9.624148e-06 0.025200 0.065267 Penalised median HF 0.87
952 Triglycerides in very large VLDL 974 Body mass index 0.227938 0.051510 9.639993e-06 0.122292 0.333585 FE IVW DF 0.79

Query diagram

Cypher query

MATCH (t1:Gwas)-[r:MR]->(t2:Gwas) WHERE t1.trait = "Body mass index" AND r.p < 1e-05 RETURN t1.id AS exposure_id, t1.trait AS exposure_name, t2.id AS outcome_id, t2.trait AS outcome_name, r.estimate AS estimate, r.se AS se, r.p AS p, r.ci_upp as ci_upp, r.ci_low AS ci_low, r.selection AS selection, r.method AS method, r.moescore AS moescore ORDER BY r.p ;

API call

curl -X 'GET' -H 'Accept: */*' -H 'Accept-Encoding: gzip, deflate' -H 'Connection: keep-alive' -H 'User-Agent: python-requests/2.22.0' 'http://api.epigraphdb.org/mr?exposure=Body+mass+index&pval_threshold=1e-05'

Response data

{
    "query": "MATCH (t1:Gwas)-[r:MR]->(t2:Gwas) WHERE t1.trait = \"Body mass index\" AND r.p < 1e-05 RETURN t1.id AS exposure_id, t1.trait AS exposure_name, t2.id AS outcome_id, t2.trait AS outcome_name, r.estimate AS estimate, r.se AS se, r.p AS p, r.ci_upp as ci_upp, r.ci_low AS ci_low, r.selection AS selection, r.method AS method, r.moescore AS moescore ORDER BY r.p ;",
    "results": [
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:282",
            "outcome_name": "Arm fat percentage (right)",
            "estimate": 0.525751286439372,
            "se": 0.0123237191431141,
            "p": 0.0,
            "ci_upp": 0.549905775959876,
            "ci_low": 0.501596796918869,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.94
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "48",
            "outcome_name": "Hip circumference",
            "estimate": 0.828391732615896,
            "se": 0.0148689482599007,
            "p": 0.0,
            "ci_upp": 0.857534871205302,
            "ci_low": 0.799248594026491,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.91
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "65",
            "outcome_name": "Waist circumference",
            "estimate": 0.778973085173108,
            "se": 0.0191057492394542,
            "p": 0.0,
            "ci_upp": 0.816420353682439,
            "ci_low": 0.741525816663778,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.88
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "85",
            "outcome_name": "Extreme body mass index",
            "estimate": 3.81829869313643,
            "se": 0.0911058575787327,
            "p": 0.0,
            "ci_upp": 3.99686617399075,
            "ci_low": 3.63973121228212,
            "selection": "HF",
            "method": "FE IVW",
            "moescore": 0.79
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "93",
            "outcome_name": "Overweight",
            "estimate": 1.67110267249323,
            "se": 0.03407574916161,
            "p": 0.0,
            "ci_upp": 1.73789114084998,
            "ci_low": 1.60431420413647,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.84
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "60",
            "outcome_name": "Waist circumference",
            "estimate": 0.819575102671793,
            "se": 0.0194836876554876,
            "p": 0.0,
            "ci_upp": 0.857763130476548,
            "ci_low": 0.781387074867037,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.9
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "61",
            "outcome_name": "Waist circumference",
            "estimate": 0.823566323565697,
            "se": 0.0194413176088615,
            "p": 0.0,
            "ci_upp": 0.861671306079065,
            "ci_low": 0.785461341052328,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.94
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "64",
            "outcome_name": "Waist circumference",
            "estimate": 0.782720613125147,
            "se": 0.0192552614787275,
            "p": 0.0,
            "ci_upp": 0.820460925623452,
            "ci_low": 0.744980300626841,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.89
        },
        {
            "exposure_id": "94",
            "exposure_name": "Body mass index",
            "outcome_id": "1017",
            "outcome_name": "Immunoglobulin G index levels",
            "estimate": -101.187347874484,
            "se": 1.37049253294439,
            "p": 0.0,
            "ci_upp": -98.5011825099135,
            "ci_low": -103.873513239055,
            "selection": "DF",
            "method": "FE IVW",
            "moescore": 1.0
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "50",
            "outcome_name": "Hip circumference",
            "estimate": 0.8362760051717,
            "se": 0.0229811227320127,
            "p": 6.19635605778455e-290,
            "ci_upp": 0.881319005726445,
            "ci_low": 0.791233004616955,
            "selection": "HF",
            "method": "FE IVW",
            "moescore": 0.89
        },
        {
            "exposure_id": "95",
            "exposure_name": "Body mass index",
            "outcome_id": "974",
            "outcome_name": "Body mass index",
            "estimate": 0.980908388753165,
            "se": 0.0279248825441792,
            "p": 2.6395826305138e-270,
            "ci_upp": 1.03564115853976,
            "ci_low": 0.926175618966574,
            "selection": "HF",
            "method": "FE IVW",
            "moescore": 0.74
        },
        {
            "exposure_id": "785",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:248",
            "outcome_name": "Body mass index (BMI)",
            "estimate": 0.810138452701632,
            "se": 0.023880046172794,
            "p": 2.81963376771788e-252,
            "ci_upp": 0.891556186153144,
            "ci_low": 0.728720719250119,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.87
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "52",
            "outcome_name": "Hip circumference",
            "estimate": 0.797228817422827,
            "se": 0.0235012716981874,
            "p": 3.07312251112972e-252,
            "ci_upp": 0.843291309951274,
            "ci_low": 0.751166324894379,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.85
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "53",
            "outcome_name": "Hip circumference",
            "estimate": 0.810897649950893,
            "se": 0.0241435907199952,
            "p": 2.64508268081817e-247,
            "ci_upp": 0.858219087762084,
            "ci_low": 0.763576212139703,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.85
        },
        {
            "exposure_id": "785",
            "exposure_name": "Body mass index",
            "outcome_id": "52",
            "outcome_name": "Hip circumference",
            "estimate": 0.777492841297306,
            "se": 0.023170098103267,
            "p": 7.39173767357429e-247,
            "ci_upp": 0.82290623357971,
            "ci_low": 0.732079449014903,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.92
        },
        {
            "exposure_id": "974",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:286",
            "outcome_name": "Arm fat percentage (left)",
            "estimate": 0.507869877896767,
            "se": 0.015141218332295,
            "p": 1.16956106805739e-246,
            "ci_upp": 0.537546665828065,
            "ci_low": 0.478193089965469,
            "selection": "HF",
            "method": "FE IVW",
            "moescore": 0.88
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:277",
            "outcome_name": "Leg predicted mass (right)",
            "estimate": 0.426754844563101,
            "se": 0.013008739492778,
            "p": 4.95714747088488e-236,
            "ci_upp": 0.452251973968946,
            "ci_low": 0.401257715157256,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.91
        },
        {
            "exposure_id": "974",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:282",
            "outcome_name": "Arm fat percentage (right)",
            "estimate": 0.497229219522513,
            "se": 0.0154736337231508,
            "p": 1.47945742520751e-226,
            "ci_upp": 0.527557541619888,
            "ci_low": 0.466900897425137,
            "selection": "HF",
            "method": "FE IVW",
            "moescore": 0.88
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:290",
            "outcome_name": "Trunk fat percentage",
            "estimate": 0.526828109140363,
            "se": 0.0171161324121963,
            "p": 4.9105946142507e-208,
            "ci_upp": 0.56563601679405,
            "ci_low": 0.488020201486677,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.92
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "94",
            "outcome_name": "Body mass index",
            "estimate": 0.857565245734554,
            "se": 0.0279736750336661,
            "p": 2.18803180496804e-206,
            "ci_upp": 0.91239364880054,
            "ci_low": 0.802736842668569,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.92
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:283",
            "outcome_name": "Arm fat mass (right)",
            "estimate": 0.807171068796069,
            "se": 0.0265652195339796,
            "p": 8.80105035063067e-203,
            "ci_upp": 0.859237942324069,
            "ci_low": 0.755104195268069,
            "selection": "Tophits",
            "method": "Simple median",
            "moescore": 0.94
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:267",
            "outcome_name": "Whole body water mass",
            "estimate": 0.377597184157694,
            "se": 0.0124401870490648,
            "p": 2.29253722655614e-202,
            "ci_upp": 0.403826841990966,
            "ci_low": 0.351367526324421,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.93
        },
        {
            "exposure_id": "785",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:388",
            "outcome_name": "Hip circumference",
            "estimate": 0.667273922852807,
            "se": 0.0220275016302682,
            "p": 1.42763809657936e-201,
            "ci_upp": 0.741633795820253,
            "ci_low": 0.592914049885361,
            "selection": "Tophits",
            "method": "FE IVW",
            "moescore": 0.91
        },
        {
            "exposure_id": "835",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:266",
            "outcome_name": "Whole body fat-free mass",
            "estimate": 0.373149084163058,
            "se": 0.0124588197789275,
            "p": 4.32190141288174e-197,
            "ci_upp": 0.399254264859231,
            "ci_low": 0.347043903466886,
            "selection": "DF + HF",
            "method": "FE IVW",
            "moescore": 0.93
        },
        {
            "exposure_id": "2",
            "exposure_name": "Body mass index",
            "outcome_id": "UKB-a:248",
            "outcome_name": "Body mass index (BMI)",
            "estimate": 0.841602649006622,
            "se": 0.0282287238502265,
            "p": 2.59585628534663e-195,
            "ci_upp": 0.896929931082593,
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