Confounder MR causal estimate

MR evidence on confounding traits between exposure and outcome

Exposure
Outcome

 

Confounder type:                         
P-value threshold: 1e-5
   

 

 

Summary

This module provides 4 different queries for traits causally related to an exposure-outcome pair using data from MR-EvE (Hemani et al, bioRxiv 10.1101/173682).

confounder
intermediate
reverse_intermediate
collider

 Data sources

  • MR-EvE (Hemani et al, Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome, bioRxiv 10.1101/173682)

 How to use

Enter an exposure and outcome pair of traits, then select whether you want to find potential confounders, colliders or intermediates (either forward or reverse). Finally, choose a p-value threshold for the strength of MR evidence to include, then click the Search button.

View the top results in the Network plot tab, access and search the full results in the Table tab, or use the Query tab to find out how to download data using the API.

Examples

 Displays 50 / 105 paths

 

cf.id cf.trait exposure.id exposure.trait outcome.id outcome.trait r1.estimate r1.method r1.moescore r1.p r1.se r1.selection r2.estimate r2.method r2.moescore r2.p r2.se r2.selection r3.estimate r3.method r3.moescore r3.p r3.se r3.selection
60 Waist circumference 835 Body mass index 7 Coronary heart disease 0.860649 FE IVW 0.88 0.000000e+00 0.020650 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.516146 Simple mean 0.93 1.890171e-12 0.051576 HF
UKB-a:124 Treatment/medication code: becotide 50 inhaler 974 Body mass index 8 Coronary heart disease -5.139005 FE IVW 1.00 0.000000e+00 0.108362 DF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF -16.164327 FE IVW 1.00 0.000000e+00 0.031138 DF
51 Hip circumference 95 Body mass index 7 Coronary heart disease 0.929249 FE IVW 0.82 1.366521e-133 0.037779 DF + HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
63 Waist circumference 95 Body mass index 7 Coronary heart disease 0.929249 FE IVW 0.82 1.366521e-133 0.037779 DF + HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
638 Asparagine 835 Body mass index 7 Coronary heart disease -0.215321 FE IVW 1.00 1.019592e-132 0.008783 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.418985 FE IVW 1.00 5.542329e-06 0.092224 DF
62 Waist circumference 95 Body mass index 7 Coronary heart disease 1.019881 FE IVW 0.79 6.715630e-103 0.047350 Tophits 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.482268 FE IVW 0.81 5.431067e-11 0.073532 HF
307 Cholesterol 974 Body mass index 7 Coronary heart disease -0.611157 FE IVW 1.00 8.967038e-95 0.029590 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 5.722505 FE IVW 1.00 9.314398e-11 0.883419 DF
307 Cholesterol 974 Body mass index 8 Coronary heart disease -0.611157 FE IVW 1.00 8.967038e-95 0.029590 DF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 7.057320 FE IVW 1.00 1.314346e-06 1.458856 DF
51 Hip circumference 974 Body mass index 7 Coronary heart disease 1.037371 FE IVW 0.73 2.654135e-81 0.054320 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
63 Waist circumference 974 Body mass index 7 Coronary heart disease 1.037371 FE IVW 0.73 2.654135e-81 0.054320 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
60 Waist circumference 974 Body mass index 7 Coronary heart disease 0.980909 Simple median 0.88 1.348071e-72 0.054433 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.516146 Simple mean 0.93 1.890171e-12 0.051576 HF
90 Obesity class 1 835 Body mass index 7 Coronary heart disease 0.348926 Simple median 0.83 1.373343e-68 0.019936 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.161878 Simple mean 0.88 4.516976e-07 0.019211 HF
65 Waist circumference 835 Body mass index 7 Coronary heart disease 1.048331 Weighted median 0.78 1.985022e-63 0.062355 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.519883 Penalised median 0.81 2.835560e-07 0.101262 HF
90 Obesity class 1 2 Body mass index 7 Coronary heart disease 0.340000 Simple median 0.80 4.177422e-62 0.020444 HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.161878 Simple mean 0.88 4.516976e-07 0.019211 HF
60 Waist circumference 2 Body mass index 7 Coronary heart disease 0.921053 Simple median 0.88 8.045873e-56 0.058517 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.516146 Simple mean 0.93 1.890171e-12 0.051576 HF
65 Waist circumference 974 Body mass index 7 Coronary heart disease 0.738726 FE IVW 0.80 7.928597e-55 0.047371 DF + HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.519883 Penalised median 0.81 2.835560e-07 0.101262 HF
91 Obesity class 2 2 Body mass index 7 Coronary heart disease 0.258652 Penalised median 0.81 2.875517e-53 0.016835 HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.104290 FE IVW 0.73 3.742677e-07 0.020523 HF
90 Obesity class 1 974 Body mass index 7 Coronary heart disease 0.360173 Simple median 0.80 1.366487e-52 0.023599 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.161878 Simple mean 0.88 4.516976e-07 0.019211 HF
91 Obesity class 2 835 Body mass index 7 Coronary heart disease 0.268615 Penalised median 0.77 1.360872e-50 0.017957 HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.104290 FE IVW 0.73 3.742677e-07 0.020523 HF
496 X-11317 2 Body mass index 7 Coronary heart disease -0.228361 FE IVW 1.00 3.576629e-47 0.015830 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF -1.122637 FE IVW 1.00 5.846781e-209 0.036392 DF
61 Waist circumference 95 Body mass index 7 Coronary heart disease 1.030035 Weighted median 0.92 5.055364e-46 0.072326 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.572287 Simple mean 0.96 1.593663e-12 0.053022 HF
UKB-a:34 Comparative body size at age 10 2 Body mass index 7 Coronary heart disease 0.854604 Penalised median 0.62 3.575718e-43 0.062038 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.387252 RE IVW 0.81 1.422145e-11 0.052405 HF
91 Obesity class 2 974 Body mass index 7 Coronary heart disease 0.269874 Penalised median 0.84 2.063579e-42 0.019773 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.104290 FE IVW 0.73 3.742677e-07 0.020523 HF
61 Waist circumference 835 Body mass index 7 Coronary heart disease 0.863855 Weighted median 0.91 1.206971e-41 0.063899 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.572287 Simple mean 0.96 1.593663e-12 0.053022 HF
162 CD32 on 11c+123+DC 95 Body mass index 7 Coronary heart disease -0.031138 FE IVW 1.00 8.481781e-41 0.002328 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.045278 FE IVW 1.00 7.879091e-28 0.004141 DF
UKB-a:452 Medication for pain relief constipation heartburn: Aspirin 974 Body mass index 7 Coronary heart disease -1.594824 FE IVW 0.68 4.808627e-36 0.127231 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 7.716303 Weighted median 0.67 4.051923e-08 1.405885 Tophits
UKB-a:452 Medication for pain relief constipation heartburn: Aspirin 974 Body mass index 8 Coronary heart disease -1.594824 FE IVW 0.68 4.808627e-36 0.127231 HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF -1.985062 FE IVW 1.00 6.999204e-82 0.103567 DF
62 Waist circumference 2 Body mass index 7 Coronary heart disease 0.930591 Penalised median 0.78 3.845519e-34 0.076387 HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.482268 FE IVW 0.81 5.431067e-11 0.073532 HF
UKB-a:287 Arm fat mass (left) 835 Body mass index 7 Coronary heart disease 0.675230 Simple mode 0.66 3.953200e-34 0.046123 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.367980 Simple median 0.83 9.784494e-12 0.054038 HF
62 Waist circumference 835 Body mass index 7 Coronary heart disease 0.891218 Simple median 0.78 4.584212e-33 0.074399 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.482268 FE IVW 0.81 5.431067e-11 0.073532 HF
UKB-a:283 Arm fat mass (right) 835 Body mass index 7 Coronary heart disease 0.691107 Simple mode 0.68 4.592477e-32 0.049344 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.405549 Simple median 0.84 2.898637e-14 0.053342 HF
UKB-a:283 Arm fat mass (right) 2 Body mass index 7 Coronary heart disease 0.686146 Simple mode 0.67 6.918027e-30 0.051584 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.405549 Simple median 0.84 2.898637e-14 0.053342 HF
UKB-a:283 Arm fat mass (right) 95 Body mass index 7 Coronary heart disease 0.580696 Penalised median 0.58 2.240417e-29 0.051604 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.405549 Simple median 0.84 2.898637e-14 0.053342 HF
UKB-a:163 Treatment/medication code: flecainide 974 Body mass index 8 Coronary heart disease -3.526281 FE IVW 1.00 5.586487e-29 0.315634 DF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF -13.608858 FE IVW 1.00 3.423981e-279 0.381158 DF
638 Asparagine 2 Body mass index 7 Coronary heart disease -0.220630 FE IVW 1.00 6.324446e-29 0.019768 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.418985 FE IVW 1.00 5.542329e-06 0.092224 DF
102 Waist circumference 974 Body mass index 7 Coronary heart disease 0.859485 FE IVW 1.00 8.553527e-27 0.080205 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.360006 FE IVW 1.00 0.000000e+00 0.009528 DF
UKB-a:287 Arm fat mass (left) 2 Body mass index 7 Coronary heart disease 0.663668 Simple mode 0.65 3.814408e-26 0.054742 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.367980 Simple median 0.83 9.784494e-12 0.054038 HF
51 Hip circumference 835 Body mass index 7 Coronary heart disease 0.850901 Weighted median 0.80 1.351985e-25 0.081367 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
60 Waist circumference 95 Body mass index 7 Coronary heart disease 1.069912 Simple mean 0.94 6.723515e-25 0.042446 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.516146 Simple mean 0.93 1.890171e-12 0.051576 HF
UKB-a:275 Leg fat mass (right) 835 Body mass index 7 Coronary heart disease 0.845767 Simple mode 0.68 6.821135e-25 0.072395 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.360455 Simple median 0.82 5.916537e-08 0.066489 HF
92 Obesity class 3 974 Body mass index 8 Coronary heart disease 0.196756 FE IVW 1.00 3.246295e-24 0.019381 DF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.076601 FE IVW 1.00 2.961340e-08 0.013818 DF
UKB-a:279 Leg fat mass (left) 835 Body mass index 7 Coronary heart disease 0.865182 Simple mode 0.69 5.311255e-24 0.075977 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.366622 Simple median 0.80 5.570697e-08 0.067492 HF
63 Waist circumference 835 Body mass index 7 Coronary heart disease 0.850901 Weighted median 0.80 9.106667e-24 0.084660 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
UKB-a:282 Arm fat percentage (right) 974 Body mass index 7 Coronary heart disease 0.962632 Penalised mode 0.67 9.302738e-24 0.082854 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.472462 Weighted median 0.84 5.307805e-10 0.076084 HF
UKB-a:282 Arm fat percentage (right) 2 Body mass index 7 Coronary heart disease 0.837399 Simple mode 0.68 2.986506e-23 0.073223 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.472462 Weighted median 0.84 5.307805e-10 0.076084 HF
UKB-a:279 Leg fat mass (left) 2 Body mass index 7 Coronary heart disease 0.859073 Simple mode 0.73 4.302183e-23 0.077445 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.366622 Simple median 0.80 5.570697e-08 0.067492 HF
UKB-a:282 Arm fat percentage (right) 835 Body mass index 7 Coronary heart disease 0.852720 Simple mode 0.73 9.763353e-23 0.075726 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.472462 Weighted median 0.84 5.307805e-10 0.076084 HF
65 Waist circumference 2 Body mass index 7 Coronary heart disease 0.926989 Weighted median 0.77 1.198674e-22 0.094652 HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.519883 Penalised median 0.81 2.835560e-07 0.101262 HF
UKB-a:248 Body mass index (BMI) 2 Body mass index 7 Coronary heart disease 0.709770 Simple mode 0.65 2.244759e-22 0.066082 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.353634 Simple median 0.80 9.473961e-14 0.047480 HF
UKB-a:275 Leg fat mass (right) 2 Body mass index 7 Coronary heart disease 0.835909 Simple mode 0.72 9.583195e-22 0.078485 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.360455 Simple median 0.82 5.916537e-08 0.066489 HF
UKB-a:382 Waist circumference 835 Body mass index 7 Coronary heart disease 0.827170 Simple mode 0.65 2.366097e-20 0.078902 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.368378 Simple median 0.86 3.054552e-08 0.066515 Tophits
62 Waist circumference 974 Body mass index 7 Coronary heart disease 0.910877 Simple median 0.73 3.615833e-20 0.099020 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.482268 FE IVW 0.81 5.431067e-11 0.073532 HF
UKB-a:382 Waist circumference 2 Body mass index 7 Coronary heart disease 0.768679 Weighted mode 0.70 6.958562e-20 0.074442 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.368378 Simple median 0.86 3.054552e-08 0.066515 Tophits
UKB-a:283 Arm fat mass (right) 974 Body mass index 7 Coronary heart disease 0.429888 Penalised median 0.61 6.585004e-19 0.048402 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.405549 Simple median 0.84 2.898637e-14 0.053342 HF
UKB-a:279 Leg fat mass (left) 95 Body mass index 7 Coronary heart disease 0.578516 Penalised median 0.63 1.016373e-17 0.067488 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.366622 Simple median 0.80 5.570697e-08 0.067492 HF
UKB-a:34 Comparative body size at age 10 95 Body mass index 7 Coronary heart disease 0.913397 Penalised median 0.66 8.850471e-17 0.109793 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.387252 RE IVW 0.81 1.422145e-11 0.052405 HF
UKB-a:265 Whole body fat mass 2 Body mass index 7 Coronary heart disease 0.598325 Simple mode 0.66 3.561506e-16 0.067933 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.312677 Simple median 0.88 2.582318e-08 0.056160 HF
81 Waist-to-hip ratio 835 Body mass index 7 Coronary heart disease -0.233006 Weighted median 0.71 3.807831e-16 0.028609 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.299076 FE IVW 0.88 4.684574e-10 0.048011 Tophits
UKB-a:265 Whole body fat mass 835 Body mass index 7 Coronary heart disease 0.605029 Simple mode 0.67 3.889445e-16 0.068774 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.312677 Simple median 0.88 2.582318e-08 0.056160 HF
UKB-a:291 Trunk fat mass 2 Body mass index 7 Coronary heart disease 0.586717 Simple mode 0.70 6.474842e-16 0.067353 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.255400 FE IVW 0.82 6.364277e-16 0.031601 DF
UKB-a:382 Waist circumference 95 Body mass index 7 Coronary heart disease 0.525933 Penalised median 0.62 7.791869e-16 0.065273 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.368378 Simple median 0.86 3.054552e-08 0.066515 Tophits
61 Waist circumference 974 Body mass index 7 Coronary heart disease 0.833109 RE IVW 0.88 5.936781e-15 0.030054 DF + HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.572287 Simple mean 0.96 1.593663e-12 0.053022 HF
90 Obesity class 1 95 Body mass index 7 Coronary heart disease 0.377866 RE IVW 0.88 2.902962e-14 0.012269 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.161878 Simple mean 0.88 4.516976e-07 0.019211 HF
UKB-a:291 Trunk fat mass 835 Body mass index 7 Coronary heart disease 0.593631 Simple mode 0.69 3.072501e-14 0.073137 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.255400 FE IVW 0.82 6.364277e-16 0.031601 DF
UKB-a:124 Treatment/medication code: becotide 50 inhaler 2 Body mass index 8 Coronary heart disease -4.991635 FE IVW 1.00 6.997612e-14 0.666626 DF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF -16.164327 FE IVW 1.00 0.000000e+00 0.031138 DF
61 Waist circumference 2 Body mass index 7 Coronary heart disease 0.852659 Simple mean 0.87 8.955366e-14 0.026527 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.572287 Simple mean 0.96 1.593663e-12 0.053022 HF
900 Free cholesterol in medium HDL 95 Body mass index 7 Coronary heart disease -0.083577 FE IVW 1.00 3.250220e-13 0.011475 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF -0.186480 FE IVW 1.00 7.913125e-07 0.037768 DF
UKB-a:279 Leg fat mass (left) 974 Body mass index 7 Coronary heart disease 0.945427 Penalised mode 0.67 4.292818e-13 0.122758 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.366622 Simple median 0.80 5.570697e-08 0.067492 HF
UKB-a:286 Arm fat percentage (left) 2 Body mass index 7 Coronary heart disease 0.805668 Simple mode 0.70 5.840801e-13 0.104481 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.477221 Simple median 0.82 6.939404e-11 0.073171 HF
UKB-a:287 Arm fat mass (left) 95 Body mass index 7 Coronary heart disease 0.735344 Weighted mode 0.59 8.322863e-13 0.095595 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.367980 Simple median 0.83 9.784494e-12 0.054038 HF
UKB-a:286 Arm fat percentage (left) 835 Body mass index 7 Coronary heart disease 0.804429 Simple mode 0.71 1.138672e-12 0.105844 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.477221 Simple median 0.82 6.939404e-11 0.073171 HF
UKB-a:382 Waist circumference 974 Body mass index 7 Coronary heart disease 0.796354 Penalised mode 0.62 3.181022e-12 0.106395 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.368378 Simple median 0.86 3.054552e-08 0.066515 Tophits
UKB-a:248 Body mass index (BMI) 835 Body mass index 7 Coronary heart disease -0.694099 Weighted mode 0.66 4.991444e-12 0.095747 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.353634 Simple median 0.80 9.473961e-14 0.047480 HF
UKB-a:275 Leg fat mass (right) 974 Body mass index 7 Coronary heart disease 0.888052 Penalised mode 0.69 6.354069e-12 0.122341 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.360455 Simple median 0.82 5.916537e-08 0.066489 HF
UKB-a:291 Trunk fat mass 974 Body mass index 7 Coronary heart disease 0.291783 Simple median 0.63 1.116904e-11 0.042969 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.255400 FE IVW 0.82 6.364277e-16 0.031601 DF
1017 Immunoglobulin G index levels 95 Body mass index 7 Coronary heart disease -0.006094 FE IVW 1.00 4.863336e-11 0.000927 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF -0.017948 FE IVW 1.00 3.488601e-10 0.002860 DF
UKB-a:249 Weight 835 Body mass index 7 Coronary heart disease 0.654474 Simple mode 0.63 1.138001e-10 0.097365 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.258414 RE IVW 0.76 5.969626e-13 0.034186 HF
UKB-a:203 Illnesses of father: None of the above (group 2) 974 Body mass index 7 Coronary heart disease 0.444511 FE IVW 1.00 1.330967e-10 0.069200 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 1.092901 FE IVW 1.00 4.198756e-25 0.105598 DF
UKB-a:265 Whole body fat mass 974 Body mass index 7 Coronary heart disease 0.664224 Penalised mode 0.65 1.872351e-10 0.099444 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.312677 Simple median 0.88 2.582318e-08 0.056160 HF
UKB-a:286 Arm fat percentage (left) 95 Body mass index 7 Coronary heart disease 0.487486 Penalised median 0.65 2.122102e-10 0.076742 DF + HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.477221 Simple median 0.82 6.939404e-11 0.073171 HF
UKB-a:264 Body fat percentage 95 Body mass index 7 Coronary heart disease 0.438811 Penalised median 0.61 4.799865e-10 0.070486 DF + HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.379181 Simple median 0.78 3.589131e-07 0.074502 HF
UKB-a:264 Body fat percentage 835 Body mass index 7 Coronary heart disease 0.689867 Simple mode 0.67 1.603721e-09 0.109133 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.379181 Simple median 0.78 3.589131e-07 0.074502 HF
UKB-a:249 Weight 2 Body mass index 7 Coronary heart disease 0.660285 Simple mode 0.69 1.837915e-09 0.105890 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.258414 RE IVW 0.76 5.969626e-13 0.034186 HF
91 Obesity class 2 95 Body mass index 7 Coronary heart disease 0.279100 Simple mean 0.77 2.810549e-09 0.012222 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.104290 FE IVW 0.73 3.742677e-07 0.020523 HF
498 X-11327 2 Body mass index 7 Coronary heart disease -0.411327 FE IVW 1.00 3.704558e-09 0.069753 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF -0.445458 FE IVW 1.00 4.700355e-10 0.071516 DF
638 Asparagine 974 Body mass index 7 Coronary heart disease -0.309086 FE IVW 1.00 8.828809e-09 0.053737 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.418985 FE IVW 1.00 5.542329e-06 0.092224 DF
UKB-a:210 Illnesses of mother: Alzheimer's disease/dementia 2 Body mass index 7 Coronary heart disease -0.674114 FE IVW 1.00 1.239013e-08 0.118385 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 2.139980 FE IVW 1.00 3.447686e-15 0.271794 DF
UKB-a:210 Illnesses of mother: Alzheimer's disease/dementia 835 Body mass index 7 Coronary heart disease -0.678576 FE IVW 1.00 4.183052e-08 0.123761 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 2.139980 FE IVW 1.00 3.447686e-15 0.271794 DF
UKB-a:290 Trunk fat percentage 974 Body mass index 7 Coronary heart disease 0.281525 Simple median 0.59 5.220738e-08 0.051716 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.273991 RE IVW 0.76 7.129792e-11 0.039689 HF
902 Concentration of medium HDL particles 974 Body mass index 7 Coronary heart disease 0.046923 FE IVW 1.00 7.816738e-08 0.008736 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF -0.232728 FE IVW 1.00 7.855474e-06 0.052075 DF
902 Concentration of medium HDL particles 974 Body mass index 8 Coronary heart disease 0.046923 FE IVW 1.00 7.816738e-08 0.008736 DF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.256227 FE IVW 1.00 3.038478e-13 0.035135 DF
UKB-a:290 Trunk fat percentage 835 Body mass index 7 Coronary heart disease 0.575725 Simple mode 0.70 1.348976e-07 0.105022 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.273991 RE IVW 0.76 7.129792e-11 0.039689 HF
568 X-12040 974 Body mass index 8 Coronary heart disease -0.010655 FE IVW 1.00 1.737183e-07 0.002039 DF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.022148 FE IVW 1.00 1.663690e-27 0.002038 DF
UKB-a:274 Leg fat percentage (right) 2 Body mass index 7 Coronary heart disease 0.856586 Simple mode 0.67 1.753503e-07 0.158431 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.557208 Penalised median 0.82 3.371272e-09 0.094244 Tophits
UKB-a:264 Body fat percentage 2 Body mass index 7 Coronary heart disease 0.674663 Simple mode 0.68 2.075758e-07 0.125274 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.379181 Simple median 0.78 3.589131e-07 0.074502 HF
UKB-a:274 Leg fat percentage (right) 835 Body mass index 7 Coronary heart disease 0.874970 Simple mode 0.68 2.098564e-07 0.162913 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.557208 Penalised median 0.82 3.371272e-09 0.094244 Tophits
UKB-a:210 Illnesses of mother: Alzheimer's disease/dementia 974 Body mass index 7 Coronary heart disease -0.815706 FE IVW 1.00 2.997016e-07 0.159204 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 2.139980 FE IVW 1.00 3.447686e-15 0.271794 DF
UKB-a:290 Trunk fat percentage 2 Body mass index 7 Coronary heart disease 0.562214 Simple mode 0.69 6.082098e-07 0.108818 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.273991 RE IVW 0.76 7.129792e-11 0.039689 HF
UKB-a:278 Leg fat percentage (left) 95 Body mass index 7 Coronary heart disease 0.451195 Penalised median 0.64 7.918719e-07 0.091384 DF + HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.600633 Weighted median 0.85 6.895850e-10 0.097372 HF
51 Hip circumference 2 Body mass index 7 Coronary heart disease 0.816935 Simple mean 0.78 9.296272e-07 0.051262 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
63 Waist circumference 2 Body mass index 7 Coronary heart disease 0.816935 Simple mean 0.78 9.296272e-07 0.051262 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.501269 FE IVW 0.83 1.883179e-09 0.083440 HF
901 Total lipids in medium HDL 974 Body mass index 7 Coronary heart disease 0.043756 FE IVW 1.00 1.189295e-06 0.009008 DF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF -0.226681 FE IVW 1.00 2.455552e-07 0.043921 DF
901 Total lipids in medium HDL 974 Body mass index 8 Coronary heart disease 0.043756 FE IVW 1.00 1.189295e-06 0.009008 DF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.251695 FE IVW 1.00 1.392279e-17 0.029487 DF
UKB-a:282 Arm fat percentage (right) 95 Body mass index 7 Coronary heart disease 0.381502 Penalised median 0.64 2.154092e-06 0.080513 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.472462 Weighted median 0.84 5.307805e-10 0.076084 HF
65 Waist circumference 95 Body mass index 7 Coronary heart disease 0.714767 RE IVW 0.80 9.276447e-06 0.072333 DF + HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.519883 Penalised median 0.81 2.835560e-07 0.101262 HF
MATCH (cf:Gwas)-[r1:MR]-> (exposure:Gwas {trait: "Body mass index"}) -[r2:MR]->(outcome:Gwas {trait: "Coronary heart disease"}) <-[r3:MR]-(cf:Gwas) WHERE r1.p < 1e-05 AND r2.p < 1e-05 AND r3.p < 1e-05 AND cf.id <> exposure.id AND cf.id <> outcome.id AND exposure.id <> outcome.id AND cf.trait <> exposure.trait AND cf.trait <> outcome.trait AND exposure.trait <> outcome.trait RETURN exposure {.id, .trait}, outcome {.id, .trait}, cf {.id, .trait}, r1 {.estimate, .se, .p, .selection, .method, .moescore}, r2 {.estimate, .se, .p, .selection, .method, .moescore}, r3 {.estimate, .se, .p, .selection, .method, .moescore} ORDER BY r1.p;
curl -X 'GET' -H 'Accept: */*' -H 'Accept-Encoding: gzip, deflate' -H 'Connection: keep-alive' -H 'User-Agent: python-requests/2.22.0' 'http://api.epigraphdb.org_private/confounder?exposure=Body+mass+index&outcome=Coronary+heart+disease&type=confounder&pval_threshold=1e-05'