Confounder MR causal estimate

MR evidence on confounding traits between exposure and outcome

Exposure
Outcome

 

Confounder type:                         
P-value threshold: 1e-5
   

 

 

Summary

This module provides 4 different queries for traits causally related to an exposure-outcome pair using data from MR-EvE (Hemani et al, bioRxiv 10.1101/173682).

confounder
intermediate
reverse_intermediate
collider

 Data sources

  • MR-EvE (Hemani et al, Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome, bioRxiv 10.1101/173682)

 How to use

Enter an exposure and outcome pair of traits, then select whether you want to find potential confounders, colliders or intermediates (either forward or reverse). Finally, choose a p-value threshold for the strength of MR evidence to include, then click the Search button.

View the top results in the Network plot tab, access and search the full results in the Table tab, or use the Query tab to find out how to download data using the API.

Examples

 Displays 50 / 86 paths

 

cf.id cf.trait exposure.id exposure.trait outcome.id outcome.trait r1.estimate r1.method r1.moescore r1.p r1.se r1.selection r2.estimate r2.method r2.moescore r2.p r2.se r2.selection r3.estimate r3.method r3.moescore r3.p r3.se r3.selection
UKB-a:252 Long-standing illness disability or infirmity 2 Body mass index 8 Coronary heart disease 0.065335 FE IVW 0.95 2.756851e-41 0.004855 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.011449 FE IVW 0.79 2.895021e-06 0.002447 HF
UKB-a:252 Long-standing illness disability or infirmity 974 Body mass index 8 Coronary heart disease 0.069359 FE IVW 0.93 3.856388e-41 0.005163 DF + HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.011449 FE IVW 0.79 2.895021e-06 0.002447 HF
UKB-a:490 Medication for cholesterol blood pressure or diabetes: Blood pressure medication 2 Body mass index 7 Coronary heart disease 0.085358 FE IVW 0.92 1.400380e-31 0.007301 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.031965 FE IVW 0.80 2.175087e-21 0.003366 Tophits
UKB-a:490 Medication for cholesterol blood pressure or diabetes: Blood pressure medication 2 Body mass index 8 Coronary heart disease 0.085358 FE IVW 0.92 1.400380e-31 0.007301 Tophits 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.024505 Penalised median 0.81 8.398889e-06 0.005501 HF
UKB-a:24 Number of treatments/medications taken 2 Body mass index 7 Coronary heart disease 0.108110 FE IVW 0.92 7.207905e-28 0.009880 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.033137 RE IVW 0.79 5.018520e-06 0.005534 HF
UKB-a:24 Number of treatments/medications taken 2 Body mass index 8 Coronary heart disease 0.108110 FE IVW 0.92 7.207905e-28 0.009880 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.035320 Weighted median 0.78 2.126288e-06 0.007450 HF
UKB-a:22 Number of self-reported non-cancer illnesses 835 Body mass index 7 Coronary heart disease 0.104521 FE IVW 0.90 8.163615e-24 0.010388 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.028900 RE IVW 0.84 1.020055e-06 0.004555 HF
UKB-a:450 Medication for cholesterol blood pressure diabetes or take exogenous hormones: Blood pressure medication 2 Body mass index 7 Coronary heart disease 0.056120 FE IVW 0.89 2.312766e-21 0.005914 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.018134 FE IVW 0.80 2.147247e-11 0.002708 Tophits
UKB-a:450 Medication for cholesterol blood pressure diabetes or take exogenous hormones: Blood pressure medication 2 Body mass index 8 Coronary heart disease 0.056120 FE IVW 0.89 2.312766e-21 0.005914 Tophits 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.020173 FE IVW 0.84 3.325121e-18 0.002319 HF
UKB-a:490 Medication for cholesterol blood pressure or diabetes: Blood pressure medication 974 Body mass index 7 Coronary heart disease 0.080067 FE IVW 0.84 1.413128e-19 0.008846 DF + HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.031965 FE IVW 0.80 2.175087e-21 0.003366 Tophits
UKB-a:490 Medication for cholesterol blood pressure or diabetes: Blood pressure medication 974 Body mass index 8 Coronary heart disease 0.080067 FE IVW 0.84 1.413128e-19 0.008846 DF + HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.024505 Penalised median 0.81 8.398889e-06 0.005501 HF
UKB-a:488 Medication for cholesterol blood pressure or diabetes: Cholesterol lowering medication 2 Body mass index 7 Coronary heart disease 0.062939 FE IVW 0.91 6.107266e-19 0.007080 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.048103 Simple mean 0.81 5.903591e-10 0.004626 DF + HF
UKB-a:488 Medication for cholesterol blood pressure or diabetes: Cholesterol lowering medication 2 Body mass index 8 Coronary heart disease 0.062939 FE IVW 0.91 6.107266e-19 0.007080 Tophits 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.038915 Penalised median 0.73 2.979118e-09 0.006559 DF + HF
UKB-a:24 Number of treatments/medications taken 835 Body mass index 7 Coronary heart disease 0.096224 FE IVW 0.92 6.582638e-19 0.010834 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.033137 RE IVW 0.79 5.018520e-06 0.005534 HF
UKB-a:61 Non-cancer illness code self-reported: hypertension 2 Body mass index 8 Coronary heart disease 0.082804 Simple mean 0.93 4.501768e-18 0.006634 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.017438 Penalised median 0.76 4.522159e-06 0.003803 HF
UKB-a:150 Treatment/medication code: amlodipine 2 Body mass index 8 Coronary heart disease 0.017493 FE IVW 0.89 5.317829e-18 0.002023 HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.004129 FE IVW 0.79 1.312808e-08 0.000726 HF
UKB-a:22 Number of self-reported non-cancer illnesses 2 Body mass index 7 Coronary heart disease 0.102070 RE IVW 0.93 7.260774e-18 0.008432 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.028900 RE IVW 0.84 1.020055e-06 0.004555 HF
UKB-a:490 Medication for cholesterol blood pressure or diabetes: Blood pressure medication 95 Body mass index 7 Coronary heart disease 0.101288 FE IVW 0.81 1.409070e-17 0.011868 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.031965 FE IVW 0.80 2.175087e-21 0.003366 Tophits
UKB-a:121 Treatment/medication code: simvastatin 2 Body mass index 8 Coronary heart disease 0.031216 FE IVW 0.91 1.456319e-16 0.003779 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.019663 Weighted median 0.76 9.407554e-09 0.003425 DF + HF
UKB-a:490 Medication for cholesterol blood pressure or diabetes: Blood pressure medication 835 Body mass index 7 Coronary heart disease 0.092458 RE IVW 0.95 1.471313e-15 0.008269 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.031965 FE IVW 0.80 2.175087e-21 0.003366 Tophits
UKB-a:488 Medication for cholesterol blood pressure or diabetes: Cholesterol lowering medication 974 Body mass index 7 Coronary heart disease 0.061469 FE IVW 0.90 3.781013e-15 0.007819 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.048103 Simple mean 0.81 5.903591e-10 0.004626 DF + HF
UKB-a:488 Medication for cholesterol blood pressure or diabetes: Cholesterol lowering medication 974 Body mass index 8 Coronary heart disease 0.061469 FE IVW 0.90 3.781013e-15 0.007819 Tophits 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.038915 Penalised median 0.73 2.979118e-09 0.006559 DF + HF
UKB-a:117 Treatment/medication code: ramipril 2 Body mass index 7 Coronary heart disease 0.018629 FE IVW 0.84 6.311165e-15 0.002389 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.012350 FE IVW 0.88 1.605491e-25 0.001183 Tophits
798 Myocardial infarction 835 Body mass index 7 Coronary heart disease 0.367509 FE IVW 0.89 8.501511e-15 0.047360 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.918621 Simple median 0.94 2.002929e-76 0.049651 HF
UKB-a:121 Treatment/medication code: simvastatin 974 Body mass index 8 Coronary heart disease 0.030356 FE IVW 0.83 9.732121e-15 0.003921 DF + HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.019663 Weighted median 0.76 9.407554e-09 0.003425 DF + HF
UKB-a:488 Medication for cholesterol blood pressure or diabetes: Cholesterol lowering medication 835 Body mass index 7 Coronary heart disease 0.066628 FE IVW 0.93 2.254798e-14 0.008726 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.048103 Simple mean 0.81 5.903591e-10 0.004626 DF + HF
UKB-a:450 Medication for cholesterol blood pressure diabetes or take exogenous hormones: Blood pressure medication 835 Body mass index 7 Coronary heart disease 0.055416 FE IVW 0.86 2.539695e-14 0.007273 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.018134 FE IVW 0.80 2.147247e-11 0.002708 Tophits
UKB-a:22 Number of self-reported non-cancer illnesses 95 Body mass index 7 Coronary heart disease 0.107776 FE IVW 0.83 1.120212e-13 0.014513 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.028900 RE IVW 0.84 1.020055e-06 0.004555 HF
UKB-a:488 Medication for cholesterol blood pressure or diabetes: Cholesterol lowering medication 95 Body mass index 7 Coronary heart disease 0.083439 FE IVW 0.71 2.590304e-13 0.011408 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.048103 Simple mean 0.81 5.903591e-10 0.004626 DF + HF
798 Myocardial infarction 2 Body mass index 7 Coronary heart disease 0.396230 Simple mean 0.92 2.842824e-12 0.047086 HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.918621 Simple median 0.94 2.002929e-76 0.049651 HF
798 Myocardial infarction 2 Body mass index 8 Coronary heart disease 0.396230 Simple mean 0.92 2.842824e-12 0.047086 HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.566490 FE IVW 0.78 1.368330e-48 0.038671 Tophits
UKB-a:450 Medication for cholesterol blood pressure diabetes or take exogenous hormones: Blood pressure medication 974 Body mass index 7 Coronary heart disease 0.050708 FE IVW 0.86 1.687891e-11 0.007534 DF + HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.018134 FE IVW 0.80 2.147247e-11 0.002708 Tophits
UKB-a:450 Medication for cholesterol blood pressure diabetes or take exogenous hormones: Blood pressure medication 974 Body mass index 8 Coronary heart disease 0.050708 FE IVW 0.86 1.687891e-11 0.007534 DF + HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.020173 FE IVW 0.84 3.325121e-18 0.002319 HF
UKB-a:132 Treatment/medication code: aspirin 2 Body mass index 7 Coronary heart disease 0.025493 FE IVW 0.92 2.548112e-11 0.003822 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.032591 FE IVW 0.90 3.259363e-57 0.002044 DF + HF
UKB-a:132 Treatment/medication code: aspirin 2 Body mass index 8 Coronary heart disease 0.025493 FE IVW 0.92 2.548112e-11 0.003822 Tophits 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.023385 Simple median 0.81 8.296835e-12 0.003422 Tophits
UKB-a:61 Non-cancer illness code self-reported: hypertension 974 Body mass index 8 Coronary heart disease 0.069963 RE IVW 0.92 2.904512e-11 0.006227 HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.017438 Penalised median 0.76 4.522159e-06 0.003803 HF
UKB-a:117 Treatment/medication code: ramipril 835 Body mass index 7 Coronary heart disease 0.016623 FE IVW 0.79 2.805859e-10 0.002635 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.012350 FE IVW 0.88 1.605491e-25 0.001183 Tophits
UKB-a:63 Non-cancer illness code self-reported: heart attack/myocardial infarction 2 Body mass index 7 Coronary heart disease 0.010375 FE IVW 0.92 4.425449e-10 0.001663 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.020656 Weighted median 0.93 4.525622e-41 0.001539 HF
UKB-a:63 Non-cancer illness code self-reported: heart attack/myocardial infarction 2 Body mass index 8 Coronary heart disease 0.010375 FE IVW 0.92 4.425449e-10 0.001663 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.016806 Weighted median 0.83 7.996198e-23 0.001709 HF
UKB-a:452 Medication for pain relief constipation heartburn: Aspirin 2 Body mass index 7 Coronary heart disease 0.029719 RE IVW 0.95 5.942029e-10 0.004092 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.035065 Simple median 0.90 6.135298e-21 0.003735 Tophits
UKB-a:452 Medication for pain relief constipation heartburn: Aspirin 2 Body mass index 8 Coronary heart disease 0.029719 RE IVW 0.95 5.942029e-10 0.004092 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.027442 Penalised median 0.78 3.511473e-15 0.003486 HF
798 Myocardial infarction 974 Body mass index 7 Coronary heart disease 0.404068 RE IVW 0.94 6.427648e-10 0.046554 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.918621 Simple median 0.94 2.002929e-76 0.049651 HF
798 Myocardial infarction 974 Body mass index 8 Coronary heart disease 0.404068 RE IVW 0.94 6.427648e-10 0.046554 HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.566490 FE IVW 0.78 1.368330e-48 0.038671 Tophits
UKB-a:434 Vascular/heart problems diagnosed by doctor: Heart attack 2 Body mass index 7 Coronary heart disease 0.010265 FE IVW 0.88 1.002469e-09 0.001680 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.019510 FE IVW 0.94 4.096223e-88 0.000980 DF
UKB-a:434 Vascular/heart problems diagnosed by doctor: Heart attack 2 Body mass index 8 Coronary heart disease 0.010265 FE IVW 0.88 1.002469e-09 0.001680 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.016203 Simple mean 0.80 2.130016e-07 0.001162 HF
UKB-a:452 Medication for pain relief constipation heartburn: Aspirin 835 Body mass index 7 Coronary heart disease 0.027204 FE IVW 0.89 1.175629e-09 0.004472 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.035065 Simple median 0.90 6.135298e-21 0.003735 Tophits
UKB-a:22 Number of self-reported non-cancer illnesses 974 Body mass index 7 Coronary heart disease 0.088849 RE IVW 0.87 3.005147e-09 0.010970 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.028900 RE IVW 0.84 1.020055e-06 0.004555 HF
UKB-a:176 Treatment/medication code: atorvastatin 2 Body mass index 7 Coronary heart disease 0.012793 RE IVW 0.86 3.897541e-09 0.001890 HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.010146 Simple median 0.84 8.552671e-09 0.001762 Tophits
UKB-a:176 Treatment/medication code: atorvastatin 2 Body mass index 8 Coronary heart disease 0.012793 RE IVW 0.86 3.897541e-09 0.001890 HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.008398 Penalised median 0.78 2.532315e-07 0.001629 DF
UKB-a:62 Non-cancer illness code self-reported: angina 835 Body mass index 7 Coronary heart disease 0.012386 FE IVW 0.88 4.880228e-09 0.002117 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.023720 Simple mean 0.90 2.939289e-17 0.001237 HF
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina 2 Body mass index 7 Coronary heart disease 0.012350 FE IVW 0.84 7.923303e-09 0.002140 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.022846 Simple median 0.91 5.484727e-32 0.001941 HF
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina 2 Body mass index 8 Coronary heart disease 0.012350 FE IVW 0.84 7.923303e-09 0.002140 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.020558 Weighted median 0.85 1.587157e-26 0.001929 HF
UKB-a:116 Treatment/medication code: lisinopril 2 Body mass index 8 Coronary heart disease 0.010627 FE IVW 0.74 1.118145e-08 0.001861 Tophits 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.004160 FE IVW 0.79 6.371347e-06 0.000922 HF
UKB-a:436 Vascular/heart problems diagnosed by doctor: Angina 835 Body mass index 7 Coronary heart disease 0.013678 RE IVW 0.86 2.512443e-08 0.002134 HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.022846 Simple median 0.91 5.484727e-32 0.001941 HF
UKB-a:217 Illnesses of siblings: Heart disease 95 Body mass index 7 Coronary heart disease 0.024593 FE IVW 0.81 2.747429e-08 0.004426 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.032342 FE IVW 0.93 2.081430e-69 0.001837 Tophits
UKB-a:162 Treatment/medication code: perindopril 2 Body mass index 7 Coronary heart disease 0.007327 FE IVW 0.76 4.796732e-08 0.001342 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.003820 FE IVW 0.85 3.971312e-10 0.000611 Tophits
UKB-a:162 Treatment/medication code: perindopril 2 Body mass index 8 Coronary heart disease 0.007327 FE IVW 0.76 4.796732e-08 0.001342 Tophits 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.004219 FE IVW 0.76 4.336822e-10 0.000676 HF
UKB-a:117 Treatment/medication code: ramipril 974 Body mass index 7 Coronary heart disease 0.018016 RE IVW 0.78 6.976321e-08 0.002631 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.012350 FE IVW 0.88 1.605491e-25 0.001183 Tophits
UKB-a:150 Treatment/medication code: amlodipine 974 Body mass index 8 Coronary heart disease 0.016311 Simple mean 0.85 7.155432e-08 0.002326 HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.004129 FE IVW 0.79 1.312808e-08 0.000726 HF
UKB-a:63 Non-cancer illness code self-reported: heart attack/myocardial infarction 835 Body mass index 7 Coronary heart disease 0.009979 FE IVW 0.79 8.153030e-08 0.001860 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.020656 Weighted median 0.93 4.525622e-41 0.001539 HF
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease 2 Body mass index 7 Coronary heart disease 0.009694 FE IVW 0.90 1.231921e-07 0.001833 DF + HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.023897 FE IVW 0.92 2.062500e-114 0.001051 DF
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease 2 Body mass index 8 Coronary heart disease 0.009694 FE IVW 0.90 1.231921e-07 0.001833 DF + HF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.022996 Weighted median 0.75 4.386245e-30 0.002018 HF
UKB-a:24 Number of treatments/medications taken 974 Body mass index 7 Coronary heart disease 0.091411 Simple median 0.89 1.277665e-07 0.017306 Tophits 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.033137 RE IVW 0.79 5.018520e-06 0.005534 HF
UKB-a:24 Number of treatments/medications taken 974 Body mass index 8 Coronary heart disease 0.091411 Simple median 0.89 1.277665e-07 0.017306 Tophits 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.035320 Weighted median 0.78 2.126288e-06 0.007450 HF
798 Myocardial infarction 95 Body mass index 7 Coronary heart disease 0.358480 FE IVW 0.77 1.321243e-07 0.067947 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.918621 Simple median 0.94 2.002929e-76 0.049651 HF
UKB-a:131 Treatment/medication code: atenolol 2 Body mass index 7 Coronary heart disease 0.011494 FE IVW 0.79 1.543231e-07 0.002190 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.011286 FE IVW 0.91 1.233686e-28 0.001017 Tophits
UKB-a:131 Treatment/medication code: atenolol 2 Body mass index 8 Coronary heart disease 0.011494 FE IVW 0.79 1.543231e-07 0.002190 DF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.009050 Penalised median 0.91 1.939953e-08 0.001611 HF
UKB-a:217 Illnesses of siblings: Heart disease 2 Body mass index 7 Coronary heart disease 0.019789 FE IVW 0.77 1.616401e-07 0.003777 Tophits 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.032342 FE IVW 0.93 2.081430e-69 0.001837 Tophits
UKB-a:217 Illnesses of siblings: Heart disease 2 Body mass index 8 Coronary heart disease 0.019789 FE IVW 0.77 1.616401e-07 0.003777 Tophits 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.022277 Weighted median 0.82 1.244922e-11 0.003288 HF
UKB-a:116 Treatment/medication code: lisinopril 974 Body mass index 8 Coronary heart disease 0.011050 FE IVW 0.77 1.876066e-07 0.002120 DF + HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.004160 FE IVW 0.79 6.371347e-06 0.000922 HF
UKB-a:62 Non-cancer illness code self-reported: angina 2 Body mass index 7 Coronary heart disease 0.009916 FE IVW 0.83 4.686446e-07 0.001968 DF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF 0.023720 Simple mean 0.90 2.939289e-17 0.001237 HF
UKB-a:62 Non-cancer illness code self-reported: angina 2 Body mass index 8 Coronary heart disease 0.009916 FE IVW 0.83 4.686446e-07 0.001968 DF 0.330890 FE IVW 0.75 1.308513e-06 0.068387 DF 0.019498 Weighted median 0.86 4.763438e-26 0.001847 HF
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease 835 Body mass index 7 Coronary heart disease 0.011088 RE IVW 0.87 1.234827e-06 0.002060 DF + HF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.023897 FE IVW 0.92 2.062500e-114 0.001051 DF
UKB-a:489 Medication for cholesterol blood pressure or diabetes: None of the above 974 Body mass index 8 Coronary heart disease -0.122780 Penalised mode 0.82 1.357784e-06 0.020267 DF + HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF -0.034562 Penalised median 0.64 3.106667e-06 0.007411 HF
UKB-a:132 Treatment/medication code: aspirin 974 Body mass index 7 Coronary heart disease 0.024939 RE IVW 0.77 1.766364e-06 0.004276 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.032591 FE IVW 0.90 3.259363e-57 0.002044 DF + HF
UKB-a:132 Treatment/medication code: aspirin 974 Body mass index 8 Coronary heart disease 0.024939 RE IVW 0.77 1.766364e-06 0.004276 HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.023385 Simple median 0.81 8.296835e-12 0.003422 Tophits
UKB-a:217 Illnesses of siblings: Heart disease 835 Body mass index 7 Coronary heart disease 0.019673 FE IVW 0.81 2.386687e-06 0.004170 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.032342 FE IVW 0.93 2.081430e-69 0.001837 Tophits
UKB-a:218 Illnesses of siblings: None of the above (group 1) 2 Body mass index 7 Coronary heart disease -0.068043 FE Egger 0.74 2.653487e-06 0.014490 HF 0.397101 Simple median 0.92 4.793827e-08 0.072745 HF -0.026347 FE IVW 0.74 2.143732e-21 0.002774 Tophits
UKB-a:117 Treatment/medication code: ramipril 95 Body mass index 7 Coronary heart disease 0.021054 Simple median 0.77 2.816226e-06 0.004495 HF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.012350 FE IVW 0.88 1.605491e-25 0.001183 Tophits
UKB-a:132 Treatment/medication code: aspirin 835 Body mass index 7 Coronary heart disease 0.031564 Simple median 0.85 3.462775e-06 0.006801 Tophits 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.032591 FE IVW 0.90 3.259363e-57 0.002044 DF + HF
UKB-a:452 Medication for pain relief constipation heartburn: Aspirin 974 Body mass index 7 Coronary heart disease 0.025649 RE IVW 0.76 4.314422e-06 0.004643 HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.035065 Simple median 0.90 6.135298e-21 0.003735 Tophits
UKB-a:452 Medication for pain relief constipation heartburn: Aspirin 974 Body mass index 8 Coronary heart disease 0.025649 RE IVW 0.76 4.314422e-06 0.004643 HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.027442 Penalised median 0.78 3.511473e-15 0.003486 HF
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease 974 Body mass index 7 Coronary heart disease 0.008423 FE IVW 0.85 7.299192e-06 0.001878 DF + HF 0.388520 FE IVW 0.89 3.417302e-15 0.049338 DF 0.023897 FE IVW 0.92 2.062500e-114 0.001051 DF
UKB-a:534 Diagnoses - main ICD10: I25 Chronic ischaemic heart disease 974 Body mass index 8 Coronary heart disease 0.008423 FE IVW 0.85 7.299192e-06 0.001878 DF + HF 0.328476 FE IVW 0.85 6.966327e-06 0.073081 DF 0.022996 Weighted median 0.75 4.386245e-30 0.002018 HF
UKB-a:132 Treatment/medication code: aspirin 95 Body mass index 7 Coronary heart disease 0.037289 Penalised median 0.77 8.162286e-06 0.008359 DF 0.454937 Penalised median 0.78 1.017140e-06 0.093067 DF 0.032591 FE IVW 0.90 3.259363e-57 0.002044 DF + HF
UKB-a:131 Treatment/medication code: atenolol 835 Body mass index 7 Coronary heart disease 0.010746 FE IVW 0.82 8.753071e-06 0.002417 DF 0.359686 Simple median 0.91 1.938765e-06 0.075569 Tophits 0.011286 FE IVW 0.91 1.233686e-28 0.001017 Tophits
MATCH (cf:Gwas)<-[r1:MR]- (exposure:Gwas {trait: "Body mass index"}) -[r2:MR]->(outcome:Gwas {trait: "Coronary heart disease"}) -[r3:MR]->(cf:Gwas) WHERE r1.p < 1e-05 AND r2.p < 1e-05 AND r3.p < 1e-05 AND cf.id <> exposure.id AND cf.id <> outcome.id AND exposure.id <> outcome.id AND cf.trait <> exposure.trait AND cf.trait <> outcome.trait AND exposure.trait <> outcome.trait RETURN exposure {.id, .trait}, outcome {.id, .trait}, cf {.id, .trait}, r1 {.estimate, .se, .p, .selection, .method, .moescore}, r2 {.estimate, .se, .p, .selection, .method, .moescore}, r3 {.estimate, .se, .p, .selection, .method, .moescore} ORDER BY r1.p;
curl -X 'GET' -H 'Accept: */*' -H 'Accept-Encoding: gzip, deflate' -H 'Connection: keep-alive' -H 'User-Agent: python-requests/2.22.0' 'http://api.epigraphdb.org_private/confounder?exposure=Body+mass+index&outcome=Coronary+heart+disease&type=collider&pval_threshold=1e-05'